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Is the human masticatory system devoid of recurrent inhibition?

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An Erratum to this article was published on 11 January 2007

An Erratum to this article was published on 11 January 2007

Abstract

The aim of the present study was to investigate the existence or otherwise of a functional recurrent inhibitory system (Renshaw cell system) in the motoneurons that innervate human masticatory muscles. In a previous study, l-acetylcarnitine (l-Ac), a substance known to potentiate recurrent inhibition in humans was found to alter, in a specific way, the discharge variability, and the synchronous activity of motor units depending on the presence or absence of recurrent inhibition in the corresponding motoneuron pool. Using a similar paradigm, we have recorded the tonic discharge activity of motor unit pairs from the masseter muscle during voluntary isometric contraction while subjects were undergoing continuous intravenous saline (SAL, NaCl 0.9%) perfusion. Following a brief baseline-recording period, the subjects were given a test injection of either l-Ac or isotonic saline (SAL) in a double blind manner. The variability, synchronization, and coherence between the motor unit discharges were analysed during three successive periods: pre-injection, during injection, and post-injection, each lasting 2–3 min. Neither l-Ac nor SAL injection induced a significant change in the inter-spike interval (ISI) or the coefficient of variation of the ISIs in the motor units tested. There were also no significant changes in the pattern of synchronous activity or in the coherence, which reflects the common frequency content of the unit discharges. Reminiscent of what had been observed previously with motoneurons without recurrent inhibition in the Abductor Digitorum Minimi muscle, the lack of effects of l-Ac injection on the firing behaviour of masseter motoneurons may suggest that classical Renshaw cell inhibition is lacking in this motoneuron pool.

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Acknowledgments

This research was supported by grants from the National Health and Medical Research Council of Australia; and the Italian MIUR and Istituto Riabilitazione Fisiomedica Loretana (CB, Italy).

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Authors and Affiliations

  1. Research Centre for Human Movement Control, Discipline of Physiology, School of Molecular and Biomedical Sciences, University of Adelaide, Adelaide, SA, 5005, Australia

    K. S. Türker & P. F. Sowman

  2. P3M-CNRS, 31 Chemin Joseph Aiguier, 13402, Marseille Cedex 20, France

    A. Schmied & J. P. Vedel

  3. Unità di Neurofisiologia Clinica, Università degli Studi di Siena, Dipartimento di Scienze Neurologiche e del Comportamento, Policlinico Universitario Le Scotte, viale Bracci, 53100, Siena, Italy

    A. Rossi & R. Mazzocchio

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  1. K. S. Türker
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Correspondence to K. S. Türker.

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An erratum to this article can be found at http://dx.doi.org/10.1007/s00221-006-0837-4

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Türker, K.S., Schmied, A., Rossi, A. et al. Is the human masticatory system devoid of recurrent inhibition?. Exp Brain Res 179, 131–144 (2007). https://doi.org/10.1007/s00221-006-0774-2

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  • DOI: https://doi.org/10.1007/s00221-006-0774-2

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