Abstract
The review covers recent developments in which quantum dots (QDs) are combined with electrodes for detection of analytes. Special focus will be on the generation of photocurrents and the possibility of spatially resolved, light-directed analysis. Different modes for combining biochemical reactions with QDs will be discussed. Other applications involve the use of QDs as labels in binding analysis. Different methods have been developed for read-out. In addition to photocurrent analysis, voltammetric detection of metals and electrochemiluminescence (ECL) can be used. In the latter, light is the sensor signal. ECL-based systems combine the advantage of very sensitive analytical detection with rather simple instrumentation.
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Abbreviations
- AChE:
-
Acetycholine esterase
- ALP:
-
Alkaline phosphatase
- ATP:
-
Adenosine triphosphate
- BDT:
-
1,4-Dithiobenzene
- CCD:
-
Charge-coupled device
- CNTs:
-
Carbon nanotubes
- [Co(Phen)3Cl2]:
-
Cobalt phenanthroline chloride
- CRET:
-
Chemical resonance energy transfer
- Cy5:
-
Fluorescence dye (for Cy5 Ex = 650 nm; Em = 670 nm)
- cyt c:
-
Cytochrome c
- DET:
-
Direct (heterogeneous) electron transfer
- ECL:
-
Electrochemiluminescence
- ERET:
-
Electrochemical resonance energy transfer
- FRET:
-
Förster resonance energy transfer
- GDH:
-
Glucose dehydrogenase
- GOD:
-
Glucose oxidase
- HEPES:
-
4-(2-Hydroxyethyl)-1-piperazineethanesulfonic acid
- HRP:
-
Horseradish peroxidase
- IgG:
-
Immunoglobulin G
- ITO:
-
Indium tin oxide
- LAPS:
-
Light-addressable potentiometric sensors
- LDH:
-
Lactate dehydrogenase
- NAD+/NADH:
-
Nicotinamide adenine dinucleotide
- NPs:
-
Nanoparticles
- NR:
-
Nitrate reductase
- PAH:
-
Polyallylamine hydrochloride
- pAP:
-
p-Aminophenol
- pAPP:
-
p-Aminophenylphosphate
- PSA:
-
Prostate-specific antigen
- QDs:
-
Quantum dots
- [Ru(bpy)3]2+ :
-
Ruthenium bipyridine complex
- TOPO:
-
Trioctylphosphine oxide
- TPrA:
-
Tri-n-propylamine
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Published in the topical collection Bioelectroanalysis with guest editors Nicolas Plumeré, Magdalena Gebala, and Wolfgang Schuhmann.
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Lisdat, F., Schäfer, D. & Kapp, A. Quantum dots on electrodes—new tools for bioelectroanalysis. Anal Bioanal Chem 405, 3739–3752 (2013). https://doi.org/10.1007/s00216-013-6789-1
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DOI: https://doi.org/10.1007/s00216-013-6789-1