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Effects of rosmarinic acid on nervous system disorders: an updated review

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Abstract

Nowadays, the worldwide interest is growing to use medicinal plants and their active constituents to develop new potent medicines with fewer side effects. Precise dietary compounds have prospective beneficial applications for various neurodegenerative ailments. Rosmarinic acid is a polyphenol and is detectable most primarily in many Lamiaceae families, for instance, Rosmarinus officinalis also called rosemary. This review prepared a broad and updated literature review on rosmarinic acid elucidating its biological activities on some nervous system disorders. Rosmarinic acid has significant antinociceptive, neuroprotective, and neuroregenerative effects. In this regard, we classified and discussed our findings in different nervous system disorders including Alzheimer’s disease, epilepsy, depression, Huntington’s disease, familial amyotrophic lateral sclerosis, Parkinson’s disease, cerebral ischemia/reperfusion injury, spinal cord injury, stress, anxiety, and pain.

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References

  • Airoldi C, Sironi E, Dias C, Marcelo F, Martins A, Rauter AP, Nicotra F, Jimenez-Barbero J (2013) Natural compounds against Alzheimer’s disease: molecular recognition of Abeta1-42 peptide by Salvia sclareoides extract and its major component, rosmarinic acid, as investigated by NMR. Chem Asian J 8:596–602

    Article  CAS  PubMed  Google Scholar 

  • Alkam T, Nitta A, Mizoguchi H, Itoh A, Nabeshima T (2007) A natural scavenger of peroxynitrites, rosmarinic acid, protects against impairment of memory induced by Abeta (25–35). Behav Brain Res 180:139–145

    Article  CAS  PubMed  Google Scholar 

  • Alonso A, Grundke-Iqbal I, Iqbal K (1996) Alzheimer’s disease hyperphosphorylated tau sequesters normal tau into tangles of filaments and disassembles microtubules. Nat Med 2:783–787

    Article  CAS  PubMed  Google Scholar 

  • Al-Sereiti MR, Abu-Amer KM, Sen P (1999) Pharmacology of rosemary (Rosmarinus officinalis Linn.) and its therapeutic potentials. Indian J Exp Biol 37:124–130

    CAS  PubMed  Google Scholar 

  • Amaro S, Chamorro A (2011) Translational stroke research of the combination of thrombolysis and antioxidant therapy. Stroke 42:1495–1499

    Article  CAS  PubMed  Google Scholar 

  • Arriagada PV, Growdon JH, Hedley-Whyte ET, Hyman BT (1992) Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer’s disease. Neurology 42:631–639

    Article  CAS  PubMed  Google Scholar 

  • Awad R, Muhammad A, Durst T, Trudeau VL, Arnason JT (2009) Bioassay-guided fractionation of lemon balm (Melissa officinalis L.) using an in vitro measure of GABA transaminase activity. Phytother Res 23:1075–1081

    Article  CAS  PubMed  Google Scholar 

  • Bains M, Hall ED (2012) Antioxidant therapies in traumatic brain and spinal cord injury. Biochim Biophys Acta 1822:675–684

    Article  CAS  PubMed  Google Scholar 

  • Bazan NG, Colangelo V, Lukiw WJ (2002) Prostaglandins and other lipid mediators in Alzheimer’s disease. Prostaglandins Other Lipid Mediat 68-69:197–210

    Article  CAS  PubMed  Google Scholar 

  • Beal MF, Ferrante RJ (2004) Experimental therapeutics in transgenic mouse models of Huntington’s disease. Nat Rev Neurosci 5:373–384

    Article  CAS  PubMed  Google Scholar 

  • Ben‐Menachem E (2011) Mechanism of action of vigabatrin: correcting misperceptions. Acta Neurol Scand 124:5–15.

  • Bhatt R, Singh D, Prakash A, Mishra N (2014) Development, characterization and nasal delivery of rosmarinic acid-loaded solid lipid nanoparticles for the effective management of Huntington’s disease. Drug Deliv 22:931–939

    Article  PubMed  CAS  Google Scholar 

  • Blum D, Torch S, Lambeng N, Nissou M, Benabid AL, Sadoul R, Verna JM (2001) Molecular pathways involved in the neurotoxicity of 6- OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease. Prog Neurobiol 65:135–172

    Article  CAS  PubMed  Google Scholar 

  • Bonelli RM, Hofmann P (2004) A review of the treatment options for Huntington’s disease. Expert Opin Pharmacother 5:767–776

    Article  CAS  PubMed  Google Scholar 

  • Boonyarikpunchai W, Sukrong S, Towiwat P (2014) Antinociceptive and anti-inflammatory effects of rosmarinic acid isolated from Thunbergia laurifolia Lindl. Pharmacol Biochem Behav 51:1087–1090

    Google Scholar 

  • Bors W, Michel C, Stetmaier K, Lu Y, Foo L (2004) Antioxidant mechanisms of polyphenolic caffeic acid oligomers, constituents of Salvia officinalis. Biol Res 37:301–311

    Article  PubMed  Google Scholar 

  • Braidy N, Matin A, Rossi F, Chinain M, Laurent D, Guillemin GJ (2014) Neuroprotective effects of rosmarinic acid on ciguatoxin in primary human neurons. Neurotox Res 25:226–234

    Article  CAS  PubMed  Google Scholar 

  • Bramblett GT, Goedert M, Jakes R, Merrick SE, Trojanowski JQ, Lee VM (1993) Abnormal tau phosphorylation at Ser396 in Alzheimer’s disease recapitulates development and contributes to reduced microtubule binding. Neuron 10:1089–1099

    Article  CAS  PubMed  Google Scholar 

  • Brondello JM, Brunet A, Pouysségur J, McKenzie FR (1997) The dual specificity mitogen-activated protein kinase phosphatase-1 and -2 are induced by the p42/p44 MAPK cascade. J Biol Chem 272:1368–1376

    Article  CAS  PubMed  Google Scholar 

  • Broussalis E, Killer M, McCoy M, Harrer A, Trinka E, Kraus J (2012) Current therapies in ischemic stroke. Part A. Recent developments in acute stroke treatment and in stroke prevention. Drug Discov Today 17:296–309

    Article  CAS  PubMed  Google Scholar 

  • Chen N, Gao Y, Yan N, Liu C, Zhang JG, Xing WM, Kong DM, Meng FG (2014) High-frequency stimulation of the hippocampus protects against seizure activity and hippocampal neuronal apoptosis induced by kainic acid administration in macaques. Neuroscience 256:370–378

    Article  CAS  PubMed  Google Scholar 

  • Chen Y, Wang H, Zhang R, Wang H, Peng Z, Sun R, Tan Q (2012) Microinjection of sanguinarine into the ventrolateral orbital cortex inhibits MKP-1 and exerts an anti-depressant-like effect in rats. Neurosci Lett 506:327–331

    Article  CAS  PubMed  Google Scholar 

  • Choi HR, Choi JS, Han YN, Bae SJ, Chung HY (2002) Peroxynitrite scavenging activity of herb extracts. Phytother Res 16:364–367

    Article  CAS  PubMed  Google Scholar 

  • Choo AM, Liu J, Dvorak M, Tetzlaff W, Oxland TR (2008) Secondary pathology following contusion, dislocation, and distraction spinal cord injuries. Exp Neurol 212:490–506

    Article  PubMed  Google Scholar 

  • Clapp JD, Beck JG, Palyo SA, Grant DM (2008) An examination of the synergy of pain and PTSD on quality of life: additive or multiplicative effects? Pain 138:301–309

    Article  PubMed  PubMed Central  Google Scholar 

  • Clayton DF, George JM (1999) Synucleins in synaptic plasticity and neurodegenerative disorders. J Neurosci Res 58:120–129

    Article  CAS  PubMed  Google Scholar 

  • Coelho VR, Vieira CG, de Souza LP, da Silva LL, Pflüger P, Regner GG, Papke DK, Picada JN, Pereira P (2016) Behavioral and genotoxic evaluation of rosmarinic and caffeicacid in acute seizure models induced by pentylenetetrazole and pilocarpine in mice. Naunyn Schmiedeberg's Arch Pharmacol 389:1195–1203

    Article  CAS  Google Scholar 

  • Coelho VR, Vieira CG, de Souza LP, Moysés F, Basso C, Papke DK, Pires TR, Siqueira IR, Picada JN, Pereira P (2015) Antiepileptogenic, antioxidant and genotoxic evaluation of rosmarinic acid and its metabolite caffeic acid in mice. Life Sci 1:65–71

    Article  CAS  Google Scholar 

  • Connelly AE, Tucker AJ, Tulk H, Catapang M, Chapman L, Sheikh N, Yurchenko S, Fletcher R, Kott LS, Duncan AM, Wright AJ (2014) High-rosmarinic acid spearmint tea in the management of knee osteoarthritis symptoms. J Med Food 17:1361–1367

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Costigan M, Scholz J, Woolf CJ (2009) Neuropathic pain: a maladaptive response of the nervous system to damage. Annu Rev Neurosci 32:1–32

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Dagytė G, Den Boer JA, Trentani A (2011) The cholinergic system and depression. Behav Brain Res 221:574–582

    Article  PubMed  CAS  Google Scholar 

  • David DC, Hauptmann S, Scherping I, Schuessel K, Keil U, Rizzu P, Ravid R, Dröse S, Brandt U, Müller WE, Eckert A, Götz J (2005) Proteomic and functional analyses reveal a mitochondrial dysfunction in P301L tau transgenic mice. J Biol Chem 280:23802–23814

    Article  CAS  PubMed  Google Scholar 

  • Dou F, Netzer WJ, Tanemura K, Li F, Hartl FU, Takashima A, Gouras GK, Greengard P, Xu H (2003) Chaperones increase association of tau protein with microtubules. Proc Natl Acad Sci U S A 100:721–726

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Du T, Li L, Song N, Xie J, Jiang H (2010a) Rosmarinic acid antagonized 1-methyl-4-phenylpyridinium (MPP+)-induced neurotoxicity in MES23.5 dopaminergic cells. Int J Toxicol 29:625–633

    Article  CAS  PubMed  Google Scholar 

  • Du T, Song N, Xie J, Jiang H (2010b) Iron chelation of rosmarinic acid. Med J Qilu 25:399–401

    Google Scholar 

  • Duman RS, Malberg J, Thome J (1999) Neural plasticity to stress and antidepressant treatment. Biol Psychiatry 46:1181–1191

    Article  CAS  PubMed  Google Scholar 

  • Duric V, Banasr M, Licznerski P, Schmidt HD, Stockmeier CA, Simen AA, Newton SS, Duman RS (2010) A negative regulator of MAP kinase causes depressive behavior. Nat Med 16:1328–1332

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • El Alaoui C, Chemin J, Fechtali T, Lory P (2017) Modulation of T-type Ca2+ channels by Lavender and Rosemary extracts. PLoS One 12:e0186864

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • El Omri A, Han J, Yamada P, Kawada K, Ben Abdrabbah M, Isoda H (2010) Rosmarinus officinalis polyphenols activate cholinergic activities in PC12 cells through phosphorylation of ERK1/2. J Ethnopharmacol 131:451–458

    Article  PubMed  CAS  Google Scholar 

  • Engel J (2001) A proposed diagnostic scheme for people with epileptic seizures and with epilepsy: report of the ILAE task force on classification and terminology. Epilepsia 42:796–803

    Article  PubMed  Google Scholar 

  • Engelhardt JI, Appel SH (1990) IgG reactivity in the spinal cord and motor cortex in amyotrophic lateral sclerosis. Arch Neurol 47:1210–1216

    Article  CAS  PubMed  Google Scholar 

  • Fadel O, El Kirat K, Morandat S (2011) The natural antioxidant rosmarinic acid spontaneously penetrates membranes to inhibit lipid peroxidation in situ. Biochim Biophys Acta 1808:2973–2980

    Article  CAS  PubMed  Google Scholar 

  • Fallarini S, Miglio G, Paoletti T, Minassi A, Amoruso A, Bardelli C, Brunelleschi S, Lombardi G (2009) Clovamide and rosmarinic acid induce neuroprotective effects in in vitro models of neuronal death. Br J Pharmacol 157:1072–1084

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ferguson TA, Elman LB (2007) Clinical presentation and diagnosis of amyotrophic lateral sclerosis. Neurorehabilitation 22:409–416

    Article  PubMed  Google Scholar 

  • Fisher RS, van Emde BW, Blume W, Elger C, Genton P, Lee P, Engel J Jr (2005) Epileptic seizures and epilepsy: definitions proposed by the international league against epilepsy (ILAE) and the international bureau for epilepsy (IBE). Epilepsia 46:470–472

    Article  PubMed  Google Scholar 

  • Fleischer A, Ghadiri A, Dessauge F, Duhamel M, Rebollo MP, Alvarez-Franco F, Rebollo A (2006) Modulating apoptosis as a target for effective therapy. Mol Immunol 43:1065–1079

    Article  CAS  PubMed  Google Scholar 

  • Fonteles AA, de Souza CM, de Sousa Neves JC, Menezes AP, Santos do Carmo MR, Fernandes FD, de Araujo PR, de Andrade GM (2016) Rosmarinic acid prevents against memory deficits in ischemic mice. Behav Brain Res 15:91–103

    Article  CAS  Google Scholar 

  • Fujiwara H, Hasegawa M, Dohmae N, Kawashima A, Masliah E, Goldberg MS, Shen J, Takio K, Iwatsubo T (2002) α-Synuclein is phosphorylated in synucleinopathy lesions. Nat Cell Biol 4:160–164

    Article  CAS  PubMed  Google Scholar 

  • Gamaro GD, Suyenaga E, Borsoi M, Lermen J, Pereira P, Ardenghi P (2011) Effect of rosmarinic and caffeic acids on inflammatory and nociception process in rats. ISRN Pharmacol 2011:451682

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Gao YJ, Ji RR (2010) Targeting astrocyte signaling for chronic pain. Neurotherapeutics 7:482–493

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ghaffari H, Venkataramana M, Jalali Ghassam B, Chandra Nayaka S, Nataraju A, Geetha NP, Prakash HS (2014) Rosmarinic acid mediated neuroprotective effects against HO-induced neuronal cell damage in N2A cells. Life Sci 113:7–13

    Article  CAS  PubMed  Google Scholar 

  • Ghasemzadeh Rahbardar M, Amin B, Mehri S, Mirnajafi-Zadeh SJ, Hosseinzadeh H (2017) Anti-inflammatory effects of ethanolic extract of Rosmarinus officinalis L. and rosmarinic acid in a rat model of neuropathic pain. Biomed Pharmacother 86:441–449

    Article  CAS  PubMed  Google Scholar 

  • Govindaraj J, Sorimuthu Pillai S (2015) Rosmarinic acid modulates the antioxidant status and protects pancreatic tissues from glucolipotoxicity mediated oxidative stress in high-fat diet: streptozotocin-induced diabetic rats. Mol Cell Biochem 404:143–159

    Article  CAS  PubMed  Google Scholar 

  • Grigoletto J, Oliveira CV, Grauncke AC, Souza TL, Souto NS, Freitas ML, Furian AF, Santos AR, Oliveira MS (2016) Rosmarinic acid is anticonvulsant against seizures induced by pentylenetetrazol and pilocarpine in mice. Epilepsy Behav 62:27–34

    Article  PubMed  Google Scholar 

  • Gudesblatt M, Daniel T (2012) Huntington’s disease: a clinical review. Rev Neurol:S1–S8. Roos RA (2010) Huntington’s disease: a clinical review. Orphanet J Rare Dis 5:40. https://doi.org/10.1007/s00210-020-01935-w

  • Guginski G, Luiz AP, Silva MD, Massaro M, Martins DF, Chaves J, Mattos RW, Silveira D, Ferreira VM, Calixto JB, Santos AR (2009) Mechanisms involved in the antinociception caused by ethanolic extract obtained from the leaves of Melissa officinalis (lemon balm) in mice. Pharmacol Biochem Behav 93:10–16

    Article  CAS  PubMed  Google Scholar 

  • Haass C, Selkoe DJ (2007) Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer amyloid peptide. Nat Rev Mol Cell Biol 8:101–112

    Article  CAS  PubMed  Google Scholar 

  • Hall ED, Oostveen JA, Gurney ME (1998) Relationship of microglial and astrocytic activation to disease onset and progression in a transgenic model of familial ALS. Glia 23:249–256

    Article  CAS  PubMed  Google Scholar 

  • Hamaguchi T, Ono K, Murase A, Yamada M (2009) Phenolic compounds prevent Alzheimer’s pathology through different effects on the amyloid-beta aggregation pathway. Am J Pathol 175:2557–2565

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hasanein P, Mahtaj AK (2015) Ameliorative effect of rosmarinic acid on scopolamine-induced memory impairment in rats. Neurosci Lett 12:23–27

    Article  CAS  Google Scholar 

  • Hasanein P, Mohammad Zaheri L (2014) Effects of rosmarinic acid on an experimental model of painful diabetic neuropathy in rats. Pharm Biol 52:1398–1402

    Article  CAS  PubMed  Google Scholar 

  • Hasanein P, Seifi R, Hajinezhad MR, Emamjomeh A (2017) Rosmarinic acid protects against chronic ethanol-induced learning and memory deficits in rats. Nutr Neurosci 20:547–554

    Article  CAS  PubMed  Google Scholar 

  • Hausmann ON (2003) Post-traumatic inflammation following spinal cord injury. Spinal Cord 41:369–378

    Article  CAS  PubMed  Google Scholar 

  • Hebert LE, Beckett LA, Scherr PA, Evans DA (2001) Annual incidence of Alzheimer disease in the United States projected to the years 2000 through 2050. Alzheimer Dis Assoc Disord 15:169–173

    Article  CAS  PubMed  Google Scholar 

  • Hebert LE, Scherr PA, Bienias JL, Bennett DA, Evans DA (2003) Alzheimer disease in the US population: prevalence estimates using the 2000 census. Arch Neurol 60:1119–1122

    Article  PubMed  Google Scholar 

  • Hendriksen H, Prins J, Olivier B, Oosting RS (2010) Environmental enrichment induces behavioral recovery and enhanced hippocampal cell proliferation in an antidepressant-resistant animal model for PTSD. PLoS One 5:e11943

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Henkel JS, Engelhardt JI, Siklos L, Simpson EP, Kim SH, Pan T, Goodman JC, Siddique T, Beers DR, Appel SH (2004) Presence of dendritic cells, MCP-1, and activated microglia/macrophages in amyotrophic lateral sclerosis spinal cord tissue. Ann Neurol 55:221–235

    Article  CAS  PubMed  Google Scholar 

  • Hervera A, Leánez S, Negrete R, Motterlini R, Pol O (2012) Carbon monoxide reduces neuropathic pain and spinal microglial activation by inhibiting nitric oxide synthesis in mice. PLoS One 7:e43693

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Herzberg D, Strobel P, Chihuailaf R, Ramirez-Reveco A, Müller H, Werner M, Bustamante H (2019) Spinal reactive oxygen species and oxidative damage mediate chronic pain in lame dairy cows. Animals (Basel) 9(9):17

    Google Scholar 

  • Hui Yin Y, Ahmad N, Makmor-Bakry M (2013) Pathogenesis of epilepsy: challenges in animal models. Iran J Basic Med Sci 16:1119–1132

    PubMed  PubMed Central  Google Scholar 

  • Ito N, Yabe T, Gamo Y, Nagai T, Oikawa T, Yamada H, Hanawa T (2008) Rosmarinic acid from Perillae Herba produces an antidepressant-like effect in mice through cell proliferation in the hippocampus. Biol Pharm Bull 31:1376–1380

    Article  CAS  PubMed  Google Scholar 

  • Iuvone T, De Filippis D, Esposito G, D'Amico A, Izzo AA (2006) The spice sage and its active ingredient rosmarinic acid protect PC12 cells from amyloid-β peptide-induced neurotoxicity. J Pharmacol Exp Ther 317:1143–1149

  • Ji RR, Xu ZZ, Wang X, Lo EH (2009) Matrix metalloprotease regulation of neuropathic pain. Trends Pharmacol Sci 30:336–340

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Jiang H, Song N, Wang J, Ren LY, Xie JX (2007) Peripheral iron dextran induced degeneration of dopaminergic neurons in rat substantia nigra. Neurochem Int 51:32–36

    Article  CAS  PubMed  Google Scholar 

  • Jin X, Liu P, Yang F, Zhang YH, Miao D (2013) Rosmarinic acid ameliorates depressive-like behaviors in a rat model of CUS and up-regulates BDNF levels in the hippocampus and hippocampal-derived astrocytes. Neurochem Res 38:1828–1837

    Article  CAS  PubMed  Google Scholar 

  • Jinwal UK, Trotter JH, Abisambra JF, Koren J, Lawson LY 3rd, Vestal GD, O’Leary JC, Johnson AG 3rd, Jin Y, Jones JR, Li Q, Weeber EJ, Dickey CA (2011) The Hsp90 kinase cochaperone Cdc37 regulates tau stability and phosphorylation dynamics. J Biol Chem 286:16976–16983

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Johansen JS, Harris AK, Rychly DJ, Ergul A (2005) Oxidative stress and the use of antioxidants in diabetes. Cardiovasc Diabetol 29:4–5

    Google Scholar 

  • Kanazawa I (2001) How do neurons die in neurodegenerative diseases? Trends Mol Med 7:339–344

    Article  CAS  PubMed  Google Scholar 

  • Kang M, Yun S, Won J (2003) Rosmarinic acid inhibits Ca2+-dependent pathways of T-cell antigen receptor-mediated signaling by inhibiting the PLC-gamma 1 and Itk activity. Blood 101:3534–3542

    Article  CAS  PubMed  Google Scholar 

  • Kantar-Gok D, Hidisoglu E, Er H, Acun AD, Olgar Y, Yargıcoglu P (2017) Changes of auditory event-related potentials in ovariectomized rats injected with D-galactose: protective role of rosmarinic acid. Neurotoxicology 62:64–74

    Article  CAS  PubMed  Google Scholar 

  • Kaster MP, Gadotti VM, Calixto JB, Santos AR, Rodrigues AL (2012) Depressive-like behavior induced by tumor necrosis factor-alpha in mice. Neuropharmacology 62:419–426

    Article  CAS  PubMed  Google Scholar 

  • Kessler RC, Berglund P, Demler O, Jin R, Merikangas KR, Walters EE (2005) Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch Gen Psychiatry 62:593–602

    Article  PubMed  Google Scholar 

  • Khamse S, Sadr SS, Roghani M, Hasanzadeh G, Mohammadian M (2015) Rosmarinic acid exerts a neuroprotective effect in the kainate rat model of temporal lobe epilepsy: underlying mechanisms. Pharm Biol 53:1818–1825

    Article  CAS  PubMed  Google Scholar 

  • Khan S, Ahmad K, Alshammari EM, Adnan M, Baig MH, Lohani M, Somvanshi P, Haque S (2015) Implication of caspase-3 as a common therapeutic target for multineurodegenerative disorders and its inhibition using nonpeptidyl natural compounds. Biomed Res Int 2015:379817

    PubMed  PubMed Central  Google Scholar 

  • Kikuchi A, Shimizu K, Nibuya M, Hiramoto T, Kanda Y, Tanaka T, Watanabe Y, Takahashi Y, Nomura S (2008) Relationship between post-traumatic stress disorder-like behavior and reduction of hippocampal 5-bromo-2′-deoxyuridine-positive cells after inescapable shock in rats. Psychiatry Clin Neurosci 62:713–720

    Article  PubMed  Google Scholar 

  • Kim JJ, Lee HJ, Welday AC, Song E, Cho J, Sharp PE, Jung MW, Blair HT (2007) Stress-induced alterations in hippocampal plasticity, place cells, and spatial memory. Proc Natl Acad Sci U S A 104:18297–18302

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kim M, Shin MS, Lee JM, Cho HS, Kim CJ, Kim YJ, Choi HR, Jeon JW (2014) Inhibitory effects of isoquinoline alkaloid berberine on ischemia-induced apoptosis via activation of phosphoinositide 3-kinase/protein kinase B signaling pathway. Int Neurourol J 18:115–125

    Article  PubMed  PubMed Central  Google Scholar 

  • Kim ST, Doo AR, Kim SN, Kim SY, Kim YY, Kim JH, Lee H, Yin CS, Park HJ (2012) Acupuncture suppresses kainic acid-induced neuronal death and inflammatory events in mouse hippocampus. J Physiol Sci 62:377–383

    Article  CAS  PubMed  Google Scholar 

  • Kriz J, Nguyen MD, Julien JP (2002) Minocycline slows disease progression in a mouse model of amyotrophic lateral sclerosis. Neurobiol Dis 10:268–278

    Article  CAS  PubMed  Google Scholar 

  • Kuo YC, Rajesh R (2017) Targeted delivery of rosmarinic acid across the blood–brain barrier for neuronal rescue using polyacrylamide-chitosan-poly (lactide-coglycolide) nanoparticles with surface cross-reacting material 197 and apolipoprotein E. Int J Pharm 528:228–241

    Article  CAS  PubMed  Google Scholar 

  • Lakhan SE, Avramut M (2012) Matrix metalloproteinases in neuropathic pain and migraine: friends, enemies, and therapeutic targets. Pain Res Treat 2012:952906

    PubMed  PubMed Central  Google Scholar 

  • Lee HJ, Cho HS, Park E, Kim S, Lee SY, Kim CS, Kim DK, Kim SJ, Chun HS (2008) Rosmarinic acid protects human dopaminergic neuronal cells against hydrogen peroxide-induced apoptosis. Toxicology 250:109–115

    Article  CAS  PubMed  Google Scholar 

  • Lee HJ, Kim JW, Yim SV, Kim MJ, Kim SA, Kim YJ, Kim CJ, Chung JH (2001) Fluoxetine enhances cell proliferation and prevents apoptosis in dentate gyrus of maternally separated rats. Mol Psychiatry 610:725–728

    Article  Google Scholar 

  • Lee KG, Shibamoto T, Takeoka GR, Lee SE, Kim JH, Park BS (2003) Inhibitory effects of plant-derived flavonoids and phenolic acids on malonaldehyde formation from ethyl arachidonate. J Agric Food Chem 51:7203–7207

    Article  CAS  PubMed  Google Scholar 

  • Leong SL, Pham CL, Galatis D, Fodero-Tavoletti MT, Perez K, Hill AF, Masters CL, Ali FE, Barnham KJ, Cappai R (2009) Formation of dopamine-mediated synuclein-soluble oligomers requires methionine oxidation. Free Radic Biol Med 46:1328–1337

    Article  CAS  PubMed  Google Scholar 

  • Li JY, Plomann M, Brundin P (2003) Huntington’s disease: a synaptopathy? Trends Mol Med 9:414–420

    Article  CAS  PubMed  Google Scholar 

  • Li XM, Han F, Liu DJ, Shi YX (2010) Single-prolonged stress induced mitochondrial-dependent apoptosis in hippocampus in the rat model of post-traumatic stress disorder. J Chem Neuroanat 40:248–255

    Article  CAS  PubMed  Google Scholar 

  • Liang X, Wang Q, Hand T, Wu L, Breyer RM, Montine TJ, Andreasson K (2005) Deletion of the prostaglandin E2 EP2 receptor reduces oxidative damage and amyloid burden in a model of Alzheimer’s disease. J Neurosci 25:10180–10187

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Liang Z, Xu Y, Wen X, Nie H, Hu T, Yang X, Chu X, Yang J, Deng X, He J (2016) Rosmarinic acid attenuates airway inflammation and hyper responsiveness in a murine model of asthma. Molecules 21(6):13

    Google Scholar 

  • Lin SH, Chou ML, Chen WC, Lai YS, Lu KH, Hao CW, Sheen LY (2015) A medicinal herb Melissa officinalis L. ameliorates depressive-like behavior of rats in the forced swimming test via regulating the serotonergic neurotransmitter. J Ethnopharmacol 175:266–272

    Article  CAS  PubMed  Google Scholar 

  • Liu T, Gao YJ, Ji RR (2012) Emerging role of Toll-like receptors in the control of pain and itch. Neurosci Bull 28:131–144

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Löscher W, Klitgaard H, Twyman RE, Schmidt D (2013) New avenues for anti-epileptic drug discovery and development. Nat Rev Drug Discov 12:757–776

    Article  PubMed  CAS  Google Scholar 

  • Luan H, Kan Z, Xu Y, Lv C, Jiang W (2013) Rosmarinic acid protects against experimental diabetes with cerebral ischemia: relation to inflammation response. J Neuroinflammation 17:10–28

    Google Scholar 

  • Lucarini R, Bernardes WA, Ferreira DS, Tozatti MG, Furtado R, Bastao JK, Pauletti PM, Januário AH, Silva ML, Cunha WR (2013) In vivo analgesic and anti-inflammatory activities of Rosmarinus officinalis aqueous extract, rosmarinic acid and its acetyl ester derivative. Pharm Biol 51:1087–1090

    Article  CAS  PubMed  Google Scholar 

  • Lucassen PJ, Fuchs E, Czéh B (2004) Antidepressant treatment with tianeptine reduces apoptosis in the hippocampal dentate gyrus and temporal cortex. Biol Psychiatry 55:789–796

  • Luft JG, Steffens L, Morás AM, da Rosa MS, Leipnitz G, Regner GG, Pflüger PF, Gonçalves D, Moura DJ, Pereira P (2019) Rosmarinic acid improves oxidative stress parameters and mitochondrial respiratory chain activity following 4-aminopyridine and picrotoxin-induced seizure in mice. Naunyn Schmiedeberg's Arch Pharmacol 392:1347–1358

    Article  CAS  Google Scholar 

  • Maccioni RB, Munoz JP, Barbeito L (2001) The molecular bases of Alzheimer’s disease and other neurodegenerative disorders. Arch Med Res 32:367–381

    Article  CAS  PubMed  Google Scholar 

  • Malberg JE, Eisch AJ, Nestler EJ, Duman RS (2000) Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. J Neurosci 20:9104–9110

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Manchope MF, Calixto-Campos C, Coelho-Silva L, Zarpelon AC, Pinho-Ribeiro FA, Georgetti SR, Baracat MM, Casagrande R, Verri WA Jr (2016) Naringenin inhibits superoxide anion-induced inflammatory pain: role of oxidative stress, cytokines, Nrf-2 and the NO-cGMP-PKG-KATP channel signaling pathway. PLoS One 5(11):e0153015

    Article  CAS  Google Scholar 

  • Martinc B, Grabnar I, Vovk T (2014) Antioxidants as a preventive treatment for epileptic process: a review of the current status. Curr Neuropharmacol 12:527–550

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Mehler MF, Gokhan S (2000) Mechanisms underlying neural cell death in neurodegenerative diseases: alterations of a developmentally mediated cellular rheostat. Trends Neurosci 23:599–605

    Article  CAS  PubMed  Google Scholar 

  • Minghetti L (2007) Role of COX-2 in inflammatory and degenerative brain diseases. Subcell Biochem 42:127–141

    Article  PubMed  Google Scholar 

  • Mohr A, Zwacka RM (2007) In situ trapping of initiator caspases reveals intermediate surprises. Cell Biol Int 31:526–530

    Article  CAS  PubMed  Google Scholar 

  • Monk PN, Shaw PJ (2006) ALS: life and death in a bad neighborhood. Nat Med 12:885–887

    Article  CAS  PubMed  Google Scholar 

  • Montine TJ, Sidell KR, Crews BC, Markesbery WR, Marnett LJ, Roberts LJ 2nd, Morrow JD (1999) Elevated CSF prostaglandin E2 levels in patients with probable AD. Neurology 53:1495–1498

    Article  CAS  PubMed  Google Scholar 

  • Nie H, Peng Z, Lao N, Wang H, Chen Y, Fang Z, Hou W, Gao F, Li X, Xiong L, Tan Q (2014) Rosmarinic acid ameliorates PTSD-like symptoms in a rat model and promotes cell proliferation in the hippocampus. Prog Neuro-Psychopharmacol Biol Psychiatry 51:16–22

    Article  CAS  Google Scholar 

  • Nunes S, Madureira AR, Campos D, Sarmento B, Gomes AM, Pintado M, Reis F (2017) Therapeutic and nutraceutical potential of rosmarinic acid-Cytoprotective properties and pharmacokinetic profile. Crit Rev Food Sci Nutr 57:1799–1806

    CAS  PubMed  Google Scholar 

  • Obrosova IG (2003) Update on the pathogenesis of diabetic neuropathy. Curr Diab Rep 3:439–445

    Article  PubMed  Google Scholar 

  • Ohnishi M, Morishita H, Iwahashi H, Toda S, Shirataki Y, Kimura M, Kido R (1993) Inhibitory effects of chlorogenic acids on linoleic acid peroxidation and haemolysis. Phytochemistry 36:579–583

    Article  Google Scholar 

  • Old EA, Clark AK, Malcangio M (2015) The role of glia in the spinal cord in neuropathic and inflammatory pain. Handb Exp Pharmacol 227:145–170

    Article  PubMed  Google Scholar 

  • Ono K, Yamada M (2006) Antioxidant compounds have potent anti-fibrillogenic and fibril-destabilizing effects for a-synuclein fibrils in vitro. J Neurochem 97:105–115

    Article  CAS  PubMed  Google Scholar 

  • Ono K, Yamada M (2011) Low-n oligomers as therapeutic targets of Alzheimer disease. J Neurochem 117:19–28

    Article  CAS  PubMed  Google Scholar 

  • Ono K, Hasegawa K, Naiki H, Yamada M (2004) Curcumin has potent anti-amyloidogenic effects for Alzheimer-amyloid fibrils in vitro. Neurosci Res 75:742–750

    Article  CAS  Google Scholar 

  • Ono K, Li L, Takamura Y, Yoshiike Y, Zhu L, Han F, Mao X, Ikeda T, Takasaki J, Nishijo H, Takashima A, Teplow DB, Zagorski MG, Yamada M (2012) Phenolic compounds prevent amyloid β-protein oligomerization and synaptic dysfunction by site-specific binding. J Biol Chem 287:14631–14643

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Onyango IG (2008) Mitochondrial dysfunction and oxidative stress in Parkinson’s disease. Neurochem Res 33:589–597

    Article  CAS  PubMed  Google Scholar 

  • Page-McCaw A, Ewald AJ, Werb Z (2007) Matrix metalloproteinases and the regulation of tissue remodeling. Nat Rev Mol Cell Biol 8:221–233

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Pavese N, Andrews TC, Brooks DJ, Ho AK, Rosser AE, Barker RA, Robbins TW, Sahakian BJ, Dunnett SB, Piccini P (2003) Progressive striatal and cortical dopamine receptor dysfunction in Huntington’s disease: a PET study. Brain 126:1127–1135

    Article  PubMed  Google Scholar 

  • Pereira P, Tysca D, Oliveira P, da Silva Brum LF, Picada JN, Ardenghi P (2005) Neurobehavioral and genotoxic aspects of rosmarinic acid. Pharmacol Res 52:199–203

    Article  CAS  PubMed  Google Scholar 

  • Pereira P, Oliveira PA, Ardenghi P, Rotta L, Henriques JA, Picada JN (2006) Neuropharmacological analysis of caffeic acid in rats. Basic Clin Pharmacol Toxicol 99:374–378

    Article  CAS  PubMed  Google Scholar 

  • Petersen M, Simmonds MS (2003) Rosmarinic acid. Phytochemistry 62:121–125

    Article  CAS  PubMed  Google Scholar 

  • Pietsch K, Saul N, Chakrabarti S, Sturzenbaum SR, Menzel R, Steinberg CE (2011) Hormetins, antioxidants and prooxidants: defining quercetin-, caffeic acid- and rosmarinic acid-mediated life extension in C. elegans. Biogerontology 12:329–347

    Article  CAS  PubMed  Google Scholar 

  • Price DL, Sisodia SS, Borchelt DR (1998) Genetic neurodegenerative diseases: the human illness and transgenic models. Science 282:1079–1083

    Article  CAS  PubMed  Google Scholar 

  • Qiao S, Li W, Tsubouchi R, Haneda M, Murakami K, Takeuchi F, Nisimoto Y, Yoshino M (2005) Rosmarinic acid inhibits the formation of reactive oxygen and nitrogen species in RAW264.7 macrophages. Free Radic Res 39:995–1003

    Article  CAS  PubMed  Google Scholar 

  • Rahbardar MG, Amin B, Mehri S, Mirnajafi-Zadeh SJ, Hosseinzadeh H (2018) Rosmarinic acid attenuates development and existing pain in a rat model of neuropathic pain: an evidence of anti-oxidative and anti-inflammatory effects. Phytomedicine 40:59–67

    Article  CAS  PubMed  Google Scholar 

  • Re F, Cambianica I, Sesana S, Salvati E, Cagnotto A, Salmona M, Couraud PO, Moghimi SM, Masserini M, Sancini G (2010) Functionalization with ApoEderived peptides enhances the interaction with brain capillary endothelial cells of nanoliposomes binding amyloid-beta peptide. J Biotechnol 156:341–346

    Article  CAS  Google Scholar 

  • Ren P, Jiang H, Li R, Wang J, Song N, Xu HM, Xie JX (2009) Rosmarinic acid inhibits 6-OHDA-induced neurotoxicity by anti-oxidation in MES23.5 cells. J Mol Neurosci 39:220–225

    Article  CAS  PubMed  Google Scholar 

  • Rezaei M, Rasekh HR, Ahmadiani A, Pourahmad J (2008) Involvement of subcellular organelles in inflammatory pain-induced oxidative stress and apoptosis in the rat hepatocytes. Arch Iran Med 11:407–417

    CAS  PubMed  Google Scholar 

  • Ritzel RM, Crapser J, Patel AR, Verma R, Grenier JM, Chauhan A, Jellison ER, McCullough LD (2016) Age-associated resident memory CD8 T cells in the central nervous system are primed to potentiate inflammation after ischemic brain injury. J Immunol 196:3318–3330

    Article  CAS  PubMed  Google Scholar 

  • Rizk HA, Masoud MA, Maher OW (2017) Prophylactic effects of ellagic acid and rosmarinic acid on doxorubicin-induced neurotoxicity in rats. J Biochem Mol Toxicol 31:12

    Article  CAS  Google Scholar 

  • Rocha J, Eduardo-Figueira M, Barateiro A, Fernandes A, Brites D, Bronze R, Duarte CM, Serra AT, Pinto R, Freitas M, Fernandes E, Silva-Lima B, Mota-Filipe H, Sepodes B (2015) Anti-inflammatory effect of rosmarinic acid and an extract of Rosmarinus officinalis in rat models of local and systemic inflammation. Basic Clin Pharmacol Toxicol 116:398–413

  • Roos RA (2010) Huntington’s disease: a clinical review. Orphanet J Rare Dis 5:40

  • Rosenbrock H, Koros E, Bloching A, Podhorna J, Borsini F (2005) Effect of chronic intermittent restraint stress on hippocampal expression of marker proteins for synaptic plasticity and progenitor cell proliferation in rats. Brain Res 1040:55–63

    Article  CAS  PubMed  Google Scholar 

  • Roychaudhuri R, Yang M, Hoshi MM, Teplow DB (2009) Amyloid protein assembly and Alzheimer disease. J Biol Chem 284:4749–4753

    Article  CAS  PubMed  Google Scholar 

  • Sacerdote P, Franchi S, Moretti S, Castelli M, Procacci P, Magnaghi V, Panerai AE (2013) Cytokine modulation is necessary for efficacious treatment of experimental neuropathic pain. J NeuroImmune Pharmacol 8:202–211

    Article  PubMed  Google Scholar 

  • Santarelli L, Saxe M, Gross C, Surget A, Battaglia F, Dulawa S, Weisstaub N, Lee J, Duman R, Arancio O, Belzung C, Hen R (2003) Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science 301:805–809

    Article  CAS  PubMed  Google Scholar 

  • Sasaki K, El Omri A, Kondo S, Han J, Isoda H (2013) Rosmarinus officinalis polyphenols produce anti-depressant like effect through monoaminergic and cholinergic functions modulation. Behav Brain Res 1:86–94

    Article  CAS  Google Scholar 

  • Sayre LM, Perry G, Smith MA (2008) Oxidative stress and neurotoxicity. Chem Res Toxicol 21:172–188

    Article  PubMed  Google Scholar 

  • Scarpati ML, Oriente G (1958) Isolamento e costituzione dell’acido rosmarinico (dal rosmarinus off.). Rice Sci 28:2329–2333

    CAS  Google Scholar 

  • Schuessel K, Schäfer S, Bayer TA, Czech C, Pradier L, Müller-Spahn F, Müller WE, Eckert A (2005) Impaired Cu/Zn-SOD activity contributes to increased oxidative damage in APP transgenic mice. Neurobiol Dis 18:89–99

    Article  CAS  PubMed  Google Scholar 

  • Sepand MR, Soodi M, Hajimehdipoor H, Soleimani M, Sahraei E (2013) Comparison of neuroprotective effects of Melissa officinalis total extract and its acidic and non-acidic fractions against a β-induced toxicity. Iran J Pharm Res 12:415–423

    PubMed  PubMed Central  Google Scholar 

  • Shan Y, Wang DD, Xu YX, Wang C, Cao L, Liu YS, Zhu CQ (2016) Aging as a precipitating factor in chronic restraint stress-induced tau aggregation pathology, and the protective effects of rosmarinic acid. J Alzheimers Dis 49:829–844

    Article  CAS  PubMed  Google Scholar 

  • Shang AJ, Yang Y, Wang HY, Tao BZ, Wang J, Wang ZF, Zhou DB (2016) Spinal cord injury effectively ameliorated by neuroprotective effects of rosmarinic acid. Nutr Neurosci 20:172–179

    Article  PubMed  CAS  Google Scholar 

  • Shankar GM, Li S, Mehta TH, Garcia-Munoz A, Shepardson NE, Smith I, Brett FM, Farrell MA, Rowan MJ, Lemere CA, Regan CM, Walsh DM, Sabatini BL, Selkoe DJ (2008) Amyloid-βprotein dimers isolated directly from Alzheimer brains impair synaptic plasticity and memory. Nat Med 14:837–842

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Shimojo Y, Kosaka K, Noda Y, Shimizu T, Shirasawa T (2010) Effect of rosmarinic acid in motor dysfunction and life span in a mouse model of familial amyotrophic lateral sclerosis. Neurosci Res 88:896–904

    CAS  Google Scholar 

  • Smith CD, Carney JM, Starke-Reed PE, Oliver CN, Stadtman ER, Floyd RA, Markesbery WR (1991) Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease. Proc Natl Acad Sci U S A 88:10540–10543

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sueishi Y, Hori M, Ishikawa M, Matsu-Ura K, Kamogawa E, Honda Y, Kita M, Ohara K (2014) Scavenging rate constants of hydrophilic antioxidants against multiple reactive oxygen species. J Clin Biochem Nutr 54:67–74

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Szwajgier D (2015) Anticholinesterase activity of selected phenolic acids and flavonoids – interaction testing in model solutions. Ann Agric Environ Med 22:690–694

    Article  CAS  PubMed  Google Scholar 

  • Takahashi R, Ono K, Takamura Y, Mizuguchi M, Ikeda T, Nishijo H, Yamada M (2015) Phenolic compounds prevent the oligomerization of a-synuclein and reduce synaptic toxicity. J Neurochem 134:943–955

    Article  CAS  PubMed  Google Scholar 

  • Takeda H, Tsuji M, Inazu M, Egashira T, Matsumiya T (2002b) Rosmarinic acid and caffeic acid produce antidepressive-like effect in the forced swimming test in mice. Eur J Pharmacol 449:261–267

    Article  CAS  PubMed  Google Scholar 

  • Takeda H, Tsuji M, Matsumiya T, Kubo M (2002a) Identification of rosmarinic acid as a novel antidepressive substance in the leaves of Perilla frutescens Britton var. acuta Kudo (Perillae Herba). Nihon Shinkei Seishin Yakurigaku Zasshi 22:15–22

    CAS  PubMed  Google Scholar 

  • Takeda H, Tsuji M, Miyamoto J, Masuya J, Iimori M, Matsumiya T (2003) Caffeic acid produces antidepressive- and/or anxiolytic-like effects through indirect modulation of the alpha 1A-adrenoceptor system in mice. Neuroreport 14:1067–1070

    CAS  PubMed  Google Scholar 

  • Takeda H, Tsuji M, Yamada T, Masuya J, Matsushita K, Tahara M, Iimori M, Matsumiya T (2006) Caffeic acid attenuates the decrease in cortical BDNF mRNA expression induced by exposure to forced swimming stress in mice. Eur J Pharmacol 534:115–121

    Article  CAS  PubMed  Google Scholar 

  • Tanapat P, Galea LA, Gould E (1998) Stress inhibits the proliferation of granule cell precursors in the developing dentate gyrus. Int J Dev Neurosci 16:235–239

    Article  CAS  PubMed  Google Scholar 

  • Taylor RC, Cullen SP, Martin SJ (2008) Apoptosis: controlled demolition at the cellular level. Nat Rev Mol Cell Biol 9:231–241

    Article  CAS  PubMed  Google Scholar 

  • Teunissen CE, Steinbusch HW, Angevaren M, Appels M, de Bruijn C, Prickaerts J, de Vente J (2001) Behavioural correlates of striatal glial fibrillary acidic protein in the 3-nitropropionic acid rat model: disturbed walking pattern and spatial orientation. Neuroscience 105:153–167

    Article  CAS  PubMed  Google Scholar 

  • Treede RD, Jensen TS, Campbell JN, Cruccu G, Dostrovsky JO, Griffin JW, Hansson P, Hughes R, Nurmikko T, Serra J (2008) Neuropathic pain redefinition and a grading system for clinical and research purposes. Neurology 70:1630–1635

    Article  CAS  PubMed  Google Scholar 

  • Valsecchi AE, Franchi S, Panerai AE, Rossi A, Sacerdote P, Colleoni M (2011) The soy isoflavone genistein reverses oxidative and inflammatory state neuropathic pain, neurotrophic and vasculature deficits in diabetes mouse model. Eur J Pharmacol 650:694–702

    Article  CAS  PubMed  Google Scholar 

  • van Rooy I, Mastrobattista E, Storm G, Hennink WE, Schiffelers RM (2011) Comparison of five different targeting ligands to enhance accumulation of liposomes into the brain. J Control Release 150:30–36

    Article  PubMed  CAS  Google Scholar 

  • Vanegas H, Schaible HG (2001) Prostaglandins and cycloxygenases in the spinal cord. Prog Neurobiol 64:327–363

    Article  CAS  PubMed  Google Scholar 

  • Vasko MR, Campbell WB, Waite KJ (1994) Prostaglandin E2 enhances bradykinin stimulated release of neuropeptides from rat sensory neurons in culture. J Neurosci 14:4987–4997

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wagner S, Zensi A, Wien SL, Tschickardt SE, Maier W, Vogel T, Worek F, Pietrzik CU, Kreuter J, von Briesen H (2012) Uptake mechanism of ApoE modified nanoparticles on brain capillary endothelial cells as a blood–brain barrier model. PLoS One 7:e32568

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wang J, Xu H, Jiang H, Du X, Sun P, Xie J (2012) Neurorescue effect of rosmarinic acid on 6-hydroxydopamine-lesioned nigral dopamine neurons in rat model of Parkinson’s disease. J Mol Neurosci 47:113–119

    Article  CAS  PubMed  Google Scholar 

  • Wang P, Xue Y, Shang X, Liu Y (2010) Diphtheria toxin mutant CRM197-mediated transcytosis across blood–brain barrier in vitro. Cell Mol Neurobiol 30:717–725

    Article  CAS  PubMed  Google Scholar 

  • Whitehouse PJ, Price DL, Clark AW, Coyle JT, DeLong MR (1982) Alzheimer’s disease: evidence for selective loss of cholinergic neurons in the nucleus basalis. Ann Neurol 215:1237–1239

    CAS  Google Scholar 

  • Woolf CJ (2010) What is this thing called pain? J Clin Invest 120:3742–3744

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wu Z, Xu Q, Zhang L, Kong D, Ma R, Wang L (2009) Protective effect of resveratrol against kainate-induced temporal lobe epilepsy in rats. Neurochem Res 34:1393–1400

    Article  CAS  PubMed  Google Scholar 

  • Yang J, Hou C, Ma N, Liu J, Zhang Y, Zhou J, Xu L, Li L (2007) Enriched environment treatment restores impaired hippocampal synaptic plasticity and cognitive deficits induced by prenatal chronic stress. Neurobiol Learn Mem 87:257–263

    Article  PubMed  Google Scholar 

  • Yiangou Y, Facer P, Durrenberger P, Chessell IP, Naylor A, Bountra C, Banati RR, Anand P (2006) COX-2, CB2 and P2X7-immunoreactivities are increased in activated microglial cells/macrophages of multiple sclerosis and amyotrophic lateral sclerosis spinal cord. BMC Neurol 6:12

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Zecca L, Youdim MB, Riederer P, Connor JR, Crichton RR (2004) Iron, brain ageing and neurodegenerative disorders. Nat Rev Neurosci 5:863–873

    Article  CAS  PubMed  Google Scholar 

  • Zhang M, Yan H, Li S, Yang J (2016) Rosmarinic acid protects rat hippocampal neurons from cerebral ischemia/reperfusion injury via the Akt/JNK3/caspase-3 signaling pathway. Brain Res 1657:9–15

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran

    Mahboobeh Ghasemzadeh Rahbardar & Hossein Hosseinzadeh

  2. Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran

    Hossein Hosseinzadeh

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  1. Mahboobeh Ghasemzadeh Rahbardar
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HH provided the overall concept and framework of the manuscript; MGR researched and identified appropriate articles, and wrote the manuscript; HH revised the manuscript; all authors approved the final version of the manuscript.

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Ghasemzadeh Rahbardar, M., Hosseinzadeh, H. Effects of rosmarinic acid on nervous system disorders: an updated review. Naunyn-Schmiedeberg's Arch Pharmacol 393, 1779–1795 (2020). https://doi.org/10.1007/s00210-020-01935-w

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