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The Relationship Between COLI A1 Polymorphisms (Sp 1) and COLI A2 Polymorphisms (Eco R1 and Puv II) with Bone Mineral Density in Chinese Men and Women

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Abstract

Polymerase chain reaction was used to amplify across variable restriction sites of the COLI A1 and COLI A2 genes that encode the alpha 1 and 2 subunits of type I collagen. The relationship between these polymorphisms and bone mineral density (BMD) was studied in 683 Chinese men and women. In 100 men and women, COLI A1 Sp1 polymorphism was not found, which was consistent with other previous studies in Asian populations. However a statistically significant relationship was observed between COLI A2 Eco R1 and Puv II genotypes among the Chinese men studied. The mean BMD was consistently lower in men of the EE and PP genotype (P < 0.05 by analysis of variance [ANOVA]) than in men of the ee and pp genotypes. However, no association between BMD and the Eco R1 or Puv II genotypes was observed in Chinese women (P > 0.05 by ANOVA). We conclude that the COLI Al Sp1 binding site is absent in Hong Kong Chinese, whereas the COLI A2 Eco R1 and Puv II genetic polymorphisms may be associated with the BMD of elderly Chinese men.

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Acknowledgments

We are very grateful to Professor Stuart H. Ralston from the Department of Medicine and Therapeutics, University of Aberbeen, UK, for validating our COLI A1 studies.

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Authors and Affiliations

  1. Department of Family and Community Medicine, Chinese University of Hong Kong, 4/F, School of Public Health, Prince of Wales Hospital, Shatin, Hong Kong

    E. M. C. Lau & A. Sham

  2. Jockey Club Centre for Osteoporosis Care and Control, Chinese University of Hong Kong, Shatin, Hong Kong

    D. T. K. Choy

  3. Department of Medicine and Therapeutics, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong

    M. Li, J. Woo & T. Chung

Authors
  1. E. M. C. Lau
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  2. D. T. K. Choy
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  3. M. Li
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  4. J. Woo
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  5. T. Chung
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  6. A. Sham
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Correspondence to E. M. C. Lau.

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Lau, E.M.C., Choy, D.T.K., Li, M. et al. The Relationship Between COLI A1 Polymorphisms (Sp 1) and COLI A2 Polymorphisms (Eco R1 and Puv II) with Bone Mineral Density in Chinese Men and Women. Calcif Tissue Int 75, 133–137 (2004). https://doi.org/10.1007/s00223-003-0008-6

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