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Is the beneficial effect of antimuscarinics related to motor or sensory changes in the bladder?

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Abstract

Introduction and hypothesis

The aim of the study was to assess the sensory and motor effects of antimuscarinic treatment on the bladder in women with overactive bladder, detrusor overactivity demonstrated on urodynamics and a mean bladder wall thickness (BWT) greater than 5 mm.

Methods

Fifty-eight women underwent treatment with antimuscarinics in 12 weeks. Before treatment and at 1, 2, 6 and 12 weeks of treatment, women completed the patient perception of bladder condition (PPBC) single-item global questionnaire, indicated the severity of their urgency on a visual analogue scale (VAS) and underwent transvaginal ultrasound to determine mean bladder wall thickness (BWT).

Results

PPBC and VAS scores for urgency declined throughout the treatment course whereas mean BWT declined during the first 6 weeks of treatment and then reached a plateau after falling to below 5 mm.

Conclusion

The mechanism of action of antimuscarinics appears to be a complex interaction of sensory and motor components.

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Acknowledgments

We would like to express our gratitude for the support provided by the NIHR Biomedical Research Centre funding scheme.

Conflicts of interest

D. C. Panayi: funded by Pfizer for travel and accommodation -- International Continence Society Cairo 2008. V. Khullar: paid consultant to Astellas, Lilly, Allergan, Pfizer, Gynecare, Cook, Bioxell. R. Fernando: paid consultant to Astellas, Pfizer. P. Tekkis: no disclosures.

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Authors and Affiliations

  1. Imperial College Healthcare NHS Trust, South Kensington Campus, London, UK

    Demetri C. Panayi, Paris Tekkis, Ruwan Fernando & Vikram Khullar

  2. Department of Urogynaecology, St. Marys Hospital, Praed Street, London, W2 1NY, UK

    Demetri C. Panayi

Authors
  1. Demetri C. Panayi
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  2. Paris Tekkis
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  3. Ruwan Fernando
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  4. Vikram Khullar
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Correspondence to Demetri C. Panayi.

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Panayi, D.C., Tekkis, P., Fernando, R. et al. Is the beneficial effect of antimuscarinics related to motor or sensory changes in the bladder?. Int Urogynecol J 21, 841–845 (2010). https://doi.org/10.1007/s00192-010-1123-3

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  • DOI: https://doi.org/10.1007/s00192-010-1123-3

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