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Synthesis of size-controllable Fe3O4 magnetic submicroparticles and its biocompatible evaluation in vitro

  • Materials, Metallurgy, Chemical and Environmental Engineering
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Abstract

Large scaled uniform and size-controllable magnetic submicroparticles (MSPs) were synthesized via solvothermal method with ferric chloride as iron source and sodium acetate as trapping agent. The influence of Fe3+ and NaAc contents on the size distribution of MSPs was investigated. The structural and morphological properties of the synthesized particles were studied by scanning electron microscopy (SEM), X-ray power diffraction (XRD) and vibrating sample magnetometer (VSM). The well-dispersed MSPs with size of 100-1000 nm were obtained by simply adjusting the contents of Fe3+ and NaAc. In addition, the hemolysis and cytotoxicity of Fe3O4 MSPs, and their ability to case arrest in cell life-cycles were studied. The results indicate that larger size could lead to lower hemolysis. From MTT(3-(4,5-dimethylthuazol-2-yl)-2,5-diphenyltetrazolium bromide) assay, the interactions between MSPs and adhesive mouse fibroblast cell line(L929) were probed. Larger size of Fe3O4 MSPs demonstrates lower cell viability following an exposure to the cells.

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Authors and Affiliations

  1. School of Metallurgy and Enviroment, Cental South University, Changsha, 410083, China

    Qing-hua Tian  (田庆华), Wen-bo Ning  (宁文博), Wei-jia Wang  (王惟嘉) & Xiu-hong Yuan  (袁秀洪)

  2. Haikou Municipal People’s Hospital, Haikou, 570100, China

    Zhi-ming Bai  (白志明)

Authors
  1. Qing-hua Tian  (田庆华)
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  2. Wen-bo Ning  (宁文博)
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  3. Wei-jia Wang  (王惟嘉)
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  4. Xiu-hong Yuan  (袁秀洪)
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  5. Zhi-ming Bai  (白志明)
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Correspondence to Qing-hua Tian  (田庆华).

Additional information

Foundation item: Project(2013DFA5129) supported by the International Science and Technology Cooperation Program of China

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Tian, Qh., Ning, Wb., Wang, Wj. et al. Synthesis of size-controllable Fe3O4 magnetic submicroparticles and its biocompatible evaluation in vitro. J. Cent. South Univ. 23, 2784–2791 (2016). https://doi.org/10.1007/s11771-016-3341-4

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  • DOI: https://doi.org/10.1007/s11771-016-3341-4

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