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Compatibility study between chlorpropamide and excipients in their physical mixtures

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Abstract

Chlorpropamide ((4-chloro-N-(propylamino)-carbonyl)-benzenesulfonamide) belongs to compounds having sulfonylurea group and is widely used as an oral antidiabetic agent. In this work differential scanning calorimetry (DSC) was used during pre-formulation of chlorpropamide tablets to determine the drug-excipients compatibility. The DSC curves of chlorpropamide and binary mixtures with excipients (sodium croscarmellose, sodium lauryl sulfate, microcrystalline cellulose, magnesium stearate and calcium carbonate) showed that chlorpropamide exhibited interaction with magnesium stearate and sodium lauryl sulfate. The binary mixtures of chlorpropamide–magnesium stearate presented a single endothermic process at 96–108 °C and chlorpropamide–sodium lauryl sulfate showed a wide endotherm at 99–120 °C.

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References

  1. Gilman AG, Hardman JG, Limbird LE, Molinoff PB, Ruddon RW. 9th ed. Rio de Janeiro: Goodman & Gilman.

  2. Guo J, Elzing PA, Hangeman MJ, Herron JN. Rapid throughput solubility screening method for bcs class II drugs in animal Gl Fluids and simulated human Gl Fluids using a 96-well format. J Pharm Sci. 2008;97:1427.

    Article  CAS  Google Scholar 

  3. Filho ROC, Franco PIBM, Conceição EC, Leles MIG. Stability studies on nifedipine tablets using thermogravimetry and differential scanning calorimetry. J Therm Anal Calorim. 2008;93:381–5.

    Article  CAS  Google Scholar 

  4. Santos AFO, Basilio ID, de Souza FS, Medeiros AFD, Pinto MF, de Santana DP, et al. Application of thermal analysis in study of binary mixtures with metformin. J Therm Anal Calorim. 2008;93:361–4.

    Article  CAS  Google Scholar 

  5. Filho MSSC, Pacheco RM, Landin M. Compatibility of the antitumoral β-lapachone with different solid dosage forms excipients. J Pharm Biomed Anal. 2007;45:590–8.

    Article  Google Scholar 

  6. Drebushchak VA, Drebushchak TN, Chukanov NV, Boldyreva EV. Transitions among five polymorphs of chlorpropamide near the melting point. J Therm Anal Calorim. 2008;93:343–51.

    Article  CAS  Google Scholar 

  7. Miller TA, York P. Physical and chemical characteristics of some high purity magnesium stearate and palmitate powders. Int J Pharm. 1985;23:55–67.

    Article  CAS  Google Scholar 

  8. Thirbert R, Hancock BC. Direct visualization of superdisintegrant hydration using environmental scanning electron microscopy. J Pharm Sci. 1996;85:1255–8.

    Article  Google Scholar 

  9. Pokharkar VB, Joshi BV, Patil VB. Compatibility studies between carbamazepine and tablet excipients using thermal and nonthermal methods. Drug Dev Ind Pharm. 2002;6:687–94.

    Google Scholar 

  10. Giron D. Applications of thermal analysis and coupled techniques in pharmaceutical industry. J Therm Anal Calorim. 2002;68:335–57.

    Article  CAS  Google Scholar 

  11. Heidarian M, Mihranyan A, Stromme M. Influence of water-cellulose binding energy on stability of acetylsalicylic acid. Int J Pharm. 2006;323:139–45.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The authors wish to thank the financing agent: NUPLAM/UFRN for the technical and financial support for this research.

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Authors and Affiliations

  1. Laboratório de Desenvolvimento de Medicamentos–Programa de Pós-Graduação em Ciências Farmacêuticas–Departamento de Farmácia, Universidade Federal do Rio Grande do Norte–UFRN, R. Brigadeiro Cordeiro de Farias, s/n, Petrópolis, Natal, CEP 59.010-180, RN, Brazil

    Fátima Duarte Freire, T. Flávio Accioly de Lima e Moura & Fernanda Nervo Raffin

  2. NUPLAM–Núcleo de Pesquisa em Alimentos e Medicamentos–Campus Universitário, s/n, Lagoa Nova, Natal, CEP 59078-970, RN, Brazil

    Fátima Duarte Freire, T. Flávio Accioly de Lima e Moura & Fernanda Nervo Raffin

  3. Laboratório de Controle de Qualidade de Medicamentos–Programa de Pós-Graduação em Ciências Farmacêuticas–Departamento de Farmácia, Universidade Federal do Rio Grande do Norte–UFRN, R. Brigadeiro Cordeiro de Farias, s/n, Petrópolis, Natal, CEP 59.010-180, RN, Brazil

    C. Flávio Soares Aragão

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  1. Fátima Duarte Freire
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  2. C. Flávio Soares Aragão
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  3. T. Flávio Accioly de Lima e Moura
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Correspondence to Fátima Duarte Freire.

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Freire, F.D., Aragão, C.F.S., de Lima e Moura, T.F.A. et al. Compatibility study between chlorpropamide and excipients in their physical mixtures. J Therm Anal Calorim 97, 355–357 (2009). https://doi.org/10.1007/s10973-009-0258-2

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  • DOI: https://doi.org/10.1007/s10973-009-0258-2

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