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Time course of changes in corticospinal excitability induced by motor imagery during action observation combined with peripheral nerve electrical stimulation

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Abstract

While previous studies assessed corticospinal excitability changes during and after motor imagery (MI) or action observation (AO) combined with peripheral nerve electrical stimulation (ES), we examined, for the first time, the time course of corticospinal excitability changes for MI during AO combined with ES (AO–MI + ES) using transcranial magnetic stimulation to measure motor evoked potentials (MEPs) in healthy individuals. Fourteen healthy volunteers participated in the following three sessions on different days: AO–MI alone, ES alone, and AO–MI + ES. In the AO–MI task, participants imagined squeezing and relaxing a ball, along with the respective actions shown in a movie, while passively holding the ball. We applied ES (intensity, 90% of the motor threshold) to the ulnar nerve at the wrist, which innervates the first dorsal interosseous (FDI) muscle. We assessed the FDI muscle MEPs at baseline and after every 5 min of the task for a total of 20 min. Additionally, participants completed the Vividness of Movement Imagery Questionnaire-2 (VMIQ-2) at the beginning of the experiment. Compared to baseline, AO–MI + ES significantly increased corticospinal excitability after 10 min, while AO–MI or ES alone had no effect on corticospinal excitability after 20 min. Moreover, the AO–MI + ES-induced cortical excitability changes were correlated with the VMIQ-2 scores for visual and kinaesthetic imagery. Collectively, our findings indicate that AO–MI + ES induces cortical plasticity earlier than does AO–MI or ES alone and that an individual’s imagery ability plays an important role in inducing cortical excitability changes following AO–MI + ES.

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Acknowledgements

This work was partially supported by grants from the Funds for a Grant-in-Aid for Young Scientists (15K16370 and 18K17723) to Tomofumi Yamaguchi and JSPS KAKENHI Grant Number JP16K19521 to Michiyuki Kawakami.

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Authors and Affiliations

  1. Tokyo Bay Rehabilitation Hospital, 4-1-1 Yatsu, Narashino-shi, Chiba, 275-0026, Japan

    Takahito Yasui, Yoko Takahashi, Kunitsugu Kondo & Michiyuki Kawakami

  2. Department of Physical Therapy, Yamagata Prefectural University of Health Sciences, 260 Kamiyanagi, Yamagata-shi, Yamagata, 990-2212, Japan

    Tomofumi Yamaguchi

  3. JSPS Postdoctoral Fellow for Research Abroad, 5-3-1 Kojimachi, Chiyoda-ku, Tokyo, 102-0083, Japan

    Tomofumi Yamaguchi

  4. Department of Neuroscience, University of Copenhagen, Blegdamsvej 3, 2200, Copenhagen N, Denmark

    Tomofumi Yamaguchi

  5. Department of Rehabilitation Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan

    Tomofumi Yamaguchi, Yoko Takahashi & Michiyuki Kawakami

  6. Faculty of Rehabilitation, School of Health Sciences, Fujita Health University, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake-shi, Aichi, 470-1192, Japan

    Shigeo Tanabe & Tsuyoshi Tatemoto

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  1. Takahito Yasui
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  2. Tomofumi Yamaguchi
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Correspondence to Tomofumi Yamaguchi.

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Yasui, T., Yamaguchi, T., Tanabe, S. et al. Time course of changes in corticospinal excitability induced by motor imagery during action observation combined with peripheral nerve electrical stimulation. Exp Brain Res 237, 637–645 (2019). https://doi.org/10.1007/s00221-018-5454-5

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