Skip to main content
Log in

Complete atrioventricular block induced by rituximab in monotherapy in an aged patient with non-Hodgkin’s diffuse large B-cell lymphoma

  • Case Reports
  • Published:
Clinical and Translational Oncology Aims and scope Submit manuscript

Abstract

Rituximab is a treatment option to non-Hodgkin’s diffuse large B-cell lymphoma (NHDLBCL) in advanced stage and comorbility. It is known the cardiotoxicity effect of this drug, but there is no previous report describing a complete atrioventricular block (CAVB) secundary to treatment with Rituximab. We present an elderly woman treated with monotherapy with Rituximab who experienced a CAVB after administration of the fifth dose of this drug.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Coiffier B, Lepage E, Briere J et al (2002) CHOP chemoterapy plus rituximab compared with CHOP alone in ederly patients with diffuse large-B-cell lymphoma. New Engl J Med 346:235–242

    Article  PubMed  CAS  Google Scholar 

  2. The International Non-Hodgkin’s Lymphoma Prognostic Factor Project (1993) A predictive model for aggressive non-Hodgkin’s lymphoma. N Engl J Med 329:987

    Article  Google Scholar 

  3. Rodriguez J, Cabanillas F, McLaughlin P et al (1992) A proposal for a simple staging system for intermediate grade lymphoma and immunoblastic lymphoma based on the “tumor score”. Ann Oncol 3:711

    PubMed  CAS  Google Scholar 

  4. Cerny T, Borisch B, Introna M et al (2002) Mechanism of action of rituximab. Anticancer Drugs 13[Suppl 2]:S3–S10

    PubMed  CAS  Google Scholar 

  5. Coma-Canella I, Macias A, Varo N, Sanchez Ibarrola A (2005) Neurohormones and cytokines in heart failure. Correlation with coronary flow reserve. Rev Esp Cardiol 58:1273–1277

    Article  PubMed  Google Scholar 

  6. Tsushima K, Yamaguchi S, Furihata K et al (2001) A case of renal cell carcinoma complicated with interstitial pneumonitis, complete A-V block and pleural effusion during interferon-alpha therapy. Nihon Kokyuki Gakkai Zasshi 39:893–898

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to José Manuel Cervera Grau.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Cervera Grau, J.M., Galiana, G.E., Candela, A.B. et al. Complete atrioventricular block induced by rituximab in monotherapy in an aged patient with non-Hodgkin’s diffuse large B-cell lymphoma. Clin Transl Oncol 10, 298–299 (2008). https://doi.org/10.1007/s12094-008-0201-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12094-008-0201-1

Keywords

Navigation