Skip to main content
SpringerLink
Log in

Structure-activity relationship of the cardenolides derived from digoxigenin and digitoxigenin, with special reference to the configuration at C-5

  • Pharmacologica
  • Published:
Experientia Aims and scope Submit manuscript

Zusammenfassung

Es wurden die kardiotonischen Wirkungen des Digoxigenins, sowie deren 5 Derivate, einschliesslich des 5α-Digoxigenins, auf das isolierte Forschherz untersucht und Vergleiche mit den entsprechenden Aglykonen der Digitoxigenin-Reihe gezogen.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Literatur

  1. L. Masler, Š. Bauer, O. Bauerová andD. Šikl. Colln. Czech. chem. Commun.27, 895 (1962).

    Article  CAS  Google Scholar 

  2. M. Okada andT. Anjyo, Chem. Pharm. Bull. Tokyo, to be published.

  3. T. Shigei andS. Mineshita, Experientia24, 466 (1968).

    Article  CAS  Google Scholar 

  4. K. Takeda, T. Shigei andS. Imai, Experimentia26, 867 (1970).

    Article  CAS  Google Scholar 

  5. T. Shigei, H. Tsuru, Y. Saito andM. Okada, Experimentia29, 449 (1973).

    Article  CAS  Google Scholar 

  6. T. Reichstein, Naturwissenschaften54, 53 (1967).

    Article  CAS  Google Scholar 

  7. K. K. Chen, A. Rev. Physiol.7, 677 (1945).K. K. Chen andF. G. Henderson Archs int. Pharmacodyn. Thér.140, 8 (1962).

    Article  CAS  Google Scholar 

  8. K. Repke, Proc. 2nd Int. Pharmac. Meeting (Pergamon Press, New York 1965), vol. 5., p. 65.

    Google Scholar 

  9. A. L. Abeles, J. gen. Physiol.52, 268 (1969).

    Article  Google Scholar 

  10. Ch. Tamm, Proc. 1st Int. Pharmac. Meeting (Pergamon Press, New York 1963), vol. 3, p. 11.

    Google Scholar 

  11. K. H. R. Repke andH. J. Portius, Planta med., Suppl.4, 66 (1971).

    Article  Google Scholar 

  12. K. D. Roberts, Ek. Weiss andT. Reichstein, Helv. chim. Acta49, 316 (1966).

    Article  CAS  Google Scholar 

  13. This study was supported in part by a research grant No. 787012 from the Ministry of Education Japan.

Download references

Author information

Author notes

  1. N. Ishikawa, H. Tsuru & T. Shigei

    Present address: Department of Pharmacology, Nagoya University, School of Medicine, Tsurumai-cho, Showa-ku, 466, Nagova, Japan

  2. T. Amjyo & M. Okada

    Present address: Tokyo, Biochemical Research Institute, Takada, Toshima-ku, 171, Tokyo, Japan

Authors and Affiliations

  1. Department of Pharmacology, Nagoya University, School of Medicine, Tsurumai-cho, Showa-ku, 466, Nagoya, Japan

    N. Ishikawa, H. Tsuru, T. Shigei, T. Amjyo & M. Okada

  2. Tokyo Bichemical Research Institute, Takada, Toshima-ku, 171, Fokyo, Japan

    N. Ishikawa, H. Tsuru, T. Shigei, T. Amjyo & M. Okada

  3. Department of Pharmacology, Nagoya University, School of Medicine, Tsurumai-cho, Showa-ku, 466, Nagova, Japan

    T. Amjyo & M. Okada

  4. Tokyo, Biochemical Research Institute, Takada, Toshima-ku, 171, Tokyo, Japan

    N. Ishikawa, H. Tsuru & T. Shigei

Authors
  1. N. Ishikawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. H. Tsuru
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. T. Shigei
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. T. Amjyo
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. M. Okada
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ishikawa, N., Tsuru, H., Shigei, T. et al. Structure-activity relationship of the cardenolides derived from digoxigenin and digitoxigenin, with special reference to the configuration at C-5. Experientia 30, 1308–1310 (1974). https://doi.org/10.1007/BF01945201

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01945201

Keywords

Search

Navigation