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Layered double hydroxide modified by PEGylated hyaluronic acid as a hybrid nanocarrier for targeted drug delivery

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Abstract

In recent years, organic-inorganic hybrid nanocarriers are explored for effective drug delivery and preferable disease treatments. In this study, using 5-fluorouracil(5-FU)as electronegative model drug, a new type of organic-inorganic hybrid drug delivery system(LDH/HA-PEG/5-FU)was conceived and manufactured by the adsorption of PEGylated hyaluronic acid(HA-PEG)on the surface of layered double hydroxide(LDH, prepared via hydrothermal method)and the intercalation of 5-FU in the interlamination of LDH via ion exchange strategy. The drug loading amount of LDH/HA-PEG/5-FU achieved as high as 34.2%. LDH, LDH/5-FU and LDH/HA-PEG/5- FU were characterized by FT-IR, XRD, TGA, laser particle size analyzer and SEM. With the benefit of pHdegradable feature of LDH and enzyme-degradable feature of HA, LDH/HA-PEG/5-FU showed pH-degradable and enzyme-degradable capacity in in vitro drug release. Moreover, the drug carrier LDH/HA-PEG contained biocompatible PEG and tumor-targeted HA, resulting in lower cytotoxicity and better endocytosis compared with LDH in vitro. It was suggested that the organic-inorganic hybrid drug delivery system, which was endowed with the properties of controlled release, low toxicity and tumor-targeting delivery for ameliorative cancer therapy, was advisable and might be applied further to fulfill other treatments.

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Authors and Affiliations

  1. Key Laboratory of Systems Bioengineering of Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, China

    Anjie Dong  (董岸杰), Xue Li  (李 雪), Shangcong Han  (韩尚聪), Shuxin Xu  (许舒欣) & Liandong Deng  (邓联东)

  2. Collaborative Innovation Center of Chemical Science and Engineering(Tianjin), Tianjin, 300072, China

    Anjie Dong  (董岸杰)

  3. Tianjin Key Laboratory of Radiation Molecular and Molecular Nuclear Medicine, Institute of Radiation Medicine, Chinese Academy of Medical Science and Peking Union Medical College, Tianjin, 300192, China

    Jianfeng Liu  (刘鉴锋) & Jinjian Liu  (刘金剑)

  4. Tianjin Key Laboratory of Biomaterial Research, Institute of Biomedical Engineering, Chinese Academy of Medical Science, Tianjin, 300192, China

    Weiwei Wang  (王伟伟)

  5. School of Materials Science and Engineering, Tianjin Polytechnic University, Tianjin, 300387, China

    Junqiang Zhao  (赵军强)

Authors
  1. Anjie Dong  (董岸杰)
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  2. Xue Li  (李 雪)
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  4. Shangcong Han  (韩尚聪)
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  6. Jinjian Liu  (刘金剑)
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  7. Junqiang Zhao  (赵军强)
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  8. Shuxin Xu  (许舒欣)
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  9. Liandong Deng  (邓联东)
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Corresponding author

Correspondence to Liandong Deng  (邓联东).

Additional information

Supported by the National Natural Science Foundation of China(No. 81371667, No. 31271073).

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Dong, A., Li, X., Wang, W. et al. Layered double hydroxide modified by PEGylated hyaluronic acid as a hybrid nanocarrier for targeted drug delivery. Trans. Tianjin Univ. 22, 237–246 (2016). https://doi.org/10.1007/s12209-016-2710-2

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  • DOI: https://doi.org/10.1007/s12209-016-2710-2

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