Skip to main content

Advertisement

Log in

Botox in urology

  • Review Article
  • Published:
International Urogynecology Journal Aims and scope Submit manuscript

Abstract

Lower urinary tract dysfunction is one of the challenging problems facing urologists and patients. Several treatment trials have been introduced in the literature, but none has proven to be as effective as being a gold standard treatment for such conditions. We reviewed the literature regarding the use of botulinum toxin (BTx) type A as a current treatment of lower urinary tract conditions described below. The toxin has been shown to be safe and effective in the treatment of conditions caused by increased muscle tonicity. Indications for the urological use of BTx and future applications are also considered.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

References

  1. Verhayden J, Blitzer A, Brin MF (2001) Other non cosmetic uses of Botox. Semin Cutan Med Surg 20(2):121–126

    Article  PubMed  Google Scholar 

  2. Neumann M, Wolfgang HJ, Toyka KV (1999) Botulinum toxin in the treatment of neurological disorders of the autonomic nervous system. Arch Neurol 56:914–916

    Article  PubMed  Google Scholar 

  3. Leippold T, Reitz A, Schurch B (2003) Botulinum toxin as a new therapy option for voiding disorders: current state of the art. Eur Urol 44:165–174

    Article  PubMed  CAS  Google Scholar 

  4. Divakara Kedlaya et al (2002) Botulinum toxin: overview. eMedicine (January 2002)

  5. www.bnf.org

  6. Schurch B (1998) Letters to the Editor—botulinum toxin in SCI. Arch Phys Med Rehabil 79:1481

    Article  PubMed  CAS  Google Scholar 

  7. Barnes M (2003) Botulinum toxin—mechanisms of action and clinical use in spasticity. J Rehab Med 41(Suppl):56–59

    Article  Google Scholar 

  8. Cannon TW, Chancellor MB (2002) Pharmacotherapy of the overactive bladder and advances in drug delivery. Clin Obstet Gynaecol 45(1):205–217

    Article  Google Scholar 

  9. Wheller JS Jr, Walter JS, Chintam RS et al (1988) Botulinum toxin injections for voiding dysfunction following SCI. J Spinal Cord Med 21:227–229

    Google Scholar 

  10. Duchen LW (1970) Changes in motor innervation and cholinesterase localization induced by botulinum toxin in skeletal muscle of the mouse: differences between fast and slow muscles. J Neurol Neurosurg Psychiatry 33:40

    Article  PubMed  CAS  Google Scholar 

  11. Borodic GE, Joseph M, Fay L et al (1990) Botulinum toxin for the treatment of spasmodic torticollis: dysphagia and regional toxin spread. Head Neck 12:392

    Article  PubMed  CAS  Google Scholar 

  12. Lazzeri M (2003) New pharmacological tools. Urodynamica 13:67–73

    Google Scholar 

  13. Nolan J, Chalkiadis GA, Low J et al (2000) Anaesthesia and pain management in cerebral palsy. Anaesthesia 55:32–41

    Article  PubMed  CAS  Google Scholar 

  14. Schurch B, Hauri D, Rodic B (1996) Botulinum-A toxin as a treatment of detrusor-sphincter dyssynergia: a prospective study in 24 spinal cord injury patients. J Urol 155:1023–1029

    Article  PubMed  CAS  Google Scholar 

  15. Deseze M, Petit H, Gallien P et al (2002) Botulinum A toxin and detrusor sphincter dyssynergia: a double blind lidocaine controlled study in 13 patients with spinal cord disease. Eur Urol 42:56–62

    Article  PubMed  CAS  Google Scholar 

  16. Phelan MW, Franks M, Somoyogi GT et al (2001) Botulinum toxin urethral sphincter injection to restore bladder emptying in men and women with voiding dysfunction. J Urol 165:1107–1110

    Article  PubMed  CAS  Google Scholar 

  17. Gallien P, Robineau S, Verin M et al (1998) Treatment of detrusor sphincter dyssynergia by transperineal injection of botulinum toxin. Arch Phys Med Rehabil 79:715–717

    Article  PubMed  CAS  Google Scholar 

  18. Plevnik S, Janez J (1979) Maximal electrical stimulation for urinary incontinence: report of 98 cases. Urology 14(6):638–645

    Article  PubMed  CAS  Google Scholar 

  19. Litwiller SE, Frohman EM, Zimmern P (1999) Multiple sclerosis and the urologist. J Urol 161:743–757

    Article  PubMed  CAS  Google Scholar 

  20. Schurch B, Stohrer M, Kramer D (2000) Botulinum A toxin for treating detrusor hyperreflaxia in spinal cord injured patients: a new alternative to anticholinergic drugs? Preliminary results. J Urol 164:692–697

    Article  PubMed  CAS  Google Scholar 

  21. Schulte-Baukloh H, Michael T, Schobert J (2002) Efficacy of botulinum A toxin in children with detrusor hyperreflexia due to myelomeningocele: preliminary results. Urology 59(3):325–328

    Article  PubMed  CAS  Google Scholar 

  22. Elliot DS, Boone TB (2000) Recent advances in the management of the neurogenic bladder. Urology 56(Suppl 6A):76–81

    Article  Google Scholar 

  23. Kuo HC (2004 May) Urodynamic evidence of effectiveness of botulinum A toxin injection in treatment of detrusor overactivity refractory to anticholinergic agents. J Urol 63(5):868–872

    Article  Google Scholar 

  24. Reitz A, Von Tobel J et al (2002) European experience of 184 cases treated with botulinum-A toxin injections into the detrusor muscle for neurogenic incontinence. Neurol Urodyn 21:427–428

    Google Scholar 

  25. Reitz A, Stohrer M, Kramer G et al (2004) European experience of 200 cases treated with botulinum-A toxin injections into the detrusor muscle for urinary incontinence due to neurogenic detrusor overactivity. Eur Urol 45(4):510–515, April

    Article  PubMed  CAS  Google Scholar 

  26. Maria G, Destitio A, Lacquanti S (1998) Relief by botulinum toxin of voiding dysfunction due to prostatitis. Lancet 352:625

    Article  PubMed  CAS  Google Scholar 

  27. Zermann DH, Ishigooka M, Doggweiller-Wiygul R et al (2000) Perisphincteric injection of botulinum toxin type A. A treatment option in patients with chronic prostatic pain? Eur Urol 38(4):393–399

    Article  PubMed  CAS  Google Scholar 

  28. Kuo H (2003) Effect of botulinum A toxin in the treatment of voiding dysfunction due to detrusor underactivity. Urology 61(3):550–554

    Article  PubMed  Google Scholar 

  29. Fowler CF, Betts CD, Christmas TJ et al (1992) Botulinum toxin in the treatment of chronic urinary retention in women. Br J Urol 70:387–389

    PubMed  CAS  Google Scholar 

  30. Giannantoni A, Mearnini E, Di Stasi SM et al (2004) New therapeutic options for refractory neurogenic detrusor overactivity. Minerva Urol Nefrol 56(1):79–87, March

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Ali Thwaini.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Thwaini, A., Shergill, I., Radhakrishnan, S. et al. Botox in urology. Int Urogynecol J 17, 536–540 (2006). https://doi.org/10.1007/s00192-005-0028-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00192-005-0028-z

Keywords

Navigation