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Recent Advances in Iron Oxide Nanoparticles (IONPs): Synthesis and Surface Modification for Biomedical Applications

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Abstract

In recent years, extensive researches were devoted to iron oxide nanoparticles (IONPs), including magnetite (Fe3O4) and maghemite (γ-Fe2O3), due to their low toxicity and cost, in addition to their unique physicochemical and magnetic properties. In this review, we present a brief introduction on IONPs in terms of classification and properties. Because the synthesis approach and surface modification are found to be key factors for better control of particle morphology and shape, as well as to produce monodispersed IONPs, which have direct influence on their properties and applications, particular emphasis will be given to the chemical synthesis methods and surface modifications by several organic materials such as polyvinylpyrrolidone (PVP), chitosan, and cetyltrimethylammonium bromide (CTAB). Recent trends and future prospects in this research field are also discussed.

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Funding

The authors thoroughly acknowledged the Ministry of Higher Education (MOHE) and Universiti Sains Malaysia through FRGS Grant 203/PFIZIK/6763003 for the full support of this research work.

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  1. Nano-Biotechnology Research and Innovation (NanoBRI), Universiti Sains Malaysia, Institute for Research in Molecular Medicine (INFORMM), 11800, Pulau Pinang, Malaysia

    Osama Abu Noqta, Azlan Abdul Aziz & Ibrahim Adamu Usman

  2. Nano-Optoelectronic Research and Technology Lab (NORLab), School of Physics, Universiti Sains Malaysia, 11800, Pulau Pinang, Malaysia

    Osama Abu Noqta, Azlan Abdul Aziz & Ibrahim Adamu Usman

  3. Department of Physics, College of Science, University of Bahrain, Zallaq, Kingdom of Bahrain

    M. Bououdina

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  1. Osama Abu Noqta
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  2. Azlan Abdul Aziz
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Correspondence to Osama Abu Noqta or Azlan Abdul Aziz.

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Noqta, O.A., Aziz, A.A., Usman, I.A. et al. Recent Advances in Iron Oxide Nanoparticles (IONPs): Synthesis and Surface Modification for Biomedical Applications. J Supercond Nov Magn 32, 779–795 (2019). https://doi.org/10.1007/s10948-018-4939-6

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