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Synthesis and antimicrobial activity of some (3-phenyl-5-(1-phenyl-3-aryl-1H-pyrazol-4-yl)-4,5-dihydro-1H-pyrazol-1-yl)(pyridin-4-yl)methanones: new derivatives of 1,3,5-trisubstituted pyrazolines

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Abstract

A series of (3-phenyl-5-(1-phenyl-3-aryl-1H-pyrazol-4-yl)-4,5-dihydro-1H-pyrazol-1-yl)(pyridin-4-yl)methanones was synthesized by condensing suitably substituted chalcones, i.e., 3-(3-aryl-1-phenyl-1H-pyrazol-4-yl)-1-phenylprop-2-en-1-ones, and isoniazid in acetic acid. The structure of newly synthesized compounds has been established on the basis of analytical and spectral data. The new compounds were screened for antimicrobial activity and most of them showed good activity comparable with that of standard drugs ciprofloxacin and fluconazole. Compounds containing methoxy group showed high antimicrobial activity.

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Acknowledgments

Financial support by UGC, New Delhi, is gratefully acknowledged. Thanks to Mr Ashwani Kumar, GJUST-Hisar, for his valuable suggestions for carrying out antimicrobial activity.

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Authors and Affiliations

  1. Department of Chemistry, Govt P G College, Hisar, 125001, India

    Satyender Kumar & Sunil Kumar

  2. Department of Chemistry, Guru Jambheshwar University of Science & Technology, Hisar, Haryana, 125001, India

    Meenakshi

  3. Department of Chemistry, Kurukshetra University, Kurukshetra, 136119, India

    Parvin Kumar

Authors
  1. Satyender Kumar
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  2. Meenakshi
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  3. Sunil Kumar
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  4. Parvin Kumar
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Correspondence to Parvin Kumar.

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Kumar, S., Meenakshi, Kumar, S. et al. Synthesis and antimicrobial activity of some (3-phenyl-5-(1-phenyl-3-aryl-1H-pyrazol-4-yl)-4,5-dihydro-1H-pyrazol-1-yl)(pyridin-4-yl)methanones: new derivatives of 1,3,5-trisubstituted pyrazolines. Med Chem Res 22, 433–439 (2013). https://doi.org/10.1007/s00044-012-0045-7

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  • DOI: https://doi.org/10.1007/s00044-012-0045-7

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