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Es kann die Spur von unseren Erdetagen—on pharmacologists and pharmacology

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Abstract

Es kann die Spur von unseren Erdetagen is a slightly modified line from Goethe’s tragedy Faust and together with the following line can be translated as “The vestiges of our path on earth/Through aeons cannot fade away”. The author’s festival speech at the 50th Spring Meeting of the German Pharmacological Society this year in Mainz was given under that title and is presented here in abridged form. Twelve examples are given showing that indeed our, the pharmacologists’, professional vestiges cannot disappear. Many pharmacologists may share this view of their profession.

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References

  • Chang MM, Leeman SE, Niall HD (1971) Amino-acid sequence of substance P. Nat New Biol 232:86–87

    Article  CAS  PubMed  Google Scholar 

  • Donnerer J, Lembeck F (2006) The chemical languages of the nervous system. Karger, Basel

    Google Scholar 

  • Eichelbaum M, Schwab M (2009) Wirkungen des Organismus auf Pharmaka: allgemeine Pharmakokinetik. In: Aktories K, Förstermann U, Hofmann F, Starke K (eds) Allgemeine und spezielle Pharmakologie und Toxikologie, 10th edn. Urban & Fischer, München, pp 36–64

    Google Scholar 

  • Eichelbaum M, Spannbrucker N, Dengler HJ (1975) N-Oxidation of sparteine in man and its interindividual differences. Naunyn Schmiedebergs Arch Pharmacol 287:R94

    Google Scholar 

  • Eichelbaum M, Spannbrucker N, Steincke B, Dengler HJ (1979) Defective N-Oxidation of sparteine in man: a new pharmacogenetic defect. Eur J Clin Pharmacol 16:183–187

    Article  CAS  PubMed  Google Scholar 

  • Faust ES (1900) Ueber die Ursachen der Gewöhnung an Morphin. Arch Exp Pathol Pharmakol 44:217–238

    Article  Google Scholar 

  • Gilsbach R, Hein L (2008) Presynaptic metabotropic receptors for acetylcholine and adrenaline/noradrenaline. In: Südhof TC, Starke K (eds) Pharmacology of neurotransmitter release. Handbook of experimental pharmacology, vol 184. Springer, Berlin, pp 261–288

    Chapter  Google Scholar 

  • Habermann E, Dreyer F, Bigalke H (1980) Tetanus toxin blocks the neuromuscular transmission in vitro like botulinum A toxin. Naunyn Schmiedebergs Arch Pharmacol 311:33–40

    Article  CAS  PubMed  Google Scholar 

  • Haycraft JB (1884) Ueber die Einwirkung eines Secretes des officinellen Blutegels auf die Gerinnbarkeit des Blutes. Arch Exp Pathol Pharmakol 18:209–217

    Article  Google Scholar 

  • Hertting G, Schiefthaler T (1963) Beziehung zwischen Durchflußgröße und Noradrenalinfreisetzung bei Nervenreizung der isoliert durchströmten Katzenmilz. Naunyn-Schmiedebergs Arch Exp Pathol Pharmakol 246:13–14

    CAS  Google Scholar 

  • Jacobj C (1904) Ueber Hirudin. Dtsch Med Wochenschr 30:1786–1787

    Google Scholar 

  • Jakobs KH, Saur W, Schultz G (1978) Inhibition of platelet adenylate cyclase by epinephrine requires GTP. FEBS Lett 85:167–170

    Article  CAS  PubMed  Google Scholar 

  • Jakobs KH, Aktories K, Schultz G (1979) GTP-dependent inhibition of cardiac adenylate cyclase by muscarinic cholinergic agonists. Naunyn Schmiedebergs Arch Pharmacol 310:113–119

    Article  CAS  PubMed  Google Scholar 

  • Klavdieva MM (1996) The history of neuropeptides. Front Neuroendocrinol 17:126–153

    Article  CAS  PubMed  Google Scholar 

  • Leeman SE, Mroz EA (1974) Substance P. Life Sci 15:2033–2044

    Article  CAS  Google Scholar 

  • Lembeck F, Starke K (1968) Substanz P und Speichelsekretion. Naunyn-Schmiedebergs Arch Pharmakol Exp Pathol 259:375–385

    Article  CAS  Google Scholar 

  • Lindner E, Dohadwalla AN, Bhattacharya BK (1978) Positive inotropic and blood pressure lowering activity of a diterpene derivative isolated from Coleus forskohlii: forskolin. Arzneim Forsch 28:284–289

    CAS  Google Scholar 

  • Löffelholz K, Muscholl E (1969) A muscarinic inhibition of the noradrenaline release evoked by postganglionic sympathetic nerve stimulation. Naunyn-Schmiedebergs Arch Pharmakol 265:1–15

    Article  PubMed  Google Scholar 

  • Löffelholz K, Muscholl E (1970) Inhibition by parasympathetic nerve stimulation of the release of the adrenergic transmitter. Naunyn-Schmiedebergs Arch Pharmakol 267:181–184

    Article  PubMed  Google Scholar 

  • Lüllmann H, Mohr K, Hein L (2006) Pharmakologie und Toxikologie, 16th edn. Thieme, Stuttgart

    Google Scholar 

  • Markwardt F (1956) Untersuchungen über den Mechanismus der blutgerinnungshemmenden Wirkung des Hirudins. Naunyn-Schmiedebergs Arch Exp Pathol Pharmakol 229:389–399

    Article  CAS  PubMed  Google Scholar 

  • Metzger H, Lindner E (1981) The positive inotropic-acting forskolin, a potent adenylatecyclase activator. Arzneim Forsch 31:1248–1250

    CAS  Google Scholar 

  • Nowak G, Schrör K (2007) Hirudin—the long and stony way from an anticoagulant peptide in the saliva of medicinal leech to a recombinant drug and beyond. Thromb Haemost 98:116–119

    CAS  PubMed  Google Scholar 

  • Otsuka M, Yoshioka K (1993) Transmitter functions of tachykinins. Physiol Rev 73:229–308

    CAS  PubMed  Google Scholar 

  • Remmer H (1972) Induction of drug metabolizing enzyme system in the liver. Eur J Clin Pharmacol 5:116–136

    Article  CAS  Google Scholar 

  • Remmer H, Merker HJ (1963) Enzyminduktion und Vermehrung von endoplasmatischem Reticulum in der Leberzelle während der Behandlung mit Phenobarbital (Luminal). Klin Wochenschr 41:276–283

    Article  CAS  PubMed  Google Scholar 

  • Remmer H, Siegert M, Merker HJ (1963) Beschleunigung des Arzneimittelstoffwechsels durch Enzyminduktion. Naunyn-Schmiedebergs Arch Exp Pathol Pharmakol 246:58–59

    CAS  Google Scholar 

  • Repke K, Klesczewski S, Roth L (1959) Über Spaltung und Hydroxylierung von Digitoxin bei der Ratte. Naunyn-Schmiedebergs Arch Exp Pathol Pharmakol 237:34–48

    CAS  PubMed  Google Scholar 

  • Rossetto O, Montecucco C (2008) Presynaptic neurotoxins with enzymatic activities. In: Südhof TC, Starke K (eds) Pharmacology of neurotransmitter release. Handbook of experimental pharmacology, vol 184. Springer, Berlin, pp 129–170

    Chapter  Google Scholar 

  • Sanders D, Habermann E (1992) Evidence for a link between specific proteolysis and inhibition of [3H]-noradrenaline release by the light chain of tetanus toxin. Naunyn Schmiedebergs Arch Pharmacol 346:358–361

    Article  CAS  PubMed  Google Scholar 

  • Starke K (2009) Pharmakologie noradrenerger und adrenerger Systeme. In: Aktories K, Förstermann U, Hofmann F, Starke K (eds) Allgemeine und spezielle Pharmakologie und Toxikologie, 10th edn. Urban & Fischer, München, pp 161–199

    Google Scholar 

  • Starling EH (1907) Die chemische Koordination der Körpertätigkeiten. Verhandlungen der Gesellschaft deutscher Naturforscher und Ärzte, 78. Versammlung. Vogel, Leipzig, pp 246–260

    Google Scholar 

  • Ther L, Muschaweck R, Hergott J (1957) Antagonismus zwischen Adenosin und Methyl-Xanthinen am Reizleitungssystem des Herzens. Naunyn-Schmiedebergs Arch Exp Pathol Pharmakol 231:586–590

    Article  CAS  PubMed  Google Scholar 

  • Trendelenburg U (1960) The action of histamine and 5-hydroxytryptamine on isolated mammalian atria. J Pharmacol Exp Ther 130:450–460

    CAS  PubMed  Google Scholar 

  • Trendelenburg AU, Meyer A, Wess J, Starke K (2005) Distinct mixtures of muscarinic receptor subtypes mediate inhibition of noradrenaline release in different mouse peripheral tissues, as studied with receptor knockout mice. Br J Pharmacol 145:1153–1159

    Article  CAS  PubMed  Google Scholar 

  • Wallis RB (1988) Hirudins and the role of thrombin: lessons from leeches. TIPS 9:425–427

    CAS  PubMed  Google Scholar 

Download references

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  1. Institut für Experimentelle und Klinische Pharmakologie und Toxikologie, Albertstraße 25, 79104, Freiburg im Breisgau, Germany

    Klaus Starke

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  1. Klaus Starke
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Correspondence to Klaus Starke.

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Starke, K. Es kann die Spur von unseren Erdetagen—on pharmacologists and pharmacology. Naunyn-Schmied Arch Pharmacol 380, 465–471 (2009). https://doi.org/10.1007/s00210-009-0443-7

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  • DOI: https://doi.org/10.1007/s00210-009-0443-7

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