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Mechanochemical preparation and pharmacological activities of water-soluble intermolecular complexes of arabinogalactan with medicinal agents

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Abstract

A possibility of mechanochemical preparation of water-soluble complexes of a plant polysaccharide arabinogalactan and poorly soluble medicinal agents (Sibazon(=Diazepam), Mezapam(=Medazepam), Indometacin, and Azaleptin(=Clozapine)) has been investigated. Their molecular dynamics (NMR relaxation method in solution) and some pharmacological properties have been studied in comparison with the original pharmaceutical drugs.

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Authors and Affiliations

  1. Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch of the Russian Academy of Sciences, 18 ul. Kutateladze, 630128, Novosibirsk, Russian Federation

    A. V. Dushkin & E. S. Meteleva

  2. Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, 9 prosp. Akad. Lavrent’eva, 630090, Novosibirsk, Russian Federation

    T. G. Tolstikova & G. A. Tolstikov

  3. Institute of Chemical Kinetics and Combustion, Siberian Branch of the Russian Academy of Sciences, 3 ul. Institutskaya, 630090, Novosibirsk, Russian Federation

    N. E. Polyakov

  4. A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, 1 ul. Favorskogo, 664033, Irkutsk, Russian Federation

    N. A. Neverova, E. N. Medvedeva & V. A. Babkin

Authors
  1. A. V. Dushkin
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  2. E. S. Meteleva
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  3. T. G. Tolstikova
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  4. G. A. Tolstikov
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  5. N. E. Polyakov
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  6. N. A. Neverova
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  7. E. N. Medvedeva
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  8. V. A. Babkin
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Corresponding author

Correspondence to A. V. Dushkin.

Additional information

Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 6, pp. 1274–1282, June, 2008.

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Dushkin, A.V., Meteleva, E.S., Tolstikova, T.G. et al. Mechanochemical preparation and pharmacological activities of water-soluble intermolecular complexes of arabinogalactan with medicinal agents. Russ Chem Bull 57, 1299–1307 (2008). https://doi.org/10.1007/s11172-008-0167-8

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  • DOI: https://doi.org/10.1007/s11172-008-0167-8

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