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Design of gelatin nanoparticles as swelling controlled delivery system for chloroquine phosphate

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Abstract

Gelatin nanoparticles were prepared by a single W/O emulsion technique and characterized by infrared (IR) spectra, scanning electron microscopy (SEM) and particle size analysis. The prepared nanoparticles were loaded with chloroquine phosphate (CP), a well known antimalarial drug, and the release dynamics of entrapped drug was investigated as a function of various experimental factors such as percent loading of the drug, chemical architecture of the nanocarriers, and pH, temperature, ionic strength and nature of the release medium. The nanoparticles were also studied for their water sorption capacity by optical microscopic method taking advantage of the aggregation of nanoparticles. The drug release processes was analyzed kinetically using Ficks power law and a correlation was established between the quantity of released drug and swelling of the nanoparticles.

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  1. Bose Memorial Research Laboratory, Department of Chemistry, Government Autonomous Science College, Jabalpur, M.P., 482 001, India

    A. K. Bajpai & Jyoti Choubey

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  1. A. K. Bajpai
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  2. Jyoti Choubey
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Correspondence to A. K. Bajpai.

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Bajpai, A.K., Choubey, J. Design of gelatin nanoparticles as swelling controlled delivery system for chloroquine phosphate. J Mater Sci: Mater Med 17, 345–358 (2006). https://doi.org/10.1007/s10856-006-8235-9

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  • DOI: https://doi.org/10.1007/s10856-006-8235-9

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