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Effects of tamoxifen on Doppler velocimetry parameters of periurethral vessels in postmenopausal women

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Abstract

The purpose of the present study was to assess the effect of tamoxifen on periurethral vessels by Doppler velocimetry examination. Increase in the number of these vessels as well as decrease in resistance and pulsatility indices by tamoxifen were observed.

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References

  1. Klutke JJ, Bergman A (1995) Hormonal influence on the urinary tract. Urol Clin North Am 22:629–639

    Google Scholar 

  2. Sartori MGF, Baracat EC, Girão MJBC, et al. (1995) Menopausal genuine stress urinary incontinence treated with conjugated estrogens plus progestogens. Int J Gynaecol Obstet 49:165–169

    Article  CAS  PubMed  Google Scholar 

  3. Greene JL, Gilna P, Waterfield M, Baker A, et al. (1986) Sequence and expression of human estrogen receptor complementary DNA. Science 231:1150–1154

    CAS  PubMed  Google Scholar 

  4. Kuiper GGJM, Enmark E, Pelto-Huikko M, et al. (1996) Cloning of a novel estrogen receptor expressed in rat prostate and ovary. Proc Natl Acad Sci U S A 93:5925–5930

    Google Scholar 

  5. Mosselman S, Polman J, Dijkema R (1996) ER β: identification and characterization of a novel human estrogen receptor. FEBS Lett 392:49–53

    Article  CAS  PubMed  Google Scholar 

  6. Ogawa S, Inoue S, Watanabe T, et al. (1998) The complete primary structure of human estrogen receptor β (hERβ) and its heterodimerization with ER α in vivo and in vitro. Biochem Biophys Res Commun 243:122–126

    Google Scholar 

  7. Iosif CS, Batra S, Ek A, et al. (1981) Estrogen receptor in the human female lower urinary tract. Am J Obstet Gynecol 141:817–820

    CAS  PubMed  Google Scholar 

  8. Suguita M, Girão MJBC, Simões MJA, et al. (2000) A morphologic and morphometric study of the vesical mucosa and urethra of castrated female rats following estrogen and/or progestogen replacement. Clin Exp Obstet Gynecol 27:176–178

    CAS  PubMed  Google Scholar 

  9. Endo RM, Girão MJBC, Sartori MGF, et al. (2000) Effect of estrogen-progestogen hormonal replacement therapy on periurethral and bladder vessels. Int Urogynecol J 11:120–123

    Article  CAS  Google Scholar 

  10. Raz S, Caine M, Zeigler M (1972) The vascular component in the production of intraurethral pressure. J Urol 108:93–96

    CAS  PubMed  Google Scholar 

  11. Rud T, Andersson KE, Asmussen M, et al. (1980) Factors maintaining the intraurethral pressure in women. Invest Urol (Berl) 17:343–347

    Google Scholar 

  12. Gosling RG, Dumbar G, King DH, et al. (1971) The quantitative analysis of occlusive peripheral arterial disease by a non-intrusive ultrasonic technique. Angiology 22:52–55

    CAS  PubMed  Google Scholar 

  13. Pourcelot L (1975) Indications de l’ultrasonographie doppler dans l’etude des vaisseaux périphériques. Rev Prat 25:4671–4680

    CAS  PubMed  Google Scholar 

  14. Stuart B, Drumm J, Fitzgerald DE, et al. (1980) Fetal blood velocity waveforms in normal pregnancy. Br J Obstet Gynecol 87:780–785

    CAS  Google Scholar 

  15. Jármy-Di Bella ZIK, Girão MJBC, Sartori MGF, et al. (2000) Power Doppler of the urethra in continent or incontinent, pre and postmenopausal women. Int Urogynecol J 11:148–155

    Google Scholar 

  16. Girão MJBC, Jármy-Di Bella ZIK, Sartori MGF, et al. (2001) Dopplervelocimetry parameters of periurethral vessels in postmenopausal incontinent women receiving estrogen replacement. Int Urogynecol J 12:241–246

    Google Scholar 

  17. Goldstein SR (1998) Selective estrogen receptor modulators: a new category of therapeutic agents for extending the health of postmenopausal women. Am J Obstet Gynecol 179:1479–1484

    CAS  PubMed  Google Scholar 

  18. Jordan VC (1997) Tamoxifen: the herald of a new era of preventive therapeutics. J Natl Cancer Inst 89:747–749

    Article  CAS  PubMed  Google Scholar 

  19. Iosif CS, al-Hijji J, Samsioe G (2002) Effects of tamoxifen and estradiol on estrogen binding sites in the urogenital tract: an experimental study in the rabbit. Gynecol Endocrinol 16:379–383

    CAS  PubMed  Google Scholar 

  20. Vardy M, Lindsay R, Scotti R, et al. (2003) Short-term urogenital effects of raloxifene, tamoxifen, and estrogen. Am J Obstet Gynecol 189:81–88

    Article  CAS  PubMed  Google Scholar 

  21. Iguchi T, Hirokawa M, Takasugi N (1986) Occurrence of genital tract abnormalities and bladder hernia in female mice exposed neonattaly to tamoxifen. Toxicology 42:1-11

    Article  CAS  PubMed  Google Scholar 

  22. Fisher B, Constantini JP, Redmond CK, et al. (1994) Endometrial cancer in tamoxifen-treated breast cancer patients: findings from the National Surgical Adjuvant Breast and Bowel Project (NSABP) B-14. J Natl Cancer Inst 86:527–537

    Article  CAS  PubMed  Google Scholar 

  23. Fraiser LH, Kanekal S, Kehrer, JP (1991) Cyclophosphamide toxicity—characterising and avoiding the problem. Drugs 42:781–795

    CAS  PubMed  Google Scholar 

  24. Marks LB, Carrol PR, Dugen TC, et al. (1995) The response of the urinary bladder, urethra and ureter to radiation and chemotherapy. Int J Radiat Oncol Biol Phys 31:1257–1280

    Article  CAS  PubMed  Google Scholar 

  25. Caetano JPL, Faria MML, Lins RM, et al. (1996) Princípios básicos e aplicações da dopplervelocimetria em ginecologia e obstetrícia. J Bras Ginecol 106:233–242

    Google Scholar 

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Correspondence to Manoel J. B. C. Girão.

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Editorial Comment: This study of the effects of a SERM on the periurethral vessels is quite timely in light of the rampant decrease in hormone therapy. We expect to see an increase in women using a SERM for the indication of osteoporosis. In future, we look forward to studies that will demonstrate a connection between the flood flow to the urethra and lower urinary tract function. This may lead to more directed topical therapies

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Faria, C.A., Sartori, M.G.F., Baracat, E.C. et al. Effects of tamoxifen on Doppler velocimetry parameters of periurethral vessels in postmenopausal women. Int Urogynecol J 16, 56–59 (2005). https://doi.org/10.1007/s00192-004-1212-2

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  • DOI: https://doi.org/10.1007/s00192-004-1212-2

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