Abstract
A novel hydrogel was prepared by crosslinking hyaluronan with glycol chitosan in aqueous solution using water soluble carbodiimide at nearly neutral pH and room temperature. The products can be easily formulated into injectable gels, various films, membranes and sponges for soft tissue augmentation, viscosupplementation, drug delivery, preventing adhesion of post operation, wound dressing and tissue engineering scaffolds. The said hydrogel has high water adsorption property and biostability. Rheololgical results of the gel showed a soft and viscoelastic structure. FTIR further confirmed the formation of amide bonds between carboxyl groups of hyaluronan and amine groups of glycol chitosan and no N-acylurea and other derivatives were identified.
Similar content being viewed by others
References
G. D. PRESTWICK, D. M.MARECEK, J. F.MARECEK, K. P. VERCRUYSEe and M. R.ZIEBLL, in “The Chemistry, Biology and Medical Applications of Hyaluronan and Its Derivatives,” edited by T. C. LAURENT (Portland Press Ltd, London, 1998).
J. R. E. FRASER, T. C. LAURENT and U.B.G. LAURENT, J. Int. Med. 242 (1997) 27.
A. P. SCLAFANI and T. ROMO, Facial Plastic Surgery 16 (2000) 29.
K.TOMIHATA and Y. IKADA, J. Biomed. Mater. Res. 37 (1997) 243.
E. Bell, Tissue Eng. 1 (1995) 163.
E. A. BALAZES and A. LESHCHINER, US Patent 4582865, 1986.
E. A. BALAZS, A. LESHCHINER and P. BAND, US Patent 4713448, 1987.
T. LAURENT, K. HELLSING and B. GELOTTE, Acta Chem. Scand. 18 (1964) 274.
T. MAELSON and D. B. A. NORMAN, WO 86/00912, 1986.
F. DELLA VALLE and A. ROMEO, US Patent 5676964, 1997.
W. RHEE and R. A. BERG, US Patent 5510121, 1996.
Y. LUO and G. D. PRESTWICH, J. Controlled Release, 69 (2000) 169.
J.-W. KUO, D. A. SWANN and G. D. PRESTWICH, Bioconjugate Chem. 2 (1991) 232.
J.-W. KUO, D. A. SWANN, A. DAVID and G.D. PRESTWICH, US Patent 6537979, 2003.
R. HAMILTON, E. M. FOX, R. A. ACHARYA, A. RAKSHA and A. E. WALTS, US Patent 4937270, 1990.
P. BULPITT and D AESCHLIMANN, J. Biomed. Mate. Res, 47 (1999) 152.
K.SHINODA and A. NAKAJIMA, Bull. Inst. Chem. Res. 53 (1975) 400.
A. NAKAJIMA and K. SHINODA, J. Appl. Polymer Sci. 21 (2003) 1249.
L. MARTIN, K. F. WILSON, C.G, SENELS and I. F. UCHEGBU, J. Control. Rel. 80 (2002) 87.
T. BITTER and H. M. MUIR, Analytical Biochem. 4 (1962) 330.
T. IMOTO and K. YAGISHITA, Agric. Biol. Chem. 35 (1971) 1154.
K. KURITA, H. YOSHINO, S-I. NISHIMURA and S. ISHII, Carbohydrate Polym. 20 (1993) 239.
W. WANG, S. BO and W. QIN, Int. J. Biolog. Macromolecules 3 (1991) 281.
A. DENUZIERE, D. FERRIER and A DOMARD, Carbohydrate polym. 29 (1996) 317.
J.-Y. LEE, J-H. KIM and K.-B. HAN, WO.02.30990, 2002.
J. W. BURNS, R. MILLER and A. E. WALTS, US Patent 5527893, 1996.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Wang, W. A novel hydrogel crosslinked hyaluronan with glycol chitosan. J Mater Sci: Mater Med 17, 1259–1265 (2006). https://doi.org/10.1007/s10856-006-0600-1
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/s10856-006-0600-1