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Age trends in proximal femur geometry in men: variation by race and ethnicity

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Abstract

Summary

Data on bone architecture in diverse male populations are limited. We examined proximal femur geometry in 1,190 black, Hispanic, and white men. Cross-sectional analyses indicate greatest bone strength among black men, and greater age-related differences in bone strength among Hispanic men than other subjects at the narrow neck and intertrochanter regions of the proximal femur.

Introduction

Although race/ethnic differences in bone mass are well-documented, less is known about differences in bone architecture. We examined proximal femur geometry in a diverse, randomly-sampled population of 1,190 community-dwelling men (age 30–79 y).

Methods

Dual X-ray absorptiometry scans were obtained for 355 black, 394 Hispanic, and 441 white subjects. Measures were obtained for the narrow neck (NN), intertrochanter (IT) and shaft regions of the proximal femur via hip structural analysis. Analyses considered bone mineral density (BMD, g/cm2), outer diameter (cm), cross-sectional area (CSA, cm2), section modulus (Z, cm3), and buckling ratio (BR). Results were adjusted for height, weight and physical activity level.

Results

Black subjects exhibited greater age-specific BMD, CSA and Z, than their white counterparts. For instance, at age 50 y, NN BMD was approximately 11% higher among black men (p < 0.001). Hispanic men exhibited sharper age-related differences in NN and IT BMD than did others. IT BMD, for instance, decreased by 2.4% with 10 y age among Hispanic subjects, but had virtually no age trend in others (p < 0.001).

Conclusions

These results imply greater bone strength among black American men than among their white counterparts, and may indicate elevated fracture risk among older Hispanic American subpopulations.

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Acknowledgement

The BACH/Bone study was supported by grant AG 20727 from the National Institute on Aging (NIA). The parent study (BACH) was supported by grant DK 56842 from the National Institute of Diabetes and Digestive and Kidney Diseases.

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Authors and Affiliations

  1. New England Research Institutes, 9 Galen Street, Watertown, MA, 02472, USA

    T. G. Travison, G. R. Esche, A. B. Araujo & J. B. McKinlay

  2. Johns Hopkins University School of Medicine, Baltimore, MD, USA

    T. J. Beck

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  1. T. G. Travison
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  2. T. J. Beck
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  3. G. R. Esche
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  4. A. B. Araujo
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  5. J. B. McKinlay
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Corresponding author

Correspondence to T. G. Travison.

Additional information

Grant support: The BACH/Bone study was supported by grant AG 20727 from the National Institute on Aging (NIA). The parent study (BACH) was supported by grant DK 56842 from the National Institute of Diabetes and Digestive and Kidney Diseases.

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Travison, T.G., Beck, T.J., Esche, G.R. et al. Age trends in proximal femur geometry in men: variation by race and ethnicity. Osteoporos Int 19, 277–287 (2008). https://doi.org/10.1007/s00198-007-0497-7

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  • DOI: https://doi.org/10.1007/s00198-007-0497-7

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