Abstract
High-resolution magnetic resonance imaging (hrMRI) has recently made it possible to evaluate trabecular bone structure in vivo. Despite obvious gender differences in fracture incidence at the distal radius, little is known about gender differences in trabecular bone microarchitecture and its relationship to the structural strength of the forearm. The aim of this study was to determine trabecular bone structure in the distal radius of elderly women and men and its correlation with failure loads of the distal radius as determined in a fall configuration. Specifically, we tested the hypotheses that structural indices differ between women and men and that they offer information that is independent from BMD for predicting structural strength. Intact right arms were obtained from 73 formalin-fixed cadavers (age 80±11 years, 43 women, 30 men). Trabecular structural indices (apparent bone volume fraction [app. BV/TV], trabecular number [app. Tb.N], trabecular separation [app. Tb.Sp], trabecular thickness [app. Tb.Th] and fractal dimension [Frac.Dim]) were assessed in the distal metaphysis, using hrMRI with 156 µm in-plane resolution and proprietary digital image analysis, while BMD was measured with dual X-ray absorptiometry (DXA). Women displayed significantly lower BMD (−29.8%, p <0.001), app. BV/TV (−8.2%, p <0.05) and app. Tb.Th (−10.2%, p <0.001) than men, whereas app. Tb.N, app. Tb.Sp. and fractal dimension did not differ significantly. Structural parameters differed between normal and osteopenic women (BV/TV: −11%, p <0.01; Tb.Th: −8%, p <0.001) and between normal and osteoporotic women BV/TV: −21%, p <0.001; Tb.Th: −16%, p <0.001). App. BV/TV, app. Tb.Th and fractal dimension provided information independent from BMD in the prediction of radial failure loads in multiple regression models. These findings imply that it should be of clinical interest to monitor both bone mass and trabecular microstructure for predicting osteoporotic fracture risk.
Similar content being viewed by others
References
Jensen GF, Christiansen C, Boesen J, Hegedus V, Transbol I (1982) Epidemiology of postmenopausal spinal and long bone fractures. A unifying approach to postmenopausal osteoporosis. Clin Orthop 166:75–81
Owen RA, Melton LJ III, Johnson KA, Ilstrup DM, Riggs BL (1982) Incidence of Colles’ fracture in a North American community. Am J Public Health 72:605–607
Cuddihy MT, Gabriel SE, Crowson CS, O’Fallon WM, Melton LJ III (1999) Forearm fractures as predictors of subsequent osteoporotic fractures. Osteoporos Int 9:469–475
Spadaro JA, Werner FW, Brenner RA, Fortino MD, Fay LA, Edwards WT (1994) Cortical and trabecular bone contribute strength to the osteopenic distal radius. J Orthop Res 12:211–218
Augat P, Iida H, Jiang Y, Diao E, Genant HK (1998) Distal radius fractures: mechanisms of injury and strength prediction by bone mineral assessment. J Orthop Res 16:629–635
Gordon CL, Webber CE, Nicholson PS (1998) Relation between image-based assessment of distal radius trabecular structure and compressive strength. Can Assoc Radiol J 49:390–397
Wigderowitz CA, Paterson CR, Dashti H, McGurty D, Rowley DI (2000) Prediction of bone strength from cancellous structure of the distal radius: can we improve on DXA? Osteoporos Int 11:840–846
Wu C, Hans D, He Y, Fan B, Njeh CF, Augat P, Richards J, Genant HK (2000) Prediction of bone strength of distal forearm using radius bone mineral density and phalangeal speed of sound. Bone 26:529–533
Lochmüller EM, Lill CA, Kuhn V, Schneider E, Eckstein F (2002) Radius bone strength in bending, compression, and falling and its correlation with clinical densitometry at multiple sites. J Bone Miner Res 17:1629–1638
Hudelmaier M, Kuhn V, Lochmuller EM, Well H, Priemel M, Link TM, Eckstein F (2004) Can geometry-based parameters from pQCT and material parameters from quantitative ultrasound (QUS) improve the prediction of radial bone strength over that by bone mass (DXA)? Osteoporos Int 15:375–381
Muller ME, Webber CE, Bouxsein ML (2003) Predicting the failure load of the distal radius. Osteoporos Int 14:345–352
Ouyang X, Selby K, Lang P, Engelke K, Klifa C, Fan B, Zucconi F, Hottya G, Chen M, Majumdar S, Genant HK (1997) High-resolution magnetic resonance imaging of the calcaneus: age-related changes in trabecular structure and comparison with dual X-ray absorptiometry measurements. Calcif Tissue Int 60:139–147
Link TM, Majumdar S, Grampp S, Guglielmi G, van Kuijk C, Imhof H, Glueer C, Adams JE (1999) Imaging of trabecular bone structure in osteoporosis. Eur Radiol 9:1781–1788
Majumdar S, Link TM, Augat P, Lin JC, Newitt D, Lane NE, Genant HK (1999) Trabecular bone architecture in the distal radius using magnetic resonance imaging in subjects with fractures of the proximal femur. Magnetic Resonance Science Center and Osteoporosis and Arthritis Research Group. Osteoporos Int 10:231–239
Newitt DC, Majumdar S, van RB, von IG, Harris ST, Genant HK, Chesnut C, Garnero P, MacDonald B (2002) In vivo assessment of architecture and micro-finite element analysis derived indices of mechanical properties of trabecular bone in the radius. Osteoporos Int 13:6–17
Laib A, Newitt DC, Lu Y, Majumdar S (2002) New model-independent measures of trabecular bone structure applied to in vivo high-resolution MR images. Osteoporos Int 13:130–136
Majumdar S, Newitt D, Mathur A, Osman D, Gies A, Chiu E, Lotz J, Kinney J, Genant H (1996) Magnetic resonance imaging of trabecular bone structure in the distal radius: relationship with X-ray tomographic microscopy and biomechanics. Osteoporos Int 6:376–385
Link TM, Vieth V, Langenberg R, Meier N, Lotter A, Newitt D, Majumdar S (2003) Structure analysis of high-resolution magnetic resonance imaging of the proximal femur: in vitro correlation with biomechanical strength and BMD. Calcif Tissue Int 72:156–165
Link TM, Majumdar S, Augat P, Lin JC, Newitt D, Lu Y, Lane NE, Genant HK (1998) In vivo high-resolution MRI of the calcaneus: differences in trabecular structure in osteoporosis patients. J Bone Miner Res 13:1175–1182
Jiang Y, Zhao J, Augat P, Ouyang X, Lu Y, Majumdar S, Genant HK (1998) Trabecular bone mineral and calculated structure of human bone specimens scanned by peripheral quantitative computed tomography: relation to biomechanical properties. J Bone Miner Res 13:1783–1790
Majumdar S, Kothari M, Augat P, Newitt DC, Link TM, Lin JC, Lang T, Lu Y, Genant HK (1998) High-resolution magnetic resonance imaging: three-dimensional trabecular bone architecture and biomechanical properties. Bone 22:445–454
Hwang SN, Wehrli FW, Williams JL (1997) Probability-based structural parameters from three-dimensional nuclear magnetic resonance images as predictors of trabecular bone strength. Med Phys 24:1255–1261
Melton LJ III (1995) Epidemiology of fractures. In: Riggs BL, Melton LJ (eds) Osteoporosis: Etiology, diagnosis and management, 2nd edn. Lippincott-Raven, Philadelphia, 225–249
Riggs BL, Melton LJ III (1995) The worldwide problem of osteoporosis: insights afforded by epidemiology. Bone 17:505–511
MacIntyre NJ, Adachi JD, Webber CE (1999) Gender differences in normal age-dependent patterns of radial bone structure and density: a cross-sectional study using peripheral quantitative computed tomography. J Clin Densitom 2:163–173
World Health Organization (1994) Definition of osteoporosis. Technical Report Series 843
Glüer CC, Blake G, Lu Y, Blunt BA, Jergas M, Genant HK (1995) Accurate assessment of precision errors: how to measure the reproducibility of bone densitometry techniques. Osteoporos Int 5:262–270
Newitt DC, Van Rietbergen B, Majumdar S (2002) Processing and analysis of in vivo high-resolution MR images of trabecular bone for longitudinal studies: reproducibility of structural measures and micro-finite element analysis derived mechanical properties. Osteoporos Int 13:278–287
Hayes WC, Bouxsein ML (1997) Biomechanics of cortical and trabecular bone: Implications for assessment of fracture risk. In: Mow VC, Hayes WC (eds) Basic orthopaedic biomechanics, 2nd edn. Lippincott-Raven, Philadelphia, pp 69–111
van der Meulen MC, Jepsen KJ, Mikic B (2001) Understanding bone strength: size isn’t everything. Bone 29:101–104
Muller ME, Webber CE, Bouxsein ML (2003) Predicting the failure load of the distal radius. Osteoporos Int 14:345–352
Lochmüller EM, Krefting N, Bürklein D, Eckstein F (2001) Effect of fixation, soft tissues, and scan projection on bone mineral measurements with dual energy X-ray absorptiometry (DXA). Calcif Tissue Int 68:140–145
Augat P, Reeb H, Claes LE (1996) Prediction of fracture load at different skeletal sites by geometric properties of the cortical shell. J Bone Miner Res 11:1356–1363
Edmondston SJ, Singer KP, Day RE, Breidahl PD, Price RI (1994) Formalin fixation effects on vertebral bone density and failure mechanics: an in vitro study of human and sheep vertebrae. Clin Biomech (Bristol Avon) 9:175–179
Grampp S, Genant HK, Mathur A, Lang P, Jergas M, Takada M, Glüer CC, Lu Y, Chavez M (1997) Comparisons of noninvasive bone mineral measurements in assessing age-related loss, fracture discrimination, and diagnostic classification. J Bone Miner Res 12:697–711
Myers ER, Sebeny EA, Hecker AT, Corcoran TA, Hipp JA, Greenspan SL, Hayes WC (1991) Correlations between photon absorption properties and failure load of the distal radius in vitro. Calcif Tissue Int 49:292–297
Njeh CF, Wu C, Fan B, Hans D, Fuerst T, He Y, Genant HK (2000) Estimation of wrist fracture load using phalangeal speed of sound: an in vitro study. Ultrasound Med Biol 26:1517–1523
Vieth V, Link TM, Lotter A, Persigehl T, Newitt D, Heindel W, Majumdar S (2001) Does the trabecular bone structure depicted by high-resolution MRI of the calcaneus reflect the true bone structure? Invest Radiol 36:210–217
Lin JC, Amling M, Newitt DC, Selby K, Srivastav SK, Delling G, Genant HK, Majumdar S (1998) Heterogeneity of trabecular bone structure in the calcaneus using magnetic resonance imaging. Osteoporos Int 8:16–24
Benhamou CL, Poupon S, Lespessailles E, Loiseau S, Jennane R, Siroux V, Ohley W, Pothuaud L (2001) Fractal analysis of radiographic trabecular bone texture and bone mineral density: two complementary parameters related to osteoporotic fractures. J Bone Miner Res 16:697–704
Acknowledgements
Gudrun Goldmann is to be thanked for her help with the DXA measurements, Harald Well for performing the mechanical test, and Dr. Stephan Metz for his help with obtaining the radiographs of the forearms after mechanical testing.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Hudelmaier, M., Kollstedt, A., Lochmüller, E.M. et al. Gender differences in trabecular bone architecture of the distal radius assessed with magnetic resonance imaging and implications for mechanical competence. Osteoporos Int 16, 1124–1133 (2005). https://doi.org/10.1007/s00198-004-1823-y
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00198-004-1823-y