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Thermoanalytical study of some anti-inflammatory analgesic agents

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Abstract

Thermogravimetry (TG), differential thermal analysis (DTA), differential scanning calorimetry (DSC) as well as X-ray diffraction powder (DRX) patterns and Fourier transformed infrared spectroscopy (FTIR) were used to study ketoprofen, ibuprofen, and naproxen. The chemical or physical properties of the studied compounds were established and when possible by X-ray powder diffractometry and/or infrared spectroscopy were used. In this investigation, quantum chemical approach was used to determine the molecular structures using Becke three-parameter hybrid method and the Lee–Yang–Par (LYP) correlation functional. The performed molecular calculations in this work were done using the Gaussian 03 routine. Theoretical calculations help in interpretations of FTIR spectra supplying structural and physicochemical parameters.

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Acknowledgements

The authors thank FAPESP (Proc. 2008/04296; 2006/06951-3), CNPq and CAPES foundation (Brazil) for financial support and computational facilities of CENAPAD-UNICAMP.

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Authors and Affiliations

  1. Falculdade de Ciências – UNESP – Departamento de Química, Buru, SP, CEP 17033-260, Brazil

    G. Bannach

  2. Universidade Estadual de Ponta Grossa – Depto. Química, Ponta Grossa, PR, CEP 84030-900, Brazil

    R. Arcaro, D. C. Ferroni & E. Schnitzler

  3. Universidade Federal do Mato Grosso, Pontal do Araguaia, MT, CEP 78698-000, Brazil

    A. B. Siqueira

  4. Instituto de Química de Química – UNESP, Araraquara, SP, CEP 14800-900, Brazil

    O. Treu-Filho & M. Ionashiro

Authors
  1. G. Bannach
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  2. R. Arcaro
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  3. D. C. Ferroni
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  4. A. B. Siqueira
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  5. O. Treu-Filho
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  6. M. Ionashiro
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  7. E. Schnitzler
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Correspondence to G. Bannach.

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Bannach, G., Arcaro, R., Ferroni, D.C. et al. Thermoanalytical study of some anti-inflammatory analgesic agents. J Therm Anal Calorim 102, 163–170 (2010). https://doi.org/10.1007/s10973-010-0939-x

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  • DOI: https://doi.org/10.1007/s10973-010-0939-x

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