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Surveillance des lésions anales précancéreuses et prévention

Monitoring of pre-cancerous anal lesions and preventative measures

  • Dossier Thématique / Thematic File
  • Published:
Côlon & Rectum

Résumé

La prévalence des lésions liées à human papillomavirus (HPV) et la forte augmentation d’incidence du cancer anal chez les patients infectés par le VIH imposent un dépistage systématique dans cette population. Les facteurs de risque en dehors de l’homosexualité et de l’infection VIH sont: les partenaires multiples et des antécédents d’infection sexuellement transmissible (IST). Le dépistage à recommander, en 2008, est un examen proctologique complet avec anuscopie par un opérateur expérimenté. La fréquence des récidives impose un suivi régulier de ces patients.

Abstract

The prevalence of human papillomavirus (HPV) induced lesions and a significant increase in the incidence of anal cancer in patients infected by HIV mean that systematic screening is now necessary in this population. Risk factors, other than homosexuality and HIV infection, are: multiple partners and a history of sexually transmitted infections. In 2008 it is recommended that screening should involve a complete proctological examination with anoscopy, performed by an experienced operator. Frequency of recurrence means that such patients should be regularly monitored.

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Références

  1. Biggar RJ, Burnett W, Mikl J, Nasca P (1989) Cancer among New York men at risk of acquired immunodeficiency syndrome. Int J Cancer 43: 979–985

    Article  PubMed  CAS  Google Scholar 

  2. Daling JR, Weiss NS, Hislop TG, et al. (1987) Sexual practices, sexually transmitted diseases, and the incidence of anal cancer. N Engl J Med 317: 973–977

    PubMed  CAS  Google Scholar 

  3. Melbye M, Sprogel P (1991) Aetiological parallel between anal cancer and cervical cancer. Lancet 338: 657–659

    Article  PubMed  CAS  Google Scholar 

  4. Daling JR, Madeleine MM, Johnson LG, et al. (2004) Human papillomavirus, smoking, and sexual practices in the etiology of anal cancer. Cancer 101: 270–280

    Article  PubMed  Google Scholar 

  5. Schiffman M, Castle PE, Jeronimo J, et al. (2007) Human papillomavirus and cervical cancer. Lancet 370: 890–907

    Article  PubMed  CAS  Google Scholar 

  6. Woodman CB, Collins S, Winter H, et al. (2001) Natural history of cervical human papillomavirus infection in young women: a longitudinal cohort study. Lancet 357: 1831–1836

    Article  PubMed  CAS  Google Scholar 

  7. Ho GY, Bierman R, Beardsley L, et al. (1998) Natural history of cervicovaginal papillomavirus infection in young women. N Engl J Med 338: 423–428

    Article  PubMed  CAS  Google Scholar 

  8. Sobhani I, Walker F, Roudot-Thoraval F, et al. (2004) Anal carcinoma: incidence and effect of cumulative infections. AIDS 18: 1561–1569

    Article  PubMed  Google Scholar 

  9. Breese PL, Judson FN, Penley KA, et al. (1995) Anal human papillomavirus infection among homosexual and bisexual men: prevalence of type-specific infection and association with human immunodeficiency virus. Sex Transm Dis 22: 7–14

    Article  PubMed  CAS  Google Scholar 

  10. Weaver BA, Feng Q, Holmes KK, et al. (2004) Evaluation of genital sites and sampling techniques for detection of human papillomavirus DNA in men. J Infect Dis 189: 677–685

    Article  PubMed  CAS  Google Scholar 

  11. Palefsky JM, Holly EA, Ralston ML, et al. (1998) Anal squamous intraepithelial lesions in HIV-positive and HIV-negative homosexual and bisexual men: prevalence and risk factors. J Acquir Immune Defic Syndr Hum Retrovirol 17: 320–326

    PubMed  CAS  Google Scholar 

  12. Koutsky LA, Ault KA, Wheeler CM, et al. (2002) A controlled trial of a human papillomavirus type 16 vaccine. N Engl J Med 347: 1645–1651

    Article  PubMed  CAS  Google Scholar 

  13. Harper DM, Franco EL, Wheeler C, et al. (2004) Efficacy of a bivalent L1 virus-like particle vaccine in prevention of infection with human papillomavirus types 16 and 18 in young women: a randomised controlled trial. Lancet 364: 1757–1765

    Article  PubMed  CAS  Google Scholar 

  14. Palefsky JM, Berry JM, Jay N, et al. (2006) A trial of SGN-00101 (HspE7) to treat high-grade anal intraepithelial neoplasia in HIV-positive individuals. AIDS (London, England) 20: 1151–1155

    CAS  Google Scholar 

  15. Saliba G, Yeni P (2006) Recent and future therapeutic advances in the management of HIV infection. Pathol Biol 54: 545–550

    Article  PubMed  CAS  Google Scholar 

  16. Pineda CE, Berry JM, Jay N, et al. (2008) High-resolution anoscopy targeted surgical destruction of anal high-grade squamous intraepithelial lesions: a ten-year experience. Dis Colon Rectum 51: 829–835

    Article  PubMed  Google Scholar 

  17. Abramowitz L, Benabderrahmane D, Ravaud P, et al. (2007) Anal squamous intraepithelial lesions and condyloma in HIV-infected heterosexual men, homosexual men and women: prevalence and associated factors. AIDS 21: 1457–1465

    Article  PubMed  Google Scholar 

  18. Edgren G, Sparen P (2007) Risk of anogenital cancer after diagnosis of cervical intraepithelial neoplasia: a prospective population-based study. Lancet Oncol 8: 311–316

    Article  PubMed  Google Scholar 

  19. Ogunbiyi OA, Scholefield JH, Raftery AT, et al. (1994) Prevalence of anal human papillomavirus infection and intraepithelial neoplasia in renal allograft recipients. Br J Surg 81: 365–367

    Article  PubMed  CAS  Google Scholar 

  20. Chiao EY, Giordano TP, Palefsky JM, et al. (2006) Screening HIV-infected individuals for anal cancer precursor lesions: a systematic review. Clin Infect Dis 43: 223–233

    Article  PubMed  Google Scholar 

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Correspondence to L. Abramowitz.

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Abramowitz, L., Aparicio, T. Surveillance des lésions anales précancéreuses et prévention. Colon Rectum 2, 138–144 (2008). https://doi.org/10.1007/s11725-008-0106-8

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  • DOI: https://doi.org/10.1007/s11725-008-0106-8

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