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Thermal characterization of the solid state and raw material fluconazole by thermal analysis and pyrolysis coupled to GC/MS

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Abstract

This article had studied the thermal characterization of the raw material and different fluconazole crystals, obtained through recrystallization with different solvents using thermoanalytical techniques (TG, DTA, DSC-50, DSC Photovisual, DSC-60) and Pyr-GC/MS. The results confirmed that the fluconazole volatilizes without decomposition until 250 °C. Pyr-GC/MS showed hexachlorobenzene like impurities in fluconazole raw material.

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Authors and Affiliations

  1. Pharmaceutical Sciences Department, Federal University of Pernambuco—UFPE, Artur de Sá Avenue, Cidade Universitária, 740-521, Recife, PE, Brazil

    Elisana Afonso Moura, Lidiane Pinto Correia, Márcia Ferraz Pinto, José Valdilânio Virgulino Procópio & Rui Oliveira Macedo

  2. Unified Laboratories of Medicine Development and Assay—LUDEM, Federal University of Parahyba—UFPB, Campos I, 58059-900, João Pessoa, PB, Brazil

    Fábio Santos de Souza & Rui Oliveira Macedo

Authors
  1. Elisana Afonso Moura
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  2. Lidiane Pinto Correia
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  3. Márcia Ferraz Pinto
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  4. José Valdilânio Virgulino Procópio
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  5. Fábio Santos de Souza
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  6. Rui Oliveira Macedo
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Correspondence to Lidiane Pinto Correia.

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Moura, E.A., Correia, L.P., Pinto, M.F. et al. Thermal characterization of the solid state and raw material fluconazole by thermal analysis and pyrolysis coupled to GC/MS. J Therm Anal Calorim 100, 289–293 (2010). https://doi.org/10.1007/s10973-009-0473-x

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  • DOI: https://doi.org/10.1007/s10973-009-0473-x

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