Abstract
A series of 6-substituted-1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazole (6a–g) and 1,3,4-oxadiazole (7a–g, 8) derivatives of benzothiazole were synthesized in satisfactory yield and pharmacologically evaluated for their anti-inflammatory, analgesic, ulcerogenic, and lipid peroxidation activities by known experimental models. All the synthesized compounds were in good agreement with elemental and spectral data. Some of the synthesized compounds have significant anti-inflammatory and analgesic activities. Ulcerogenic and irritative action on the gastrointestinal mucosa, in comparison with standard are low.
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Acknowledgments
The authors are thankful to the Head of the Department, Pharmaceutical Chemistry for providing laboratory facilities, Central Drug Research Institute (CDRI) for spectral analysis of the compounds. Authors are also thankful in-charge, animal house, Jamia Hamdard, for providing Wistar rats and Dr. A. Mukherjee, M.D., Department of Pathology, All India Institute of Medical Sciences (AIIMS), New Delhi, for carrying out histopathological studies.
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Gilani, S.J., Khan, S.A. Synthesis and pharmacological evaluation of N-(6-chlorobenzo[d]thiazol-2-yl)hydrazine carboxamide derivatives of benzothiazole. Med Chem Res 22, 3316–3328 (2013). https://doi.org/10.1007/s00044-012-0329-y
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DOI: https://doi.org/10.1007/s00044-012-0329-y