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Single-walled carbon nanotube as an effective quencher

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Abstract

Over the past few years, single-walled carbon nanotubes (SWNTs) have been the focus of intense research motivated by their unique physical and chemical properties. This review specifically summarizes recent progress in the development of fluorescence biosensors that integrate the quenching property of SWNTs and the recognition property of functional nucleic acids. SWNTs are substantially different from organic quenchers, showing superior quenching efficiency for a variety of fluorophores, with low background and high signal-to-noise ratio, as well as other advantages derived from the nanomaterial itself. As the second key component of biosensors, functional nucleic acids can bind to either their complementary DNA or a target molecule with the ability to recognize a broad range of targets from metal ions to organic molecules, proteins, and even live cells. By taking advantage of the strengths and properties of both SWNTs and nucleic acid based aptamers, a series of fluorescence biosensors have been designed and fabricated for the detection of a broad range of analytes with high selectivity and sensitivity.

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Authors and Affiliations

  1. Center for Research at Bio/nano Interface, Department of Chemistry, Shands Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, FL, 32611-7200, USA

    Zhi Zhu, Mingxu You, Xiaoling Zhang, Yanrong Wu & Weihong Tan

  2. Biomedical Engineering Center, Hunan University, Changsha, Hunan, 410082, China

    Ronghua Yang & Weihong Tan

  3. Department of Chemistry, School of Science, Beijing Institute of Technology, 100081, Beijing, People’s Republic of China

    Xiaoling Zhang

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  1. Zhi Zhu
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Correspondence to Weihong Tan.

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Zhu, Z., Yang, R., You, M. et al. Single-walled carbon nanotube as an effective quencher. Anal Bioanal Chem 396, 73–83 (2010). https://doi.org/10.1007/s00216-009-3192-z

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