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Targeting Nrf-2 is a promising intervention approach for the prevention of ethanol-induced liver disease

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Abstract

Alcoholic liver disease (ALD) remains to be a worldwide health problem. It is generally accepted that oxidative stress plays critical roles in the pathogenesis of ALD, and antioxidant therapy represents a logical strategy for the prevention and treatment of ALD. Nuclear factor erythroid-derived 2-like 2 (NFE2L2 or Nrf-2) is essential for the antioxidant responsive element (ARE)-mediated induction of endogenous antioxidant enzymes such as heme oxygenase 1 (HO-1) and glutamate–cysteine ligase [GCL, the rate-limiting enzyme in the synthesis of glutathione (GSH)]. Activation of Nrf-2 pathway by genetic manipulation or pharmacological agents has been demonstrated to provide protection against ALD, which suggests that targeting Nrf-2 may be a promising approach for the prevention and treatment of ALD. Herein, we review the relevant literature about the potential hepatoprotective roles of Nrf-2 activation against ALD.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (Grant No. 81473004 and 81102153), the key Research and Develop Project of Shandong Province (Grant No. 2017GSF18122), the Young Scholars Program of Shandong University (Grant No. 2015WLJH52), and the Project for the Traditional Chinese Medicine of Shandong Province (Grant No. 2013-167).

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Authors and Affiliations

  1. Institute of Toxicology, School of Public Health, Shandong University, 44 Wenhua West Road, Jinan, 250012, Shandong, China

    Ning Zhao, Ke-Qin Xie & Tao Zeng

  2. Department of Pharmacy, Qilu Hospital of Shandong University, 107 Wenhua West Road, Jinan, 250012, Shandong, China

    Fang-Fang Guo

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  1. Ning Zhao
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  4. Tao Zeng
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Correspondence to Tao Zeng.

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Zhao, N., Guo, FF., Xie, KQ. et al. Targeting Nrf-2 is a promising intervention approach for the prevention of ethanol-induced liver disease. Cell. Mol. Life Sci. 75, 3143–3157 (2018). https://doi.org/10.1007/s00018-018-2852-6

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