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Application of DSC and NIRS to study the compatibility of metronidazole with different pharmaceutical excipients

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Abstract

The purpose of the present work was to study the compatibility of metronidazole with different pharmaceutical excipients (hydroxypropyl methylcellulose, poly(ethylene oxide), microcrystalline cellulose, dicalcium phosphate dihydrate, and anhydrous dicalcium phosphate) using differential scanning calorimetry and diffuse reflectance spectroscopy. Dicalcium phosphate dihydrate was the only excipient that showed interaction with metronidazole even before storage. Changes referring to a possible transition to dihydrate form were observed in the thermal curves of anhydrous dicalcium phosphate after four weeks of storage. Although dicalcium phosphate dihydrate can be replaced by the anhydrous form in pharmaceutical formulations, the observed transition might negatively influence the stability of dosage forms.

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Authors and Affiliations

  1. University Pharmacy, Department of Pharmacy Administration, Semmelweis University, Budapest, Hungary, 1092, Hőgyes E. u. 7–9

    Kiss D. & Zelkó R.

  2. Research Group of Technical Analytical Chemistry, Hungarian Academy of Sciences, Budapest University of Technology and Economics, Budapest, Hungary, 1111, Szt. Gellért tér 4

    Novák Cs.

  3. Institute of General and Analytical Chemistry, University of Technology and Economics, Budapest, Hungary, 1111, Szt. Gellért tér 4

    Éhen Zs.

Authors
  1. Kiss D.
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  2. Zelkó R.
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  3. Novák Cs.
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  4. Éhen Zs.
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Correspondence to Zelkó R..

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Kiss, D., Zelkó, R., Novák, C. et al. Application of DSC and NIRS to study the compatibility of metronidazole with different pharmaceutical excipients. J Therm Anal Calorim 84, 447–451 (2006). https://doi.org/10.1007/s10943-005-7257-9

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  • DOI: https://doi.org/10.1007/s10943-005-7257-9

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