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Mésothéliome péritonéal : mise au point

Focus on peritoneal mesothelioma

  • Article / Article
  • Published:
Journal Africain d'Hépato-Gastroentérologie

Résumé

Objectif

Effectuer une mise au point sur le mésothéliome péritonéal en mettant l’accent sur son étiopathogénie; ses aspects cliniques, paracliniques et thérapeutiques.

Méthode

Revue systématique non exhaustive de la littérature portant sur le mésothéliome péritonéal, cherchant à standardiser la démarche diagnostique et thérapeutique.

Résultats

Les mésothéliomes sont des tumeurs rares, développées aux dépens des cavités coelomiques, les localisations de mésothéliome par ordre décroissant sont la plèvre, le péritoine et le péricarde. L’incidence du mésothéliome péritonéal est de 0,5 à 3 cas/million d’habitants. L’exposition à l’amiante constitue le principal facteur de risque de cette pathologie. Le diagnostic repose sur l’examen anatomopathologique avec étude immunohistochimique. Le traitement est fondé sur une chirurgie de cytoréduction associée à une chimiothérapie intrapéritonéale hyperthermique pour les formes accessibles à la chirurgie, et une chimiothérapie systémique pour les formes disséminées à base de pemetrexed–cisplatine.

Abstract

Objective

To establish the current state of peritoneal mesothelioma focusing on its pathogenesis and clinical and therapeutic particularities.

Method

A literature review concerning the peritoneal mesothelioma was conducted, trying to standardize the diagnostic and therapeutic approach.

Results

Mesotheliomas are rare tumors, developed at the expense of coelomic cavities; the peritoneum is the second most frequent origin site of mesothelioma, after the pleura, and followed by pericardium. The incidence of peritoneal mesothelioma is 0.5–3 cases/million habitants. The asbestos exposure is the primary risk factor for this disease. Diagnosis is based on histological examination with immunohistochemical stain. The treatment is based on a debulking surgery with intraperitoneal hyperthermic chemotherapy for localized forms, and systemic chemotherapy based on pemetrexed–cisplatin for disseminated disease.

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Authors and Affiliations

  1. Département d’oncologie médicale, Institut national d’oncologie, Rabat, 10000, Maroc

    H. Ettahri, O. Akkar, N. Salmi, A. Lakhdissi, M. Layachi, L. Elamarti, S. Boutayeb & H. Errihani

  2. Service d’hépatogastroentérologie B, CHU Ibn-Sina, Rabat, Maroc

    S. Rais

  3. Université Mohammed-V-Souissi, Rabat, 8007, Maroc

    H. Ettahri, O. Akkar, S. Rais, N. Salmi, A. Lakhdissi, M. Layachi, L. Elamarti, S. Boutayeb & H. Errihani

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  1. H. Ettahri
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  2. O. Akkar
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  3. S. Rais
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  4. N. Salmi
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  8. S. Boutayeb
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  9. H. Errihani
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Ettahri, H., Akkar, O., Rais, S. et al. Mésothéliome péritonéal : mise au point. J Afr Hepato Gastroenterol 10, 179–183 (2016). https://doi.org/10.1007/s12157-016-0674-4

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  • DOI: https://doi.org/10.1007/s12157-016-0674-4

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