Summary
WithStaphylococcus aureus in a synthetic medium the action of 2000 mg/l sulfanilamide can be completely antagonized by a series of four non competitive antagonistsviz., methionine, xanthine, thymine and valine. Pteroylglutamic acid cannot replace thymine.
The implication is that the four enzyme systems leading to these substances are inhibited by increasing concentrations of sulfanilamide.
Serine is not a competitive antagonist forS.aureus, such as it is forE.coli. It seems that the serine synthesizing enzyme present inE.coli is absent inS.aureus.
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References
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XII: Antonie van Leeuwenhoek15, 129, 1949.
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de Haan, P.G., Winkler, K.C. & Baljet, H. On the action of sulfanilamide. Antonie van Leeuwenhoek 15, 136–142 (1949). https://doi.org/10.1007/BF02062640
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DOI: https://doi.org/10.1007/BF02062640