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Salivary duct carcinomas: clinical and CT and MR imaging features in 20 patients

  • Head and Neck Radiology
  • Published:
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Abstract

Introduction

Salivary duct carcinoma (SDC) is an uncommon high grade adenocarcinoma of the salivary gland with a grave prognosis. The aim of this study was to investigate the clinical and CT and MR imaging features of SDC.

Methods

We retrospectively evaluated the clinical and CT and MR imaging findings in 20 patients (14 men and six women; mean age, 59 years) with histologically proved SDC. We also tried to correlate clinicoradiological tumor staging with pathologic tumor staging in 17 patients who underwent surgery.

Results

The tumor originated in the parotid gland (n = 11; 55%), the submandibular gland (n = 7; 35%) and the buccal space along the distal Stensen's duct (n = 2; 10%). Locoregional recurrence occurred in 41% and distant metastasis in 47%. Fifty-eight percent died of the disease with a mean survival period of 32 months after diagnosis. On CT and MR images, SDC was mostly seen as an ill-defined (85%) and infiltrative (60%) mass with frequent calcification (50%) and necrosis (80%). Although various signal intensities were seen on MR images, six of nine tumors contained the areas of marked hypointensity on T2-weighted images. Clinicoradiological tumor staging correlated well with pathologic tumor staging in 82% of the patients.

Conclusion

Ill-defined, infiltrative mass with calcification on CT scans and the areas of marked hypointensity on T2-weighted MR images may be useful radiologic features to suggest the diagnosis of SDC. CT and MR imaging are useful for staging of SDC.

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References

  1. Colmenero Ruiz C, Patrón Romero M, Martín Pérez M (1993) Salivary duct carcinoma: a report of nine cases. J Oral Maxillofac Surg 51:641–646

    Article  PubMed  CAS  Google Scholar 

  2. Brandwein MS, Jagirdar J, Patil J, Biller H, Kaneko M (1990) Salivary gland carcinoma (cribriform salivary gland carcinoma of excretory ducts). A clinicopathologic and immunohistochemical study of 12 cases. Cancer 65:2307–2314

    Article  PubMed  CAS  Google Scholar 

  3. Luna MA, Batsakis JG, Ordóñez NG, Mackay B, Tortoledo ME (1987) Salivary gland adenocarcinomas: a clinicopathologic analysis of three distinct types. Semin Diagn Pathol 4:117–135

    PubMed  CAS  Google Scholar 

  4. Kleinsasser O, Klein HJ, Hübner G (1968) Salivary duct carcinoma: a group of salivary gland tumours analogous to mammary duct carcinoma. Arch Klin Exp Ohren Nasen Kehlkopfheilkd 192:100–105

    Article  PubMed  CAS  Google Scholar 

  5. Garland TA, Innes DJ, Fechner RE (1984) Salivary duct carcinoma: and analysis of four cases with review of literature. Am J Clin Pathol 81:436–441

    PubMed  CAS  Google Scholar 

  6. Chen KT, Hafez GR (1981) Infiltrating salivary duct carcinoma. Arch Otolaryngol 107:37–39

    Article  PubMed  CAS  Google Scholar 

  7. Barnes L, Rao U, Krause J, Contis L, Schwartz A, Scalamogna P (1994) Salivary duct carcinoma. Part I: a clinicopathologic evaluation and DNA image analysis of 13 cases with review of the literature. Oral Surg Oral Med Oral Pathol 78:64–73

    Article  PubMed  CAS  Google Scholar 

  8. Huh KH, Heo MS, Lee SS, Choi SC (2003) Three new cases of salivary duct carcinoma in the palate: a radiologic investigation and review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 95:752–760

    Article  PubMed  Google Scholar 

  9. Hosal AS, Fan C, Barnes L, Myers EN (2003) Salivary duct carcinoma. Otolaryngol Head Neck Surg 129:720–725

    Article  PubMed  Google Scholar 

  10. Motoori K, Iida Y, Nagai Y, Yamamoto S, Ueda T, Funatsu H, Ito H, Yoshitaka O (2005) MR imaging of salivary duct carcinoma. AJNR Am J Neuroradiol 26:1201–1206

    PubMed  Google Scholar 

  11. Kashiwagi N, Takashima S, Tomita Y, Araki Y, Yoshino K, Taniguchi S, Nakanishi K (2009) Salivary duct carcinoma of the parotid gland: clinical and MR features in six patients. Br J Radiol 82:800–804

    Article  PubMed  CAS  Google Scholar 

  12. Okada F, Honda K, Ando Y, Nakayama T, Sai M, Tanoue S, Matsumoto S, Mori H (2009) Salivary duct carcinoma of the extra-glandular segment of Stensen's duct: radiological findings and pathological correlation. Eur Radiol 19:254–257

    Article  PubMed  Google Scholar 

  13. Greene FL, Page DL, Fleming ID et al (2010) American Joint Committee on Caner Staging Manual, 7th edn. Springer-Verlag, New York

    Google Scholar 

  14. Delgado R, Klimstra D, Albores-Saavedra J (1996) Low grade salivary duct carcinoma. A distinctive variant with a low grade histology and a predominant intraductal growth pattern. Cancer 78:958–967

    Article  PubMed  CAS  Google Scholar 

  15. van Heerden WF, Raubenheimer EJ, Swart TJ, Boy SC (2003) Intraoral salivary duct carcinoma: a report of 5 cases. J Oral Maxillofac Surg 61:126–131

    Article  PubMed  Google Scholar 

  16. Lewis JE, McKinney BC, Weiland LH, Ferreiro JA, Olsen KD (1996) Salivary duct carcinoma. Clinicopathologic and immunohistochemical review of 26 cases. Cancer 77:223–230

    Article  PubMed  CAS  Google Scholar 

  17. Guzzo M, Di Palma S, Grandi C, Molinari R (1997) Salivary duct carcinoma clinical characteristics and treatment strategies. Head Neck 19:126–133

    Article  PubMed  CAS  Google Scholar 

  18. Grenko RT, Gemryd P, Tytor M, Lundqvist PG, Boeryd B (1995) Salivary duct carcinoma. Histopathology 26:261–266

    Article  PubMed  CAS  Google Scholar 

  19. Afzelius LE, Cameron WR, Svensson C (1987) Salivary duct carcinoma—a clinicopathologic study of 12 cases. Head Neck Surg 9:151–156

    Article  PubMed  CAS  Google Scholar 

  20. Delgado R, Vuitch F, Albores-Saavedra J (1993) Salivary duct carcinoma. Cancer 72:1503–1512

    Article  PubMed  CAS  Google Scholar 

  21. Hui KK, Batsakis JG, Luna MA, Mackay B, Byers RM (1986) Salivary duct adenocarcinoma: a high-grade malignancy. J Laryngol Otol 100:105–111

    Article  PubMed  CAS  Google Scholar 

  22. Som PM, Biller HF (1989) High-grade malignancies of the parotid gland: identification with MR imaging. Radiology 173:823–826

    PubMed  CAS  Google Scholar 

  23. Freling NJ, Molenaar WM, Vermey A, Mooyaart EL, Panders AK, Annyas AA, Thijn CJ (1992) Malignant parotid tumours: clinical use of MR imaging and histologic correlation. Radiology 185:691–696

    PubMed  CAS  Google Scholar 

  24. Joe VQ, Westesson PL (1994) Tumours of the parotid gland: MR imaging characteristics of various histologic types. AJR Am J Roentgenol 163:433–438

    PubMed  CAS  Google Scholar 

  25. Swartz JD, Rothman MI, Marlowe FI, Berger AS (1989) MR imaging of parotid mass lesions: attempts at histologic differentiation. J Comput Assist Tomogr 13:789–796

    Article  PubMed  CAS  Google Scholar 

  26. Okahara M, Kiyosue H, Hori Y, Matsumoto A, Mori H, Yokoyama S (2003) Parotid tumours: MR imaging with pathological correlation. Eur Radiol 13(Suppl 4):L25–L33

    Article  PubMed  Google Scholar 

  27. Sigal R, Monnet O, de Baere T, Micheau C, Shapeero LG, Julieron M, Bosq J, Vanel D, Piekarski JD, Luboinski B et al (1992) Adenoid cystic carcinoma of the head and neck: evaluation with MR imaging and clinical-pathologic correlation in 27 patients. Radiology 184:95–101

    PubMed  CAS  Google Scholar 

  28. Yousem DM, Kraut MA, Chalian AA (2000) Major salivary gland imaging. Radiology 216:19–29

    PubMed  CAS  Google Scholar 

  29. Yabuuchi H, Fukuya T, Tajima T, Hachitanda Y, Tomita K, Koga M (2003) Salivary gland tumours: diagnostic value of gadolinium-enhanced dynamic MR imaging with histologic correlation. Radiology 226:345–354

    Article  PubMed  Google Scholar 

  30. Eida S, Sumi M, Sakihama N, Takahashi H, Nakamura T (2007) Apparent diffusion coefficient mapping of salivary gland tumours: prediction of the benignancy and malignancy. AJNR Am J Neuroradiol 28:116–121

    PubMed  CAS  Google Scholar 

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Conflict of interest

We declare that we have no conflict of interest.

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Authors and Affiliations

  1. Department of Radiology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea

    Young Cheol Weon

  2. Department of Radiology, Boramae Medical Center, Seoul National University College of Medicine, Seoul, South Korea

    Sun-Won Park

  3. Department of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-dong, Gangnam-gu, Seoul, 135-710, South Korea

    Hyung-Jin Kim & Sung Tae Kim

  4. Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea

    Han-Sin Jeong, Chung Hwan Baek & Young-Ik Son

  5. Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea

    Young-Hyeh Ko

  6. Department of Pathology, Inha University College of Medicine, Incheon, South Korea

    In Suh Park

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  1. Young Cheol Weon
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  2. Sun-Won Park
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  3. Hyung-Jin Kim
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  5. Young-Hyeh Ko
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  7. Sung Tae Kim
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Corresponding author

Correspondence to Hyung-Jin Kim.

Additional information

Young Cheol Weon and Sun-Won Park contributed equally to this work

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Weon, Y.C., Park, SW., Kim, HJ. et al. Salivary duct carcinomas: clinical and CT and MR imaging features in 20 patients. Neuroradiology 54, 631–640 (2012). https://doi.org/10.1007/s00234-012-1014-z

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  • DOI: https://doi.org/10.1007/s00234-012-1014-z

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