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Physical and mechanical properties of alginate-based hydrogel film as carrier for release of acetylthiocholine

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Abstract

The effects of different cross-linkers on mechanical and physical properties of alginate hydrogel films were determined to use prepared films as potential carrier structure for rapid detection system. Xylitol and d-mannitol cross-linked hydrogel films improved mechanical properties and generated more rigid, tough and stretchable film than uncross-linked film. Results exhibited increased tensile strength by 2.3 folds (58.3±5.8 MPa) and 1.8 folds (47.4±4.9MPa) when compared to uncross-linked film (25.8±7.3 MPa) respectively. Young’s modulus of d-mannitol cross-linked film was slightly greater (16.8±2.1 MPa) than that of xylitol (15.7±2.7 MPa) whereas the elongation at break (E%) value of xylitol cross-linking (5.46±1.2%) was greater than d-mannitol (2.72±0.8%) cross-linking. Altered mechanical properties were investigated in terms of different amount of % cumulative release of AchI and DTNB that were immobilized in film matrix. Results showed different release amount depending on types of cross-linkers as following: xylitolcrosslinked (71.5%) > d-mannitol (64.9%) > uncross-linked (58.3%) at 10 min of release period. The exponent value n which determined based on power-law expression was ranged between 0.56 and 0.98, and indicates the release was mediated by anomalous Non-Fickian diffusion.

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Author notes

  1. SungYun Park and Wan-Joong Kim contributed equally to this work

Authors and Affiliations

  1. College of Korean Medicine, Dongguk University, 32, Dongguk-ro, Ilsandong-gu, Goyang-si, Gyeonggi-do, 10326, Republic of Korea

    Sung Yun Park

  2. DMX Corporation, 1184, Yuseong-daero, Yuseong-gu, Daejeon, 34109, Republic of Korea

    Wan-Joong Kim

  3. Department of Mechanical Systems Engineering, Hansung University, 116, Samseongyo-ro 16-gil, Seongbuk-gu, Seoul, 02876, Republic of Korea

    Jae Bong Choi & Sanghee Kim

Authors
  1. Sung Yun Park
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  2. Wan-Joong Kim
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  3. Jae Bong Choi
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  4. Sanghee Kim
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Correspondence to Sanghee Kim.

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Park, S.Y., Kim, WJ., Choi, J.B. et al. Physical and mechanical properties of alginate-based hydrogel film as carrier for release of acetylthiocholine. Int. J. Precis. Eng. Manuf. 19, 129–135 (2018). https://doi.org/10.1007/s12541-018-0015-1

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  • DOI: https://doi.org/10.1007/s12541-018-0015-1

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