Abstract
Three new CoIII complexes: [Co(bpy)2(pdtb)]3+ (1), [Co(bpy)2(pdta)]3+ (2) and [Co(bpy)2(pdtp)]3+ (3) have been synthesized and characterized. The DNA binding behavior of the CoIII complexes has been investigated by spectroscopic methods and viscosity measurements. The results indicate that the size and shape of the intercalated ligand have a marked effect on the binding affinity of complexes involving CT-DNA. Complexes (2) and (3) have been found to promote cleavage of plasmid pBR 322 DNA from the supercoiled form I to the open circular form II upon irradiation. Photocleavage mechanisms are proposed.
Similar content being viewed by others
References
C.J. Burrows S.E. Rokita (1994) Acc. Chem. Res. 27 295 Occurrence Handle10.1021/ar00046a002
A. Sigel H. Sigel (Eds) (1996) Metal Ions in Biological Systems vol. 33 Marcel Dekker New York
G. Pratviel J. Bernadou B. Meunier (1998) Adv. Inorg. Chem. 45 251
K.E. Erkkila D.T. Odom J.K. Barton (1999) Chem. Rev. 99 2777 Occurrence Handle10.1021/cr9804341 Occurrence Handle11749500
J.A. Cowan (2001) Curr. Opin. Chem. Biol 5 634 Occurrence Handle10.1016/S1367-5931(01)00259-9 Occurrence Handle11738172
Y. Xiong L.-N. Ji (1999) Coord. Chem. Rev. 185–186 711 Occurrence Handle10.1016/S0010-8545(99)00019-3
L.-N. Ji X.-H. Zou J.-G. Liu (2001) Coord. Chem. Rev. 216–217 513 Occurrence Handle10.1016/S0010-8545(01)00338-1
L.-N. Ji Q.-L. Zhang H. Chao (2001) Chinese Sci. Bull. 46 1332
C. Turro S.H. Bossman Y. Jenkins J.K. Barton N.J. Turro (1995) J. Am. Chem. Soc. 117 9026 Occurrence Handle10.1021/ja00140a020
A. Ambroise B.G. Maiya (2000) Inorg. Chem. 39 4256 Occurrence Handle10.1021/ic991468+ Occurrence Handle11196920
E. Tuite P. Lincolin B. Nordén (1997) J. Am. Chem. Soc. 119 239 Occurrence Handle10.1021/ja961857s
D.Z.M. Coggan I.S. Haworth P.J. Bates A. Robinson A. Rodger (1999) Inorg. Chem. 38 4486 Occurrence Handle10.1021/ic990654c Occurrence Handle11671161
R.J. Morgan S. Chatterjee A.D. Baker T.C. Strekas (1991) Inorg. Chem. 30 2687 Occurrence Handle10.1021/ic00012a023
X.-H. Zou B.-H. Ye H. Li Q.-L. Zhang H. Chao J.-G. Liu L.-N. Ji (2000) J. Biol. Inorg. Chem. 6 143
H. Chao W.-J. Mei Q.-W. Huang L.-N. Ji (2002) J. Inorg. Biochem. 92 165 Occurrence Handle10.1016/S0162-0134(02)00543-3 Occurrence Handle12433424
X.-L. Wang H. Chao H. Li X.-L. Hong L.-N. Ji X.-Y. Li (2004) J. Inorg. Biochem. 98 423 Occurrence Handle10.1016/j.jinorgbio.2003.12.006 Occurrence Handle14987842
X.-L. Hong H. Chao L.-J. Lin K.-C. Zheng H. Li X.-L Wang F.-C. Yun L.-N Ji (2004) Helv. Chim. Acta. 87 1180
X.-L. Wang H. Chao H. Li X.-L. Hong Y.-J. Liu L.-F. Tan L.-N. Ji (2004) J. Inorg. Biochem. 98 1143 Occurrence Handle15149826
C.V. Kumar N.J. Turro J.K. Barton (1985) J. Am. Chem. Soc. 107 5518
J. Marmur (1961) J. Mol. Biol. 3 208
A.A. Vlcek (1967) Inorg. Chem. 6 1425
M.F. Reichmann S.A. Rice C.A. Thomas P. Doty (1954) J. Am. Chem. Soc. 76 3047 Occurrence Handle10.1021/ja01640a067
J.B. Chaires N. Dattagupta D.M. Crothers (1982) Biochemistry 21 3933 Occurrence Handle7126524
G. Cohen H. Eisenberg (1969) Biopolymers 8 45
J.K. Barton A.T. Danishefsky J.M. Goldberg (1984) J. Am. Chem. Soc. 106 2172 Occurrence Handle10.1021/ja00319a043
S.A. Tysoe R.J. Morgan A.D. Baker T.C. Strekas (1993) J. Phys. Chem. 97 1707 Occurrence Handle10.1021/j100110a038
T.M. Kelly A.B. Tossi D.J. McConnell T.C. Strekas (1985) Nucleic Acids Res. 13 6017 Occurrence Handle4047939
R.P. Hertzberg P.B. Dervan (1982) J. Am. Chem. Soc. 104 313 Occurrence Handle10.1021/ja00365a069
A.M. Pyle and J.K. Barton, in S.J. Lippard (Eds.), Progress in Inorganic Chemistry: Bioinorganic Chemistry, Wiley, New York, 1990, vol. 38, p 413.
J.R. Lakowicz G. Webber (1973) Biochemistry 12 4161 Occurrence Handle4795686
S. Satyanarayana J.C. Dabroniak J.B. Chaires (1992) Biochemistry 31 9319 Occurrence Handle1390718
S. Satyanaryana J.C. Daborusak J.B. Chaires (1993) Biochemistry 32 2573 Occurrence Handle8448115
H. Chao, G. Yang, G.-Q. Xue, H. Li, H. Zhang, I. D. Williams, L.-N. Ji, X.-M. Chen and X.-Y. Li, J. Chem. Soc., Dalton Trans., 1326 (2001).
Q.-L. Zhang J.-G. Liu H. Chao G.-Q. Xue L.-N. Ji (2001) J. Inorg. Biochem. 83 49 Occurrence Handle10.1016/S0162-0134(00)00132-X Occurrence Handle11192699
Q.-L. Zhang J.-G. Liu J.-Z. Liu H. Li Y. Yang H. Xu H. Chao L.-N. Ji (2002) Inorg. Chim. Acta. 339 34
R. Subramanian C.F. Meares (1986) J. Am. Chem. Soc. 108 6427
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Wang, XL., Chao, H., Hong, XL. et al. Bis(2,2′-bipyridine)cobalt(III) complexes containing asymmetric ligands: Synthesis, DNA-binding and photocleavage studies. Transition Met Chem 30, 305–311 (2005). https://doi.org/10.1007/s11243-004-4576-8
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/s11243-004-4576-8