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Mitochondrial control of caspase-dependent and -independent cell death

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Abstract

Mitochondria control whether a cell lives or dies. The role mitochondria play in deciding the fate of a cell was first identified in the mid-1990s, because mitochondria-enriched fractions were found to be necessary for activation of death proteases, the caspases, in a cell-free model of apoptotic cell death. Mitochondrial involvement in apoptosis was subsequently shown to be regulated by Bcl-2, a protein that was known to contribute to cancer in specific circumstances. The important role of mitochondria in promoting caspase activation has therefore been a major focus of apoptosis research; however, it is also clear that mitochondria contribute to cell death by caspase-independent mechanisms. In this review, we will highlight recent findings and discuss the mechanism underlying the mitochondrial control of apoptosis and caspase-independent cell death.

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Acknowledgments

We would like to thank Dr. Waterhouse (Mater Medical Research Institute, Brisbane, Australia) for critical reading of this manuscript. This work was supported in part by grants from Association pour la Recherche sur le Cancer (ARC), l’Agence Nationale de la Recherche (ref ANR-09-JCJC-0003-01), la Fondation de France and Région Provence-Alpes-Cote-d’Azur. J-E.R. is a recipient of a contrat d’interface INSERM-CHU de Nice.

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  1. Inserm, U895, Centre Méditerranéen de Médecine Moléculaire (C3M), équipe 3 AVENIR, 06204, Nice Cedex 3, France

    Ludivine A. Pradelli, Marie Bénéteau & Jean-Ehrland Ricci

  2. Université de Nice-Sophia-Antipolis, Faculté de Médecine, 06107, Nice Cedex 2, France

    Ludivine A. Pradelli, Marie Bénéteau & Jean-Ehrland Ricci

  3. Centre Hospitalier Universitaire de Nice, Département d’Anesthésie Réanimation, 06202, Nice Cedex 3, France

    Jean-Ehrland Ricci

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  1. Ludivine A. Pradelli
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Pradelli, L.A., Bénéteau, M. & Ricci, JE. Mitochondrial control of caspase-dependent and -independent cell death. Cell. Mol. Life Sci. 67, 1589–1597 (2010). https://doi.org/10.1007/s00018-010-0285-y

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