Skip to main content
SpringerLink
Log in

Proton pump inhibitors and nitric oxide mechanisms in type 2 diabetes

  • Letter
  • Published:
Diabetologia Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Abbreviations

PPI:

Proton pump inhibitor

References

  1. Hove KD, Brøns C, Faerch K et al (2013) Effects of 12 weeks' treatment with a proton pump inhibitor on insulin secretion, glucose metabolism and markers of cardiovascular risk in patients with type 2 diabetes: a randomised double-blind prospective placebo-controlled study. Diabetologia 56:22–30

    Article  PubMed  CAS  Google Scholar 

  2. Lundberg JO, Weitzberg E, Gladwin MT (2008) The nitrate–nitrite–nitric oxide pathway in physiology and therapeutics. Nat Rev Drug Discov 7:156–167

    Article  PubMed  CAS  Google Scholar 

  3. Dejam A, Hunter CJ, Tremonti C et al (2007) Nitrite infusion in humans and nonhuman primates: endocrine effects, pharmacokinetics, and tolerance formation. Circulation 116:1821–1831

    Article  PubMed  CAS  Google Scholar 

  4. Kapil V, Milsom AB, Okorie M et al (2010) Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO. Hypertension 56:274–281

    Article  PubMed  CAS  Google Scholar 

  5. Montenegro MF, Amaral JH, Pinheiro LC et al (2011) Sodium nitrite downregulates vascular NADPH oxidase and exerts antihypertensive effects in hypertension. Free Radic Biol Med 51:144–152

    Article  PubMed  CAS  Google Scholar 

  6. Pinheiro LC, Montenegro MF, Amaral JH, Ferreira GC, Oliveira AM, Tanus-Santos JE (2012) Increase in gastric pH reduces hypotensive effect of oral sodium nitrite in rats. Free Radic Biol Med 53:701–709

    Article  PubMed  CAS  Google Scholar 

  7. Amaral JH, Montenegro MF, Pinheiro LC et al (2013) TEMPOL enhances the antihypertensive effects of sodium nitrite by mechanisms facilitating nitrite-derived gastric nitric oxide formation. Free Radic Biol Med 65c:446–455

    Article  PubMed  Google Scholar 

  8. Carlstrom M, Larsen FJ, Nystrom T et al (2010) Dietary inorganic nitrate reverses features of metabolic syndrome in endothelial nitric oxide synthase-deficient mice. Proc Natl Acad Sci U S A 107:17716–17720

    Article  PubMed  CAS  Google Scholar 

Download references

Duality of interest

The author declares that there is no duality of interest associated with this manuscript.

Contribution statement

The author was the sole contributor to this paper.

Author information

Authors and Affiliations

  1. Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Av. Bandeirantes, 3900, 14049-900, Ribeirao Preto, SP, Brazil

    Jonas T. C. Sertorio

Authors
  1. Jonas T. C. Sertorio
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jonas T. C. Sertorio.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sertorio, J.T.C. Proton pump inhibitors and nitric oxide mechanisms in type 2 diabetes. Diabetologia 56, 2763–2764 (2013). https://doi.org/10.1007/s00125-013-3054-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00125-013-3054-2

Keywords

Search

Navigation