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Nickel-catalyzed enantioselective hydrovinylation of silyl-protected allylic alcohols: An efficient access to homoallylic alcohols with a chiral quaternary center

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Abstract

Asymmetric hydrovinylation of silyl-protected allylic alcohols catalyzed by nickel complexes of chiral spiro phosphoramidite ligands was developed. A series of homoallylic alcohols with a chiral quaternary center were produced in high yields (up to 97%) and high enantioselectivities (up to 95% ee). The reaction provides an efficient method for preparing bifunctional compounds with a chiral quaternary carbon center.

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Correspondence to Qi-Lin Zhou.

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Zhang, Q., Zhu, SF., Cai, Y. et al. Nickel-catalyzed enantioselective hydrovinylation of silyl-protected allylic alcohols: An efficient access to homoallylic alcohols with a chiral quaternary center. Sci. China Chem. 53, 1899–1906 (2010). https://doi.org/10.1007/s11426-010-4036-6

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  • DOI: https://doi.org/10.1007/s11426-010-4036-6

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