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Biogenic synthesis of metal nanoparticles from actinomycetes: biomedical applications and cytotoxicity

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Abstract

Biogenic synthesis of metal nanoparticles has been well proved by using bacteria, fungi, algae, actinomycetes, plants, etc. Among the different microorganisms used for the synthesis of metal nanoparticles, actinomycetes are less known. Although, there are reports, which have shown that actinomycetes are efficient candidates for the production of metal nanoparticles both intracellularly and extracellularly. The nanoparticles synthesized by the members of actinomycetes present good polydispersity and stability and possess significant biocidal activities against various pathogens. The present review focuses on biological synthesis of metal nanoparticles and their application in medicine. In addition, the toxicity of these biogenic metal nanoparticles to human beings and environment has also been discussed.

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Acknowledgments

Support from The National Science Centre (NCN)—“Grant Symphony 1” No. 2013/08/W/NZ8/00701 and from the project of “Enhancing Educational Potential of Nicolaus Copernicus University in the Disciplines of Mathematical and Natural Sciences—visiting professors” conducted under Sub-measure 4.1.1 Human Capital Operational Programme—Task 7 (Project No. POKL.04.01.01-00-081/10) are acknowledged.

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Authors and Affiliations

  1. Department of Microbiology, Nicolaus Copernicus University, 87-100, Torun, Poland

    Patrycja Golinska, Magdalena Wypij & Hanna Dahm

  2. Nanobiotechnology Laboratory, Department of Biotechnology, SGB Amravati University, Amravati, 444602, Maharashtra, India

    Avinash P. Ingle, Indarchand Gupta & Mahendra Rai

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  1. Patrycja Golinska
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  2. Magdalena Wypij
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  3. Avinash P. Ingle
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Correspondence to Mahendra Rai.

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Golinska, P., Wypij, M., Ingle, A.P. et al. Biogenic synthesis of metal nanoparticles from actinomycetes: biomedical applications and cytotoxicity. Appl Microbiol Biotechnol 98, 8083–8097 (2014). https://doi.org/10.1007/s00253-014-5953-7

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  • DOI: https://doi.org/10.1007/s00253-014-5953-7

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