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Copolymers of pyrrole and N-(hydroxypropyl)pyrrole: properties and interaction with DNA

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Abstract

Copolymers derived from mixtures of pyrrole and N-(hydroxypropyl)pyrrole have been prepared electrochemically using various concentration ratios. Copolymers were generated on stainless electrodes by chronoamperometry and cyclic voltammetry in a LiClO4 acetonitrile solution. Relevant physical (density and doping level) and electrochemical (electroactivity and electrostability) properties of the copolymers have been examined and compared with those of the two corresponding homopolymers, which were prepared using the same electrochemical procedures. Results show that the copolymer obtained using the 25:75 N-(hydroxypropyl)pyrrole:pyrrole molar ratio presents an interesting behavior. Finally, the ability of the latter copolymer to form specific interactions with plasmid DNA has been compared with that of polypyrrole.

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Acknowledgements

This work was supported by MEC and FEDER funds with Grant MAT2006-04029. PP acknowledges the fellowship given by the Generalitat de Catalunya (DURSI). Dr. Luis J. del Valle acknowledges the pWL102 plasmid clone given by WF Doolittle (Dalhousie University, Canada).

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Authors and Affiliations

  1. Departament d’Enginyeria Química, E. T. S. d’Enginyers Industrials de Barcelona, Universitat Politècnica de Catalunya, Diagonal 647, 08028, Barcelona, Spain

    Peter Pfeiffer, Elaine Armelin & Carlos Alemán

  2. Unitat de Química Industrial, Escola Universitaria d’Enginyeria Técnica Industrial de Barcelona, Universitat Politécnica de Catalunya, Comte d’Urgell 187, 08036, Barcelona, Spain

    Francesc Estrany & Luis del Valle

  3. Departament d’Enginyeria Agroalimentària i Biotecnología, ESAB, Universitat Politècnica de Catalunya, Av Canal Olímpic s/n, 08860-Castelldefels, Barcelona, Spain

    Luis del Valle

  4. Organic Electrochemistry Laboratory, Universidade do Vale do Paraíba, Av. Shisima Hifumi 2911, São José dos Campos, CEP 12244-000, Brazil

    Liu Yao Cho

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  1. Peter Pfeiffer
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  2. Elaine Armelin
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  3. Francesc Estrany
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  4. Luis del Valle
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  5. Liu Yao Cho
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  6. Carlos Alemán
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Correspondence to Elaine Armelin or Carlos Alemán.

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Pfeiffer, P., Armelin, E., Estrany, F. et al. Copolymers of pyrrole and N-(hydroxypropyl)pyrrole: properties and interaction with DNA. J Polym Res 15, 225–234 (2008). https://doi.org/10.1007/s10965-007-9162-2

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  • DOI: https://doi.org/10.1007/s10965-007-9162-2

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