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Controlling the degradation of pH/temperature-sensitive injectable hydrogels based on poly(β-amino ester)

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Abstract

Poly (ethylene glycol) (PEG) — poly(ε-caprolactone(CL)-co-D,L-lactide (LA)) (PCLA-PEG-PCLA) was synthesized by ring-opening polymerization to form a temperature sensitive hydrogel triblock copolymer. Poly(β-amino ester) (PAE) obtained from 1,4-butanediol diacrylate (BDA), and 4,4′-trimethylene dipiperidine (TMDP) was used as a pH sensitive moiety to conjugate to the triblock copolymer. The physicochemical properties of the temperature-sensitive triblock and pH/temperature-sensitive pentablock copolymers (PAE-PCLA-PEG-PCLA-PAE) were characterized by 1H NMR spectroscopy and gel permeation spectroscopy. The sol-gel phase transition behavior of the PAE-PCLA-PEG-PCLA-PAE block copolymers was investigated. An aqueous solution of the copolymers (20 wt%) changed from a sol phase at pH 6.4 and 10°C to a gel phase at pH 7.4 and 37°C. In addition, the degradation of PAE-PCLA-PEG-PCLA-PAE was compared with that of poly(ethylene glycol) — poly(ε-caprolactone) — poly (β-amino ester) (PAE-PCL-PEG-PCL-PAE) using both in vitro and in vivo experiments. The relationship between the insulin release profile from the matrix and the degradation of these materials also investigated.

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Authors and Affiliations

  1. Department of Polymer Science and Engineering, SungKyunKwan University, Gyeonggi, 440-746, Korea

    Dai Phu Huynh, Minh Khanh Nguyen & Doo Sung Lee

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  1. Dai Phu Huynh
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  2. Minh Khanh Nguyen
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  3. Doo Sung Lee
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Correspondence to Doo Sung Lee.

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Huynh, D.P., Nguyen, M.K. & Lee, D.S. Controlling the degradation of pH/temperature-sensitive injectable hydrogels based on poly(β-amino ester). Macromol. Res. 18, 192–199 (2010). https://doi.org/10.1007/s13233-009-0182-0

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  • DOI: https://doi.org/10.1007/s13233-009-0182-0

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