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Volumetrie von Metastasen beim Nierenzellkarzinom

Vergleich mit den RECIST-Kriterien

Volumetry of metastases from renal cell carcinoma

Comparison with the RECIST criteria

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Zusammenfassung

Bei Patienten mit metastasiertem Nierenzellkarzinom werden an die Bildgebung besondere Anforderungen gestellt. Die Therapie beruht heute in den meisten Fällen auf antiangiogenetischen Wirkstoffen, die im Verlauf teils zu relativ geringen Größenänderungen von Läsionen führen. Daher sind die oftmals verwendeten RECIST-Kriterien („response evaluation criteria in solid tumors“) bei der Beurteilung des Therapieansprechens als ungenau anzusehen. In diesem Artikel wird ein Überblick über neue, softwarebasierte volumetrische Methoden gegeben, die es ermöglichen, therapieinduzierte Größenänderungen von Metastasen beim Nierenzellkarzinom mit höherer Sensitivität und Reproduzierbarkeit zu detektieren. Anhand eigener Daten wird ein Vergleich von RECIST und Volumetrie bei Patienten mit metastasiertem Nierenzellkarzinom durchgeführt und die höhere Sensitivität des automatisierten Verfahrens gezeigt.

Abstract

For patients with metastasized renal cell carcinoma (RCC), imaging techniques are of great importance. Currently, therapy widely relies on antiangiogenic factors, which frequently lead to relatively subtle changes in the size of lesions. From this aspect the commonly used RECIST criteria (response evaluation criteria in solid tumors) must be considered as imprecise for the evaluation of the response to therapy. This article gives a review on new software-based volumetric methods, which allow therapy-induced changes in the size of metastases from RCC to be detected with higher sensitivity and reproducibility. A comparison of RECIST and volumetry was carried out with data from patients with metastasized RCC to demonstrate the higher sensitivity of the 3D volumetric procedure.

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Authors and Affiliations

  1. Institut für Klinische Radiologie, Klinikum Großhadern der Ludwig-Maximilians-Universität München, Marchioninistr. 15, 81377, München, Deutschland

    A. Graser, C.R. Becker & M.F. Reiser

  2. Klinik und Poliklinik für Urologie, Klinikum Großhadern der Ludwig-Maximilians-Universität München, München, Deutschland

    C. Stief & M. Staehler

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  1. A. Graser
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  2. C.R. Becker
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  3. M.F. Reiser
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  4. C. Stief
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  5. M. Staehler
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Correspondence to A. Graser.

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Graser, A., Becker, C., Reiser, M. et al. Volumetrie von Metastasen beim Nierenzellkarzinom. Radiologe 48, 850–856 (2008). https://doi.org/10.1007/s00117-008-1743-5

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  • DOI: https://doi.org/10.1007/s00117-008-1743-5

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