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Interaction of amphiphilic derivatives of chitosan with DPPC (1,2-dipalmitoyl-sn-glycero-3-phosphocholine)

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Abstract

The interaction of chitosan and its N-dodecyl and poly(ethylene glycol) derivatives with 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) vesicles was studied to evaluate the influence of molecular architecture of the polymers on the liposomes. The study was carried out in aqueous solution using differential scanning microcalorimetry (DSC) and dynamic light scattering. The interaction of these polymers with DPPC vesicles altered the gel–liquid crystalline phase transition temperature and decreased both the enthalpy (ΔH) and cooperativity of the phase transition. The results obtained indicate that perturbations in the vesicles surface and the incorporation of chitosan and its derivatives into the lipid bilayer upon polysaccharides interaction are responsible for the formation of large vesicles.

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Acknowledgements

The authors would like to thank to Fapesp (Fundação de Amparo à Pesquisa do Estado de São Paulo, grant 2007/00339-7) and Capes, Brazil, for financial supporting of this work.

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Authors and Affiliations

  1. Departamento de Química e Ciências Ambientais, Instituto de Biociências Letras e Ciências Exatas, UNESP, São José do Rio Preto, SP, Brazil

    Vera Aparecida de Oliveira Tiera & Márcio José Tiera

  2. Faculty of Pharmacy and Department of Chemistry, Université de Montréal, Montreal, QC, Canada

    Françoise M. Winnik

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  1. Vera Aparecida de Oliveira Tiera
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  2. Françoise M. Winnik
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  3. Márcio José Tiera
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Correspondence to Vera Aparecida de Oliveira Tiera.

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de Oliveira Tiera, V.A., Winnik, F.M. & Tiera, M.J. Interaction of amphiphilic derivatives of chitosan with DPPC (1,2-dipalmitoyl-sn-glycero-3-phosphocholine). J Therm Anal Calorim 100, 309–313 (2010). https://doi.org/10.1007/s10973-009-0375-y

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  • DOI: https://doi.org/10.1007/s10973-009-0375-y

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