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Synthesis and antimicrobial screening of some novel chalcones and flavanones substituted with higher alkyl chains

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Abstract

As a part of our program to generate some novel flavonoid frameworks substituted with higher alkyl groups as possible antimicrobial agents, we have in total synthesized twelve novel chalcones (11–16) and their corresponding flavanones (17–22) substituted with either nonyl or dodecyl chains in ring B in very good to excellent yields. The synthesized compounds have been screened for their antimicrobial potential against six bacterial and four fungal strains. The tested compounds, in general, showed significant antibacterial and comparable antifungal activities. While the chalcone (16) with a dodecyl chain showed highly promising antibacterial activity against almost all the organisms tested, the chalcone (13) with nonyl chain showed promising antifungal activity against Candida rugosa and Aspergillus niger strains.

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Acknowledgments

We are highly thankful to the Director, CSIR-IICT, Hyderabad, India for support and encouragement.

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Author notes

  1. Laxmidhar Sahoo

    Present address: Sai Life Sciences, Hyderabad, India

Authors and Affiliations

  1. Natural Products Chemistry Division, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad, 500 607, India

    Uppuluri Venkata Mallavadhani & Laxmidhar Sahoo

  2. Biology Division, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad, 500607, India

    Koochana Pranay Kumar & Upadyayula Suryanarayana Murty

Authors
  1. Uppuluri Venkata Mallavadhani
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  2. Laxmidhar Sahoo
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  3. Koochana Pranay Kumar
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  4. Upadyayula Suryanarayana Murty
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Correspondence to Uppuluri Venkata Mallavadhani.

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Mallavadhani, U.V., Sahoo, L., Kumar, K.P. et al. Synthesis and antimicrobial screening of some novel chalcones and flavanones substituted with higher alkyl chains. Med Chem Res 23, 2900–2908 (2014). https://doi.org/10.1007/s00044-013-0876-x

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  • DOI: https://doi.org/10.1007/s00044-013-0876-x

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