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tudy on compatibility of imatinib mesylate with pharmaceutical excipients

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Abstract

Differential scanning calorimetry and thermogravimetric analysis with the support of X-ray powder diffraction and infrared spectroscopy were used as screening techniques for the compatibility testing of imatinib mesylate, with following excipients: magnesium stearate, polyvinylpyrrolidone, microcrystalline cellulose. In order to maximize the probability of interactions 1:1 (by mass) drug: excipient binary mixtures were analysed and compared to individual components. Additionally an influence of storage at temperatures of 25 and 40°C on physico-chemical stability on drug – excipient binary mixtures was investigated.

The largest visible changes were observed in the DSC curves of imatinib mesylate – magnesium stearate mixtures.

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Authors and Affiliations

  1. Quality Control and R&D Analytical Chemistry Department, Pharmaceutical Research Institute, Warsaw, Poland, 01-793, Rydygiera 8

    M. Łaszcz, B. Kosmacińska, K. Korczak, B. Śmigielska, M. Glice, W. Maruszak, A. Groman & H. Beczkowicz

  2. Pharmaceutical Department, Pharmaceutical Research Institute, Warsaw, Poland, 01-793, Rydygiera 8

    Ł. Żelazko

Authors
  1. M. Łaszcz
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  2. B. Kosmacińska
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  3. K. Korczak
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  4. B. Śmigielska
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  5. M. Glice
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  6. W. Maruszak
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  7. A. Groman
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  8. H. Beczkowicz
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  9. Ł. Żelazko
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Correspondence to M. Łaszcz.

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Łaszcz, M., Kosmacińska, B., Korczak, K. et al. tudy on compatibility of imatinib mesylate with pharmaceutical excipients. J Therm Anal Calorim 88, 305–310 (2007). https://doi.org/10.1007/s10973-006-8001-8

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  • DOI: https://doi.org/10.1007/s10973-006-8001-8

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