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Experimental skin pain and muscle pain induce distinct changes in human trigeminal motoneuronal excitability

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Abstract

Seeking information on the physiological properties of the trigeminal motoneuronal pool we investigated changes in the excitability of trigeminal motor system induced by two types of experimental pain (muscle and skin). In one session, we studied the effect of muscle pain induced by hypertonic saline infusion into the masseter muscle on the recovery cycle of the heteronymous H-reflex in the temporalis muscle and the homonymous silent period (SP) in the masseter muscle, both elicited by stimulation of the masseteric nerve in ten-healthy subjects. In another session, we studied the effect of laser stimuli applied to the perioral region, at conditioning intervals from 20 to 160 ms, on the temporalis H-reflex and masseter SP in nine healthy subjects. Whereas laser-induced skin pain significantly inhibited the temporalis H-reflex and facilitated the masseter SP (P < 0.01), muscle pain left the time course of the temporalis H-reflex and masseter SP unchanged (P > 0.05). The timing of temporalis H-reflex suppression and masseter-SP enhancement induced by laser stimuli indicates that facial skin nociceptors inhibit trigeminal motoneurones via multysynaptic reflex pathways. Hypertonic saline, a stimulus that predominantly activates group III and IV afferents, left both variables reflecting trigeminal motoneuron excitability unchanged. Due to the differences between the two experimental models, we cannot conclude that such inhibitory reflex pathway does not exist from muscle nociceptors to trigeminal motoneurones.

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Authors and Affiliations

  1. Department of Neurological Sciences, University “La Sapienza”, Viale Università, 30, 00185, Rome, Italy

    A. Truini, A. Romaniello, F. Galeotti & G. Cruccu

  2. Department of Clinical Oral Physiology, School of Dentistry, University of Aarhus, Aarhus, Denmark

    P. Svensson

  3. Center for Sensory-Motor Interaction, Orofacial Pain Laboratory, Aalborg University, Aalborg, Denmark

    P. Svensson, T. Graven-Nielsen, K. Wang & L. Arendt-Nielsen

Authors
  1. A. Truini
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  2. A. Romaniello
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  3. P. Svensson
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  4. F. Galeotti
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  5. T. Graven-Nielsen
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  6. K. Wang
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  7. G. Cruccu
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  8. L. Arendt-Nielsen
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Correspondence to A. Truini.

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Truini, A., Romaniello, A., Svensson, P. et al. Experimental skin pain and muscle pain induce distinct changes in human trigeminal motoneuronal excitability. Exp Brain Res 174, 622–629 (2006). https://doi.org/10.1007/s00221-006-0508-5

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  • DOI: https://doi.org/10.1007/s00221-006-0508-5

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