Abstract
Background: More than 1.5 million fractures occur due to osteoporosis each year. This study examines the annual health care utilization and associated expenditures of osteoporotic patients who sustain a new fragility fracture and of those without a new fracture. Methods and procedures: The study sample from commercial claims databases consisted of patients enrolled in US plans between January 1, 1997, and December 31, 2001. Patients with both an osteoporosis diagnosis and a related fracture were classified as “osteoporosis with concurrent fracture”; all other osteoporosis patients were classified as “osteoporosis without concurrent fracture.” Annual utilization and expenditures for the concurrent-fracture cohort were compared with those without concurrent fracture, as well as with a group of patients without osteoporosis (controls) that was matched to the concurrent-fracture cohort based on age, gender, US region, health plan type, and length of enrollment. Exponential conditional mean models were used to compute regression-adjusted total expenditures across the groups. The differences in adjusted expenditures were used to generate the economic burden-of-illness estimates. Results: Osteoporosis patients with concurrent fracture incurred more than twice the overall health care expenditures in the study period, compared with those without fracture (US $15,942 vs $6,476), and nearly three times those of the control group (US $15,942 vs $4,658). Approximately 25% of the overall health care expenditures (US $4,014 of $15,942) for the concurrent-fracture group were osteoporosis-related expenditures, leading to the conclusion that comorbid conditions in osteoporosis patients with concurrent fracture contribute significantly to overall health care costs. Some of these comorbidity-related costs were likely due to pain-related disorders, which occurred significantly more frequently in the concurrent-fracture cohort than in the other groups. Conclusion: Osteoporosis-related expenditures, particularly those related to fracture, were substantial. However, non-osteoporosis-related expenditures to treat comorbid conditions constituted 75% of the overall health care costs in the year after an osteoporosis-related fracture, which warrants further investigation.
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References
World Health Organization (1994) Assessment of fracture risk and its application to screening for postmenopausal osteoporosis. WHO Technical Report Series, No. 843. WHO, Geneva
Buist DSM, LaCroix AZ, Manfredonia D, Abbott T (2002) Identifying postmenopausal women at high risk of fracture in populations: a comparison of three strategies. JAGS 50(6):1031–1038
Weber CE (1998) Uncertainties in bone mineral density T scores. Clin Invest Med 21(2):88–93
National Institute of Arthritis and Musculoskeletal and Skin Diseases (2000) Osteoporosis: progress and promise. National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD. http://www.niams.nih.gov/hi/topics/osteoporosis/opbkgr.htm. Cited 26 June 2003
National Institutes of Health (2000) Osteoporosis prevention, diagnosis, and therapy. NIH Consensus Statement. 17(1):1–45
Gehlbach SH, Bigelow C, Heimisdottir M, May S, Walker M, Kirkwood JR (2000) Recognition of Vertebral Fracture in a Clinical Setting. Osteoporos Int 11(7):577–582
Huang C, Ross PD, Wasnich RD (1996) Vertebral fracture and other predictors of physical impairment and health care utilization. Arch Intern Med 156(21):2469–2475
Nevitt MC, Ettinger B, Black DM, Stone K, Jamal SA, Ensrud K, Segal M, Genant HK, Cummings SR (1998) The association of radiographically detected vertebral fractures with back pain and function—a prospective study. Ann Intern Med 128(10):793–800
Lindsay R, Silverman SL, Cooper C, Hanley DA, Barton I, Broy SB, Licata A, Benhamou L, Geusens P, Flowers K, Stracke H, Seeman E (2001) Risk of new vertebral fracture in the year following a fracture. JAMA 285(3):320–323
Theodorou SJ, Theodorou DJ, Sartoris DJ (2003) Osteoporosis and fractures: the size of the problem. Hosp Med 64(2):87–91
Melton LJ, Gabriel SE, Crowson CS, Tosteson ANA, Johnell O, Kanis JA (2003) Cost-equivalence of different osteoporotic fractures. Osteoporos Int 14(5):383–388
Gabriel SE, Tosteson ANA, Leibson CL, Crowson CS, Pond GR, Hammond CS, Melton LJ (2002) Direct medical costs attributable to osteoporotic fractures. Osteoporos Int 13(4):323–330
Max W, Sinnot P, Kao C, Sung HY, Rice DP (2002) The burden of osteoporosis in California, 1998. Osteoporos Int 13(6):493–500
Berndt ER, A Bir, SH Busch, RG Frank, Normand SL (2002) The medical treatment of depression, 1991–1996: productive inefficiency, expected outcome variations, and price indexes. J Health Econ 21(3):373–396
Bridges CB, Thompson WW, Meltzer MI, Reeve G, Talamonti WJ, Cox NJ, Lilac HA, Hall H, Klimov A, Fukuda K (2000) Effectiveness and cost-benefit of influenza vaccination of healthy working adults: a randomized controlled trial. JAMA 284:1655–1663
Crown WH, Finkelstein S, Berndt ER, Ling D, Poret AW, Rush AJ, Russell JM (2002) The impact of treatment-resistant depression on health care utilization and costs. J Clin Psychol 63(11):963–971
Javitz H., Ward MM, Farber E, Nail L, Vallow SG (2002) The direct cost of care for psoriasis and psoriatic arthritis in the United States. J Am Acad Dermatol 46(6):850–860
D’Hoore W, Bouckaert A, Tilquin C (1996) Practical considerations on the use of the Charlson Comorbidity Index with administrative data bases. J Clin Epidemol 49(12):1429–1433
Manning WG, Newhouse JP, Duan N, Keeler EB, Leibowitz A, Marquis MS (1987) Health insurance and the demand for medical care: evidence from a randomized experiment. Am Econ Rev 77:251–277
Duan N, Manning W, Morris C, Newhouse J (1983) A comparison of alternative models for the demand for medical care. J Business Econ Stat 1(2):115–126
Cameron AC, Trivedi PK (1988). Regression analysis of count data. Cambridge University Press, Cambridge, MA
Zethraeus N, Ben Sedrine W, Caulin F, Corcaud S, Gathon HJ, Haim M, Johnell O, Jönsson B, Kanis JA, Tsouderos Y, Reginster JY (2002) Models for assessing the cost-effectiveness of the treatment and prevention of osteoporosis. Osteoporos Int 13:841–857
Johnell O (2003) Economic implication of osteoporotic spine disease: cost to society. Eur Spine J 12[Suppl 2]:S168–S169
Zethraeus N, Borgström F, Johnell O, Kanis J, Jönsson B (2002) Costs and quality of life associated with osteoporosis related fractures: results from a Swedish survey. Working Paper Series in Economics and Finance, No. 512. http://swopec.hhs.se/hastef/abs/hastef0512.htm. Cited 9 January 2004
Ray NF, Chan JK, Thamer M, Melton LJ (1997) Medical expenditures for the treatment of osteoporotic fractures in the United States in 1995: report from the National Osteoporosis Foundation. J Bone Miner Res 12:24–35
Hoerger TJ, Downs KE, Lakshmanan MC, Lindrooth RC, Plouffe L, Wendling B, West SL, Ohsfeldt RL (1999) Healthcare use among U.S. women aged 45 and older: total costs and costs for selected postmenopausal health risks. J Womens Health Gend Based Med 8(8):1077–1089
Burge RT, King AB, Balda E, Worley D (2003) Methodology for estimating current and future burden of osteoporosis in state populations: application to Florida in 2000 through 2025. Value Health 6(5):574–583
Jönsson B, Christiansen C, Johnell O, Hedbrandt J, Karlsson G (1996) Cost-effectiveness of fracture prevention in established osteoporosis. Scand J Rheumatol 103[Suppl]:30–38
Levy P, Levy E, Audran M, Cohen-Solal M, Fardellone P, Le Parc JM (2002). The cost of osteoporosis in men: the French situation. Bone 30(4):631–636
Ethgen O, Tellier V, Sedrine WB, DeMaesner J, Gosset C, Reginster JY (2003) Health Related Quality of Life and Cost of ambulatory Care in Osteoporosis: How may such outcome measures be valuable information to health decision makers and papers? Bone 32:718–724
Finnern HW, Sykes DP (2003) The hospital cost of vertebral fractures in the EU: estimates using national datasets. Osteoporos Int 14:429–436
De Laet C, Van Hout BA, Burger H, Weel A, Hofman A, Pols HA (1999) Incremental cost of medical care after hip fracture and first vertebral fracture: the Rotterdam Study. Osteoporos Int 10:66–72
Burge R, Puleo R, Gehlbach S, Worley D, Klar J (2002) Inpatient hospital and post-acute care for vertebral fractures in women. Value Health 5:301–311
Chrischilles E, Shireman T, Wallace R (1994) Costs and health effects of osteoporotic fractures. Bone 15:377–386
Alagiakrishnan K, Juby A, Hanley D, Tymchak W, Sclater A (2003) Role of vascular factors in osteoporosis. J Gerontol A Biol Sci Med Sci 58(4):362–366
Barengolts EI, Berman M, Kukreja SC, Kouznetsova T, Lin C, Chomka EV (1998) Osteoporosis and coronary atherosclerosis in asymptomatic postmenopausal women. Calcif Tissue Int 62:209–213
Hirose K, Tomiyama H, Okazaki R, Arai T, Koji Y, Zaydun G, Hori S, Yamashina A (2003) Increased pulse wave velocity associated with reduced calcaneal quantitative osteo-sono index: possible relationship between atherosclerosis and osteopenia. J Clin Endocrinol Metab 88:2573–2578
Brown SA, Sharpless JL (2004) Osteoporosis: an under-appreciated complication of diabetes. Clin Diabet 22:10–20
Jalava T, Sarna S, Pylkkanen L, Mawer B, Kanis JA, Selby P, Davies M, Adams J, Francis RM, Robinson J, McCloskey E (2003) Association between vertebral fracture and increased mortality in osteoporotic patients. J Bone Miner Res 18:1254–1260
Andrade SE, Majumdar SR, Chan KA, Buist DSM, Go AS, Goodman M, Smith DH, Platt R, Gurwitz JH (2003) Low frequency of treatment of osteoporosis among postmenopausal women following a fracture. Arch Intern Med 163:2052–2057
Gillepspy T, Gillespy MP (1991) Osteoporosis. Radiol Clin North Am 29:77–84
Kanis JA, Pitt FA (1992) Epidemiology of osteoporosis. Bone 13:S7–S15
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Funding: The authors gratefully acknowledge that funding for this analysis was provided by Eli Lilly and Company.
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Orsini, L.S., Rousculp, M.D., Long, S.R. et al. Health care utilization and expenditures in the United States: a study of osteoporosis-related fractures. Osteoporos Int 16, 359–371 (2005). https://doi.org/10.1007/s00198-004-1694-2
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DOI: https://doi.org/10.1007/s00198-004-1694-2