Abstract
The synthesis of nanostructured magnetic materials has been intensively researched because of their large field of applications as magnetic carriers in drug targeting, hyperthermia in tumor treatment, among others. Much effort has been invested in magnetic nanoparticles for bioapplications. However, as these nanoparticles present high specific surface area, unprotected nanoparticles can easily form aggregates and react with oxygen in the air. They can also rapidly biodegrade when directly exposed to biological systems. In this context, we have explored the possibility of synthesizing a mesoporous SiO2–Fe3O4 nanocomposite and its AC magnetic-field-induced heating properties. The magnetite nanocomposite was obtained by impregnation of an iron precursor into a silica framework. The proposed method involves the preparation of an iron oxide precursor in ethanol and the subsequent impregnation of SBA-15 mesoporous hexagonal silica. Iron oxide was formed inside the porous structure, thus producing the magnetic device. The nanocomposite was characterized by X-ray diffraction (XRD), Fourier-transformed infrared spectroscopy (FTIR), N2 adsorption, scanning electron microscopy (SEM), and transmission electron microscopy (TEM). Measurements of AC magnetic-field-induced heating properties of the obtained nanocomposite, both of the solid form and in aqueous solution, under different applied magnetic fields showed that it is suitable as a hyperthermia agent for biological applications.
Similar content being viewed by others
References
Bruce IJ, Taylor J, Todd M, Davies MJ, Borioni E, Sangregorio C, Sem T (2009) J Magn Magn Mater 284:145–160
Azzazy HME, Mansour MMH (2009) Clinica Chimica Acta 403:1–8
Lee H, Lee E, Kim DK, Jang NK, Jeong YY, Jon S (2006) J Am Chem Soc 128:7383–7389
Kim TW, Chung PW, Slowing II, Tsunoda M, Yeung ES, Lin VSY (2008) Nano Lett 8:3724–3727
Qin J, Asempah I, Laurent S, Fornara A, Muller RN, Muhammed M (2009) Adv Mater 21:1354–1357
He YP, Wang SQ, Li CR, Miao YM, Wu ZY, Zou BS (2005) J Phys D-Appl Phys 38:1342–1350
Chastellain M, Petri A, Gupta A, Rao KV, Hofman H (2004) Adv Eng Mater 6:235–241
Julián-López B, Boissière C, Chanéac C, Grosso D, Vasseur S, Miraux S, Duguet E, Sanchez C (2007) J Mater Chem 17:1563–1569
Le Renard P-E, Buchegger F, Petri-Fink A, Bosman F, Rüfenacht D, Hofmann H, Doelker E, Jordan O (2009) Int J Hyperth 25:229–239
Kalambur VS, Han B, Hammer BE, Shield TW, Bischof JC (2005) Nanotechnology 16:1221–1233
Zhu Y, Wu Q (1999) J Nanopart Res 1:393–396
Konishi Y, Nomura T, Mizoe K (2004) Hydrometallurgy 74:57–65
Liu ZL, Wang X (2004) J Mater Sci 39:2633–2636
Franger S, Berthet P, Berthon J (2004) J Solid State Electrochem 8:218–223
Gun’ko YK, Pillai SC, Mcinerney D (2001) J Mater Sci Mater Electron 12:299–302
Wu M, Xiong Y, Jia Y, Niu H, Qi H, Ye J, Chen Q (2005) Chem Phys Lett 401:374–379
Khollam YB, Dhage SR, Potdar HS, Deshpande SB, Bakare PP, Kulkarni SD, Date SK (2002) Mater Lett 56:571–577
Zhang Z, Zhang L, Chen L, Chen L, Wan QH (2006) Biotechnol Prog 22:514–518
Zhao DL, Zeng XW, Xia QS, Tang JT (2009) J Alloys Compd 469:215–218
Wu JH, Ko SP, Liu HL, Jung MH, Lee JH, Ju JS, Kim YK (2008) Coll Surf A Physicochem Eng Aspects 313–314:268–272
Franger S, Berthet P, Dragos O, Baddour-Hadjean R, Bonville P, Berthon J (2007) J Nanoparticle Res 9:389–402
Souza KC, Ardisson JD, Sousa EMB (2009) J Mater Sci Mater Med 20:507–512
Sousa A, Souza KC, Reis SC, Sousa RG, Windmöller D, Machado JC, Sousa EMB (2008) J Non-Cryst Solids 354:4800–4805
Sousa A, Sousa EMB (2005) Arquivos de Biologia e Tecnologia 48:243–250
Souza KC, Salazar-Alvarez G, Ardisson JD, Macedo WAA, Sousa EMB (2008) Nanotechnology 19:185603 (7 pp)
Alvaro M, Aprile C, Garcia H, Gómez-García CJ (2006) Adv Funct Mater 16:1543–1548
Ma Z, Guan Y, Liu H (2006) J Magn Magn Mater 301:469–477
Chen FH, Gao Q, Ni JZ (2008) Nanotechnology 19:165103 (9 pp)
Guo H, Zhang X, Cui MH, Sharma R, Yang NL, Akins DL (2005) Mater Res Bull 40:1713–1725
Brunauer S, Emmett PH, Teller E (1938) J Am Chem Soc 60:309–319
Coey JMD, Cugat O, Mccauley J, Fabris JD (1992) Revista de Física Aplicada e Instrumentação 7:25–30
Holmes SM, Zholobenko VL, Thursfield A, Plaisted RJ, Cundy CS, Dwyer J (1998) J Chem Soc, Faraday Trans 94:2025–2032
Berubé F, Kaliaguine S (2008) Microporous Mesoporous Mater 115:469–479
Arruebo M, Galán M, Navascués N, Téllez C, Marquina C, Ibarra MR, Santamaría J (2006) Chem Mater 18:1911–1919
Birsan C, Predoi D, Andronescu E (2007) J Optoelectron Adv Mater 9:1821–1824
Zhao D, Feng J, Huo Q, Melosh N, Fredrickson GH, Chmelka BF, Stucky GD (1998) Science 279:548–552
Du Y, Liu S, Ji Y, Zhang Y, Liu F, Gao Q, Xiao FS (2008) Catal Today 131:70–75
Kim DH, Nikles DE, Johnson DT, Brazel CS (2008) J Magn Magn Mater 320:2390–2396
Bae S, Lee SW, Hirukawa A, Takemura Y, Jo YH, Lee SG (2009) IEEE Trans Nanotechnol 8:86–94
Acknowledgments
This work has been supported by CAPES, CNPq, FAPEMIG and LNLS (Campinas, Brazil).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Souza, K.C., Mohallem, N.D.S. & Sousa, E.M.B. Mesoporous silica-magnetite nanocomposite: facile synthesis route for application in hyperthermia. J Sol-Gel Sci Technol 53, 418–427 (2010). https://doi.org/10.1007/s10971-009-2115-y
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10971-009-2115-y