Skip to main content
SpringerLink
Log in

Basistherapie der Psoriasis vulgaris

Maintenance therapy of psoriasis

  • Leitthema
  • Published:
Der Hautarzt Aims and scope Submit manuscript

Zusammenfassung

Die Basistherapie wird als obligater Bestandteil eines therapeutischen Konzepts der Psoriasis verstanden. Die therapeutische Effektivität einer Basistherapie ergibt sich dabei vordergründig durch die Beeinflussung physikochemischer Charakteristika einzelner Kompartimente des Hautorgans, insbesondere des Stratum corneum und der vitalen Epidermis. Ziel ist die Beeinflussung des pathologischen Milieus hin zu physiologischen Bedingungen. Diese Effekte können durch pharmakologische oder biochemische Wirkungen enthaltener Wirksubstanzen oder Substanzgemische ergänzt werden. Schwerpunkte sind die Verwendung lipophiler Grundlagen sowie keratoplastischer, antiseptischer und antipruriginöser Zusätze.

Abstract

Maintenance therapy in the interval between flares is an essential part of the therapeutic approach to psoriasis. The therapeutic effectiveness of maintenance therapy results from a positive influence on the physicochemical characteristics of individual compartments of the skin, especially the stratum corneum and the epidermis. The objective is revert from a pathological milieu toward a physiological one. These effects may be supplemented by pharmacological or biochemical effects of the active substances or substance mixtures. Focal points are the use of lipophilic bases as well as keratoplastic, antiseptic and antipruriginous additives.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Literatur

  1. Bikowski J (2001) The use of therapeutic moisturizers in various dermatologic disorders. Cutis 68: 3–11

    PubMed  Google Scholar 

  2. Burr S (2000) Using emollients. Nurs Times 96: 15

    Google Scholar 

  3. Comaish JS, Greener JS (1976) The inhibiting effect of soft paraffin on the Kobner response in psoriasis. Br J Dermatol 94: 195–200

    PubMed  Google Scholar 

  4. Cowen P (2001) Management of psoriasis. Aust Fam Physician 30: 1033–1037

    PubMed  Google Scholar 

  5. Cox NH, Sharpe G (1990) Emollients, salicylic acid, and ultraviolet erythema. Lancet 335: 53–54

    Article  Google Scholar 

  6. Dunn ML, Cockerline EB, Rice MR (1988) Treatment options for psoriasis. Am J Nurs 88: 1081–1087

    PubMed  Google Scholar 

  7. Editor (1998) Antiseptic/emollient combinations. Drug Ther Bull 36: 84–86

    PubMed  Google Scholar 

  8. Escobar SO, Achenbach R, Iannantuono R, Torem V (1992) Topical fish oil in psoriasis--a controlled and blind study. Clin Exp Dermatol 17: 159–162

    Article  PubMed  Google Scholar 

  9. Fairhurst DA, Ashcroft DM, Griffiths CE (2005) Optimal management of severe plaque form of psoriasis. Am J Clin Dermatol 6: 283–294

    Article  PubMed  Google Scholar 

  10. Fisher AA (1981) Allantoin: a non-sensitizing topical medicament. Therapeutic effects of the addition of 5 percent allantoin to Vaseline. Cutis 27: 230–1, 234, 329

    PubMed  Google Scholar 

  11. Helm TN, Ferrara RJ Jr, Dijkstra J, Soukup J (1989) New improved Nivea oil cannot be used alone as vehicle for salicylic acid. J Am Acad Dermatol 21: 814

    Google Scholar 

  12. Kristensen B, Kristensen O (1991) Topical salicylic acid interferes with UVB therapy for psoriasis. Acta Derm Venereol 71: 37–40

    PubMed  Google Scholar 

  13. Limaye S, Weightman W (1997) Effect of an ointment containing boric acid, zinc oxide, starch and petrolatum on psoriasis. Australas J Dermatol 38: 185–186

    PubMed  Google Scholar 

  14. Loden M (2003) Role of topical emollients and moisturizers in the treatment of dry skin barrier disorders. Am J Clin Dermatol 4: 771–788

    Article  PubMed  Google Scholar 

  15. Neubert R, Wohlrab W, Marsch WC (2001) Dermatopharmazie. Wissenschaftliche Verlagsgesellschaft mbH, Stuttgart

  16. Newbold PC (1980) Comparison of four emollients in the treatment of various skin conditions. Practitioner 224: 205–206

    PubMed  Google Scholar 

  17. Nola I, Kostovic K, Kotrulja L, Lugovic L (2003) The use of emollients as sophisticated therapy in dermatology. Acta Dermatovenerol Croat 11: 80–87

    PubMed  Google Scholar 

  18. Nyfors A (1973) Fucidin in psoriasis. A double-blind study of twenty psoriatics over two periods of four weeks each. Dermatologica 146: 281–284

    PubMed  Google Scholar 

  19. Rim JH, Jo SJ, Park JY et al. (2005) Electrical measurement of moisturizing effect on skin hydration and barrier function in psoriasis patients. Clin Exp Dermatol 30: 409–413

    Article  PubMed  Google Scholar 

  20. Schaefer H, Redelmeier TE (1996) Skin Barrier. Karger, Basel

  21. Schleider NR, Moskowitz RS, Cort DH et al. (1979) Effects of emollients on ultraviolet-radiation-induced erythema of the skin. Arch Dermatol 115: 1188–1191

    Article  PubMed  Google Scholar 

  22. Subramanyan K (2004) Role of mild cleansing in the management of patient skin. Dermatol Ther 17 [Suppl 1]: 26–34

    Google Scholar 

  23. Sulzberger MB, Obadia A J (1956) A modified liquid petrolatum preparation; its use in the management of certain common dermatoses of the scalp. AMA Arch Derm 73: 373–375

    PubMed  Google Scholar 

  24. Voegeli D (2005) Skin hygiene practices, emollient therapy and skin vulnerability. Nurs Times 101: 57, 59

    Google Scholar 

  25. Watsky KL, Freije L, Leneveu MC et al. (1992) Water-in-oil emollients as steroid-sparing adjunctive therapy in the treatment of psoriasis. Cutis 50: 383–386

    PubMed  Google Scholar 

  26. Welzel J, Wilhelm KP, Wolff HH (1996) Skin permeability barrier and occlusion: no delay of repair in irritated human skin. Contact Dermatitis 35: 163–168

    Article  PubMed  Google Scholar 

  27. Witman PM (2001) Topical therapies for localized psoriasis. Mayo Clin Proc 76: 943–949

    PubMed  Google Scholar 

  28. Witten VH, Stein SJ, Michaelides P (1963) Use of thin pliable plastic film in selected dermatoses. A controlled evaluation. Arch Dermatol 87: 458–461

    PubMed  Google Scholar 

  29. Wohlrab J (2005) Adjuvante Therapie der atopischen Dermatitis. Shaker, Aachen

  30. Wolf G, Süverkrüp R (2002) Rezepturen. Dt. Apotheker Verlag, Stuttgart

Download references

Interessenkonflikt

Es besteht kein Interessenkonflikt. Der korrespondierende Autor versichert, dass keine Verbindungen mit einer Firma, deren Produkt in dem Artikel genannt ist, oder einer Firma, die ein Konkurrenzprodukt vertreibt, bestehen. Die Präsentation des Themas ist unabhängig und die Darstellung der Inhalte produktneutral.

Author information

Authors and Affiliations

  1. Universitätsklinik und Poliklinik für Dermatologie und Venerologie, Institut für angewandte Dermatopharmazie, Martin-Luther-Universität Halle-Wittenberg, Ernst-Kromayer-Straße 5, 06097 , Halle

    J. Wohlrab

Authors
  1. J. Wohlrab
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to J. Wohlrab.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wohlrab, J. Basistherapie der Psoriasis vulgaris. Hautarzt 57, 661–665 (2006). https://doi.org/10.1007/s00105-006-1169-9

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00105-006-1169-9

Schlüsselwörter

Keywords

Search

Navigation