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Implantable microdevice for peripheral nerve regeneration: materials and fabrications

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Abstract

Rapid innovations in tissue engineering have increased the likelihood that fabricated microdevices for neuro-regeneration can finally be applied to humans. The advent of microdevices has created strong interest in many fields, including diagnostics, drug/gene delivery, and tissue engineering. The integration of microfluidics and tissue engineering is believed to hold promise in applications for neuro-regeneration. Early clinical results suggest that the fabrication of microdevices with appropriate properties indeed yields multi-functional applications with enhanced efficacy and less adverse effects. A prerequisite for advancing this area of research is the development of apt devices for nerve restoration, which can provide molecular, electrical, and micro-environmental cues for efficient neuronal cell regeneration. Based on the increasing clinical application of fabrication methods and continued efforts to advance this technology, it is likely that microdevice fabrication will become an effective method for achieving the above-mentioned criteria. Therefore, the aim of this review is to provide basic information on the fabrication of microdevices by focusing exclusively on several kinds of biomaterials, such as biocompatible, biodegradable, non-conducting, conducing, elastomeric and thermoplastic materials with natural, synthetic polymers, inorganic biomaterials, and physiochemical parameter for neuro-regeneration. We also discuss distinctive nerve growth factors and neural cell types within the context of developing micro-based neuro-degenerative applications. The information provided in this review is important with regards to the safe and widespread use of microdevice fabrication, particularly in the neuro-regenerative field.

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References

  1. Evans GRD (2001) Anat Rec 263:396

    Article  CAS  Google Scholar 

  2. Grace NL, Eng M, Hoffman-Kim D (2008) Tissue Eng B 14:33

    Article  Google Scholar 

  3. Zhanga N, Yanb H, Wena X (2005) Brain Res Rev 49:48

    Article  CAS  Google Scholar 

  4. Chalfoun CT, Wirth GA, Evans GRD (2006) J Cell Mol Med 10:309

    Article  CAS  Google Scholar 

  5. Fry EJ (2001) Clin Exp Pharmacol Physiol 28:253

    Article  CAS  Google Scholar 

  6. Allen PB, Chiu DT (2008) Biochim Biophys Acta 1782:326

    CAS  Google Scholar 

  7. Ledeen R (1985) Trends Neurosci 8:169

    Article  CAS  Google Scholar 

  8. Molander-Melin M, Kaj B, Nenad B, Birgitta D, Jan-Eric M, Pam F (2005) J Neurochem 92:171

    Article  CAS  Google Scholar 

  9. Svennerholm L, Rynmark BM, Vilbergsson G, Fredman P, Gottfries J, Mansson JE, Percy A (1991) J Neurochem 56:1763

    Article  CAS  Google Scholar 

  10. Svennerholm L, Bostrom K, Jungbjer B, Olsson L (1994) J Neurochem 63:1802

    Article  CAS  Google Scholar 

  11. Kwak DH, Kim SM, Lee DH, Kim JS, Kim SM, Lee SU, Jung KY, Seo BB, Choo YK (2005) Mol Cells 20:354

    CAS  Google Scholar 

  12. Meek MF, Coert JH (2002) J Reconstr Microsurg 18:97

    Article  CAS  Google Scholar 

  13. Faweett JW, Keynes RJ (1990) Annu Rev Neurosci 13:43

    Article  Google Scholar 

  14. McFarlane S (2003) Neuron 37:559

    Article  CAS  Google Scholar 

  15. Derek NA, Edmund YCK, Claire LH, Mark DD, Wei-Shou Paul LHC (2005) J Neurobiol 62:134

    Article  CAS  Google Scholar 

  16. Daniel MS, Paul F (2000) J Neurobiol 44:97

    Article  Google Scholar 

  17. Walsh JF, Manwaring ME, Tresco PA (2005) Tissue Eng 11:1085

    Article  CAS  Google Scholar 

  18. Dowell-Mesfin NM, Abdul-Karim MA, Turner PAM, Schanz S, Craighead HG, Roysam B, Turner JN, Shain W (2004) J Neural Eng 1:78

    Article  CAS  Google Scholar 

  19. Cai J, Peng X, Nelson KD, Eberhart R, Smith GM (2005) J Biomed Mater Res A 75:374

    Google Scholar 

  20. Michael EM, Ennifer FWJ, Patrick AT (2004) Biomaterials 25:3631

    Article  CAS  Google Scholar 

  21. McCaig CD, Rajnicek AM, Song B, Zhao M (2002) Trends Neurosci 25:354

    Article  CAS  Google Scholar 

  22. Abu-Rub M, McMahon S, Zeugolis DI, Windebank A, Pandit A (2010) Drug Discov Today 15:436

    Article  CAS  Google Scholar 

  23. Lili M, Qun R, Anne-Marie D, Norton HN, Maria H (2005) Brain Res 1054:125

    Article  CAS  Google Scholar 

  24. Mocchetti I (2005) Cell Mol Life Sci 62:2283

    Article  CAS  Google Scholar 

  25. Kim YT, Kailash K, Sajal C, Dave DP (2009) Lab Chip 9:2576

    Article  CAS  Google Scholar 

  26. Schwab K, Arlett J, Worlock J, Roukes M (2000) Lett Nat 404:974

    Article  CAS  Google Scholar 

  27. Whitesides GM (2006) Nature 442:368

    Article  CAS  Google Scholar 

  28. Manz A, Harrison DJ, Verpoorte JEM, Fettinger JC, Paulus A, Ludi H, Widmer HM (1992) J Chromatogr 59:253

    Article  Google Scholar 

  29. Xia Y, Whitesides GM (1998) Annu Rev Mater Sci 28:153

    Article  CAS  Google Scholar 

  30. Terry SC, Jerman JH, Angell JB (1979) IEEE Trans Electron Dev 26:1880

    Article  Google Scholar 

  31. Li JN, Baskaran H, Dertinger SK, Whitesides GM, Van de Water L, Toner M (2002) Nat Biotechnol 20:826

    Article  CAS  Google Scholar 

  32. Tourovskaia A, Masot XF, Folch A (2005) Lab Chip 5:14

    Article  CAS  Google Scholar 

  33. Chung BG, Flanagan LA, Rhee SW, Schwartz PH, Lee AP, Monuki ES, Jeon NL (2005) Lab Chip 5:401

    Article  CAS  Google Scholar 

  34. Xu X, Yee W, Hwang P, Yu H, Wan C, Gao S, Boon K, Mao H, Leong K, Wang S (2003) Biomaterials 24:2405

    Article  CAS  Google Scholar 

  35. Vadim S, Polikov A, Patrick A, Tresco B, Reicherta WM (2005) J Neurosci Methods 148:1

    Article  Google Scholar 

  36. Rousche PJ, Pellinen DS, Pivin DP, Williams JC, Vetter RJ, Kipke DR (2001) IEEE Trans Biomed Eng 48:361

    Article  CAS  Google Scholar 

  37. Mandemakers W, Zwart R, Jaegle M, Walbeehm E, Visser P, Grosveld F, Meijer D (2000) EMBO J 19:2992

    Article  CAS  Google Scholar 

  38. Hakomori S, Handa K (2003) Methods Enzymol 363:191

    Article  CAS  Google Scholar 

  39. Joanne WC, Li X, Lin B, Shim S, Ming GL, Levchenko A (2008) Lab Chip 8:227

    Article  CAS  Google Scholar 

  40. Marimuthu M, Kim S (2009) Curr Nanosci 5:189

    Article  CAS  Google Scholar 

  41. Richardson TP, Peters MC, Ennett AB, Mooney DJ (2001) Nat Biotechnol 19:1029

    Article  CAS  Google Scholar 

  42. Bettinger CJ, Cyr KM, Matsumoto A, Langer R, Borenstein JT, Kaplan DL (2007) Adv Mater 19:2847

    Article  CAS  Google Scholar 

  43. Bettinger CJ, Weinberg EJ, Kulig KM, Vacanti JP, Wang Y, Borenstein JT, Langer R (2005) Adv Mater 18:165

    Article  CAS  Google Scholar 

  44. Taylor AM, Rhee SW, Tu CH, Cribbs DH, Cotman CW, Jeon NL (2003) Langmuir 19:1551

    Article  CAS  Google Scholar 

  45. McDonald JC, Whitesides GM (2002) Accounts Chem Res 35:491

    Article  CAS  Google Scholar 

  46. Jeong WP, Behrad V, Anne MT, Seog WR, Noo LJ (2006) Nat Protoc 1:2128

    Article  CAS  Google Scholar 

  47. Vasconcelos BC, Gay-Escoda C (2000) J Oral Maxillofac Surg 58:1257

    Article  CAS  Google Scholar 

  48. McDonald JC, Duffy DC, Anderson JR, Chiu DT, Wu H, Schueller OJ, Whitesides GM (2000) Electrophoresis 21:27

    Article  CAS  Google Scholar 

  49. David CD, McDonald JC, Olivier ASJ, George MW (1998) Anal Chem 70:4974

    Article  Google Scholar 

  50. De Silva MN, Desai R, Odde DJ (2004) Biomed Microdevices 6:219

    Article  Google Scholar 

  51. Peterson SL, McDonald A, Gourley PL, Sasaki DY (2005) J Biomed Mater Res A 72A:10

    Article  CAS  Google Scholar 

  52. Yang IH, Co CC, Ho CC (2005) Biomaterials 26:6599

    Article  CAS  Google Scholar 

  53. Minteer SD (2006) Microfluidic techniques: reviews and protocol. Humana Press, Totowa, NJ

    Google Scholar 

  54. Kato-Negishi M, Tsuda Y, Onoe H, Takeuchi S (2010) Biomaterials 31:8939

    Article  CAS  Google Scholar 

  55. Anne MT, Mathew BJ, Seog WR, David HC, Carl WC, Noo LJ (2005) Nat Methods 2:599

    Article  Google Scholar 

  56. Dertinger SKW, Jiang XY, Li ZY, Murthy VN, Whitesides GM (2002) Proc Natl Acad Sci USA 99:12542

    Article  CAS  Google Scholar 

  57. Wilson CJ, Clegg RE, Leavesley DI, Pearcy MJ (2005) Tissue Eng 11:1

    Article  CAS  Google Scholar 

  58. Gross PG, Kartalov EP, Scherer A, Weinerd LP (2007) J Neurol Sci 252:135

    Article  Google Scholar 

  59. King KR, Wang CCJ, Kaazempur-Mofrad MR, Vacanti JP, Borenstein JT (2004) Adv Mater 16:2007

    Article  CAS  Google Scholar 

  60. Khademhosseini A, Langer R, Borenstein J, Vacanti JP (2006) Proc Natl Acad Sci USA 103:2480

    Article  CAS  Google Scholar 

  61. Fukuda J, Khademhosseini A, Yeo Y, Yang X, Yeh J, Eng G (2006) Biomaterials 27:5259

    Article  CAS  Google Scholar 

  62. Hwang YS, Chung BG, Ortmann D, Hattori N, Moeller HC, Khademhosseini A (2009) Proc Natl Acad Sci USA 106:16978

    Article  CAS  Google Scholar 

  63. Kanemaru K, Okubo Y, Hirose K, Iino M (2007) J Neurosci 27:8957

    Article  CAS  Google Scholar 

  64. PD LeR, Reh TA (1994) J Neurosci 14:4639

    Google Scholar 

  65. Crone SA, Lee KF (2002) Neuron 36:333

    Article  CAS  Google Scholar 

  66. Maeda E, Robinson HP, Kawana A (1995) J Neurosci 15:34

    Google Scholar 

  67. Opitz T, De Lima AD, Voigt T (2002) J Neurophysiol 88:2196

    Article  CAS  Google Scholar 

  68. Voigt T, Baier H, Dolabela de LA (1997) Eur J Neurosci 9:990

    Article  CAS  Google Scholar 

  69. Wang W, Liu X, Xie Y, Zhang H, Yu W, Xiong Y, Xie W, Ma X (2006) J Mater Chem 16:3252

    Article  CAS  Google Scholar 

  70. Wang S, Wan ACA, Xu X, Gao S, Mao H, Leong KW, Yu H (2001) Biomaterials 22:1157

    Article  CAS  Google Scholar 

  71. Whitworth IH, Brown RA, Dore C, Green CJ, Terenghi G (2005) J Hand Surg 20B:429

    Google Scholar 

  72. Malm T, Bowald S, Bylock A, Busch C, Saldeen T (1994) Eur Surg Res 26:298

    Article  CAS  Google Scholar 

  73. Hazari A, Johansson-Ruden G, Junemo-Bostrom K, Ljungberg C, Terenghi G, Green C, Wiberg M (1999) J Hand Surg Br 24:291

    Article  CAS  Google Scholar 

  74. Hazari A, Wiberg M, Johansson-Ruden G, Green C, Terenghi G (1999) Br J Plast Surg 52:653

    Article  CAS  Google Scholar 

  75. Den Dunnen WF, Van der Lei B, Robinson PH, Holwerda A, Pennings AJ, Schakenraad JM (1995) J Biomed Mater Res 29:757

    Article  CAS  Google Scholar 

  76. Richards M, Dahiyat BI, Arm DM, Brown PR, Leong KW (1991) J Biomed Mater Res 25:1151

    Article  CAS  Google Scholar 

  77. Masuda T, Miwa Y, Tamagawa A, Mukai SR, Hashimoto K, Ikeda Y (1997) Polym Degrad Stabil 58:315

    Article  CAS  Google Scholar 

  78. Arunas R, Asta K, Almira R (2005) Sensor Actuators B 111–112:532

    Google Scholar 

  79. Abidian MR, Corey JM, Kipke DR, Martin DC (2010) Small 6:421

    Article  CAS  Google Scholar 

  80. Zelikin AN, Lynn DM, Farhadi J, Martin I, Shastri V, Langer R (2002) Angew Chem Int Ed 41:141

    Article  CAS  Google Scholar 

  81. Guixin S, Mahmoud R, Zhaoxu W, Daoc LH, Ze Z (2004) Biomaterials 25:2477

    Article  CAS  Google Scholar 

  82. Guimard NK, Sessler JL, Schmidt CE (2007) Mater Res Soc Symp Proc 950:99

    Google Scholar 

  83. Kamalesh S, Tan P, Wang J, Lee T, Kang ET, Wang CH (2000) J Biomed Mater Res 52:467

    Article  CAS  Google Scholar 

  84. Cao Y, Croll TI, Cooper-White JJ, O’ Connor AJ, Stevens GW (2003) Biopolym Methods Tissue Eng 238:87

    Article  Google Scholar 

  85. Wang YC, Lin MC, Wang DM, Hsieh HJ (2003) Biomaterials 24:1047

    Article  CAS  Google Scholar 

  86. Williams JM, Adewunmi A, Schek RM, Flanagan CL, Krebsbach PH, Feinberg SE, Hollister SJ, Das S (2005) Biomaterials 26:4817

    Article  CAS  Google Scholar 

  87. Sahoo SK, Panda AK, Labhasetwar V (2005) Biomacromolecules 6:1132

    Article  CAS  Google Scholar 

  88. Leach JB, Bivens KA, Patrick Jr CW, Schmidt CE (2003) Biotechnol Bioeng 82:578

    Article  CAS  Google Scholar 

  89. Rutishauser U (1993) Curr Opin Neurobiol 3:709

    Article  CAS  Google Scholar 

  90. Chen YS, Hsieh CL, Tsai CC, Chen TH, Cheng WC (2000) Biomaterials 21:1541

    Article  CAS  Google Scholar 

  91. Hudson TW, Evans GR, Schmidt CE (1999) Clin Plast Surg 26:617

    CAS  Google Scholar 

  92. Gomez N, Schmidt CE (2007) J Biomed Mater Res A 81:135

    Google Scholar 

  93. Sanghvi AB, Miller KP, Belcher AM, Schmidt CE (2005) Nat Mater 4:496

    Article  CAS  Google Scholar 

  94. Wang Z, Roberge C, Dao LH, Wan Y, Shi G, Rouabhia M, Guidoin R, Zhang Z (2004) J Biomed Mater Res 70:28

    Article  CAS  Google Scholar 

  95. Feng Z, Zhilu L, Bo Y, Miao C, Jingcheng H, Weimin L, Qunji X (2004) Surf Sci 561:1

    Article  CAS  Google Scholar 

  96. Rivers TJ, Hudson TW, Schmidt CE (2002) Adv Funct Mater 12:33

    Article  CAS  Google Scholar 

  97. Galit S, Mariusz G, Stanislaw S, Abraham JD, Daniel M (2007) New J Chem 31:163

    Article  CAS  Google Scholar 

  98. Bettinger CJ, Bruggeman JP, Borenstein JT, Langer RS (2008) Biomaterials 29:2315

    Article  CAS  Google Scholar 

  99. Bettinger CJ, Bao Z (2010) Adv Mater 22(5):651

    Article  CAS  Google Scholar 

  100. Irimia-Vladu M, Troshin PA, Reisinger M, Shmygleva L, Kanbur Y, Schwabegger G, Bodea M, Schwödiauer R, Mumyatov A, Fergus JW, Razumov VF, Sitter H, Sariciftci NS, Bauer S (2010) Adv Funct Mater 20:4069

    Article  CAS  Google Scholar 

  101. Wong JY, Langer R, Ingber DE (1994) Proc Natl Acad Sci USA 91:3201

    Article  CAS  Google Scholar 

  102. Rozsnyai LF, Wrighton MS (1995) Langmuir 11:3913

    Article  CAS  Google Scholar 

  103. Zhang Z, Yoo R, Wells M, Beebe TP, Biran R, Trescob P (2005) Biomaterials 26:47

    Article  CAS  Google Scholar 

  104. Song HK, Toste B, Ahmann K, Hoffman-Kim D, Palmore GT (2006) Biomaterials 27:473

    Article  CAS  Google Scholar 

  105. Yang J, Webb AR, Ameer GA (2004) Adv Mater 16:511

    Article  CAS  Google Scholar 

  106. Diaz AF, Hall B (1983) IBM J Res Dev 27:342

    Article  CAS  Google Scholar 

  107. Machado JM, Masse MA, Karasz FE (1989) Polymer 30:1992

    Article  CAS  Google Scholar 

  108. Otero TF, Sansihena JM (1997) Bioelectrochem Bioenerg 42:117

    Article  CAS  Google Scholar 

  109. Wu X, Tian-An C, Rieke RD (1996) Macromolecules 29:7671

    Article  CAS  Google Scholar 

  110. Wang Y, Ameer GA, Sheppard BJ, Langer R (2002) Nat Biotechnol 20:602

    Article  CAS  Google Scholar 

  111. Bruggeman JP, Bettinger CJ, Nijst CLE, Kohane DS, Langer R (2008) Adv Mater 20:1922

    Article  CAS  Google Scholar 

  112. Guo XD, Zheng QX, Du JY, Yang SH, Wang H, Shao ZW, Sun EJ (2002) J Wuhan Univ Technol 17:30

    CAS  Google Scholar 

  113. Lee JY, Bashur CA, Goldstein AS, Schmidt CE (2009) Biomaterials 30:4325

    Article  CAS  Google Scholar 

  114. Li X, Hou S, Feng X, Yu Y, Ma J, Li L (2009) Colloid Surface B 74:370

    Article  CAS  Google Scholar 

  115. Gorka O, Susan KT, Jose LP, Jean-Pierre H (2006) Biomaterials 27:3691

    Article  CAS  Google Scholar 

  116. Richardson-Burns SM, Hendricks JL, Brian F, Povlich LK, Dong-Hwan K, Martin DC (2007) Biomaterials 281:1539

    Article  CAS  Google Scholar 

  117. Jun SB, Hynd MR, Dowell-Mesfin N, Smith KL, Turner JN, Shain W (2007) J Neurosci Methods 160:317

    Article  CAS  Google Scholar 

  118. Humphries MJ, Travis MA, Clark K, Mould AP (2004) Biochem Soc Trans 32:822

    Article  CAS  Google Scholar 

  119. Tai BCU, Du C, Gao S, Wan ACA, Ying JY (2010) Biomaterials 31:48

    Article  CAS  Google Scholar 

  120. Sarkar S, Dadhania M, Rourke P, Desai TA, Wong JY (2007) Acta Biomater 1:93

    Article  Google Scholar 

  121. Webber MJ, Tongers J, Renault MA, Roncalli JG, Losordo DM, Stupp SI (2010) Acta Biomater 6:3–11

    Article  CAS  Google Scholar 

  122. Kawai K, Suzuki S, Tabata Y, Ikada Y, Nishimura Y (2000) Biomaterials 21:489

    Article  CAS  Google Scholar 

  123. Butler CE, Navarro FA, Orgill DP (2001) J Biomed Mater Res 58:75

    Article  CAS  Google Scholar 

  124. Sarkar S, Lee GY, Wong JY, Desai TA (2006) Biomaterials 27:4775

    Article  CAS  Google Scholar 

  125. Vozzi G, Flaim C, Ahluwalia A, Bhatia S (2003) Biomaterials 24:2533

    Article  CAS  Google Scholar 

  126. Gray KJ, Shenaq SM, Engelmann UH, Fishman IJ, Jeraj K, Spira M (1987) Plast Reconstr Surg 79:778

    Article  CAS  Google Scholar 

  127. Pringle JM, Forsyth M, MacFarlane DR, Wagner K, Hall SB, Officer DL (2005) Polymer 46:2047

    Article  CAS  Google Scholar 

  128. Borenstein JT, Terai H, King KR, Weinberg EJ, Kaazempur-Mofrad MR, Vacanti JP (2002) Biomed Microdevices 4:167

    Article  CAS  Google Scholar 

  129. Guimard NK, Gomez N, Schmidt CE (2007) Prog Polym Sci 32:876

    Article  CAS  Google Scholar 

  130. Luo Y, Shoichet MS (2004) Nat Mater 3:249

    Article  CAS  Google Scholar 

  131. Chamberlain LJ, Yannas IV, Hsu HP, Strichartz G, Spector M (1998) Exp Neurol 154:315

    Article  CAS  Google Scholar 

  132. Marimuthu M, Kim S, An J (2010) Soft Matter 6:2200

    Article  CAS  Google Scholar 

  133. Green RA, Lovell NH, Wallace GG, Poole-Warren LA (2008) Biomaterials 29:3393

    Article  CAS  Google Scholar 

  134. Green RA, Williams CM, Lovell NH, Poole-Warren LA (2008) J Mater Sci Mater Med 19:1625

    Article  CAS  Google Scholar 

  135. Silva GA (2006) Nat Rev Neurosci 7:65

    Article  CAS  Google Scholar 

  136. Dugan LL, Lovett EG, Quick KL, Lotharius J, Lin TT, O’Malley KL (2001) Parkinsonism Relat D 7:243

    Article  Google Scholar 

  137. Gizdavic-Nikolaidis M, Travas-Sejdic J, Graham AB, Ralph CP, Thompson C, Kilmartin PA (2004) Curr Appl Phys 4:347

    Article  Google Scholar 

  138. Ravichandran R, Sundarrajan S, Venugopal JR, Mukherjee S, Ramakrishna S (2010) J R Soc Interface 7:559

    Article  CAS  Google Scholar 

  139. Caruso MM, Davis DA, Shen Q, Odom SA, Sottos NR, White SW, Moore SJ (2009) Chem Rev 109:5755

    Article  CAS  Google Scholar 

  140. Pu LL, Syed SA, Reid M, Patwa H, Goldstein JM, Forman DL, Thomson JG (1999) Plast Reconstr Surg 104:1379

    Article  CAS  Google Scholar 

  141. Rodri guez FJ, Valero-Cabre A, Navarro X (2007) Drug Discov Today 1:177

    Google Scholar 

  142. Haile Y, Haastert K, Cesnulevicius K, Stummeyer K, Timmer M, Berski S, Dräger G, Gerardy-Schahn R, Grothe C (2007) Biomaterials 28:1163

    Article  CAS  Google Scholar 

  143. Willerth SM, Sakiyama-Elbert SE (2007) Adv Drug Deliv Rev 59:325

    Article  CAS  Google Scholar 

  144. Molander H, Olsson Y, Engkvist O, Bowald S, Eriksson I (1982) Muscle Nerve 5:54

    Article  CAS  Google Scholar 

  145. Vergara C, Ramirez B (2004) Brain Res Rev 47:161

    Article  CAS  Google Scholar 

  146. Parrinello S, Napoli I, Ribeiro S, Digby PW, Fedorova M, Parkinson DB, DS DoddrellR, Nakayama M, Adams RH, Lloyd AC (2010) Cell 143:145

    Article  CAS  Google Scholar 

  147. Wittig JH, Ryan AF, Asbeck PM (2005) J Neurosci Methods 144:79

    Article  Google Scholar 

  148. Rosenthal A, Macdonald A, Voldman J (2007) Biomaterials 28:3208

    Article  CAS  Google Scholar 

  149. McDonald JW, Liu XZ, Qu Y, Liu S, Mickey SK, Turetsky D, Gottlieb DI, Choi DW (1999) Nat Med 5:1410

    Article  CAS  Google Scholar 

  150. Chen FM, Shelton RM, Jin Y, Chapple IL (2009) Med Res Rev 29:472

    Article  CAS  Google Scholar 

  151. Varkey M, Gittens SA, Uludag H (2004) Expert Opin Drug Deliv 1:19

    Article  CAS  Google Scholar 

  152. Anitua E, Sanchez M, Orive G, Andia I (2007) Biomaterials 28:4551

    Article  CAS  Google Scholar 

  153. Discher DE, Mooney DJ, Zandstra PW (2009) Science 324:1673

    Article  CAS  Google Scholar 

  154. Kaigler D, Cirelli JA, Giannobile WV (2006) Expert Opin Drug Deliv 3:647

    Article  CAS  Google Scholar 

  155. Herberg S, Siedler M, Pippig S, Schuetz A, Dony C, Kim CK (2008) J Clin Periodontol 35:976

    Article  CAS  Google Scholar 

  156. Higuchi T, Kinoshita A, Takahashi K, Oda S, Ishikawa I (1999) J Periodontol 70:1026

    Article  CAS  Google Scholar 

  157. Chen SJ, Wang DY, Yuan CW, Wang XD, Zhang P, Gu XS (2000) J Mater Sci Lett 19:2157

    Article  CAS  Google Scholar 

  158. George PM, Lyckman AW, Lavan DA, Hedge A, Leung Y, Avasare R, Testa C, Alexander PM, Langer R, Sur M (2005) Biomaterials 26:3511

    Article  CAS  Google Scholar 

  159. Cui X, Hetke JF, Wiler JA, Anderson DJ, Martin DC (2001) Sensor Actuators A 93:8

    Article  Google Scholar 

  160. Cui X, Wiler J, Dzaman M, Altschuler RA, Martin DC (2003) Biomaterials 24:777

    Article  CAS  Google Scholar 

  161. Kotwal A, Schmidt CE (2001) Biomaterials 22:1055

    Article  CAS  Google Scholar 

  162. Schmidt CE, Shastri VR, Vacanti JP, Langer R (1997) Proc Natl Acad Sci USA 94:8948

    Article  CAS  Google Scholar 

  163. Wang X, Gu X, Yuan C, Chen S, Zhang P, Zhang T, Yao J, Chen F, Chen G (2004) J Biomed Mater Res A 68:411

    Article  CAS  Google Scholar 

  164. Williams RL, Doherty PJ (1994) J Mater Sci Mater Med 5:429

    Article  CAS  Google Scholar 

  165. Prissanaroon W, Brack N, Pigram PJ, Hale P, Kappen P, Liesegang J (2005) Thin Solid Films 477:131

    Article  CAS  Google Scholar 

  166. Cen L, Neoh KG, Kang ET (2002) Langmuir 18:8633

    Article  CAS  Google Scholar 

  167. Chen G, Ito Y, Imanishi Y (1997) Biochim Biophys Acta 1358:200

    Article  CAS  Google Scholar 

  168. Zisch AH, Chenk U, Schense JC, Sakiyama-Elbert SE, Hubbel JA (2001) J Control Release 71:101

    Article  Google Scholar 

  169. Subbiah R, Veerapandian M, Yun K (2010) Curr Med Chem 17:4559

    Article  CAS  Google Scholar 

  170. Ducic I, Maloney CT, Dellon AL (2005) J Reconstr Microsurg 21:29

    Article  CAS  Google Scholar 

  171. Shin RH, Friedrich PF, Crum BA, Bishop AT, Shin AY (2009) J Bone Joint Surg Am 91:2194

    Article  Google Scholar 

  172. Yuen D, Jenssen JR, Rodriguez G, Li ST (2003) Trans Soc Biomater 228:228

    Google Scholar 

  173. Archibald SJ, Shefner J, Krarup C, Madison RD (1995) J Neurosci 15:4109

    CAS  Google Scholar 

  174. McDonald JW, Howard MJ (2002) Prog Brain Res 137:299

    Article  Google Scholar 

  175. Christine ES, Jennie BL (2003) Annu Rev Biomed Eng 5:293

    Article  CAS  Google Scholar 

  176. Heath CA, Rutkowski GE (1998) Trends Biotechnol 16:163

    Article  CAS  Google Scholar 

  177. Chiu DT, Janecka I, Krizek TJ, Wolff M, Lovelace RE (1982) Surgery 91:226

    CAS  Google Scholar 

  178. Walton RL, Brown RE, Matory WE, Borah GL, Dolph JL (1989) Plast Reconstr Surg 84:944

    Article  CAS  Google Scholar 

  179. Battiston B, Tos P, Cushway TR, Geuna S (2000) Microsurgery 20:32

    Article  CAS  Google Scholar 

  180. Karacaoglu E, Yuksel F, Peker F, Guler MM (2001) Microsurgery 21:196

    Article  CAS  Google Scholar 

  181. Brandt J, Dahlin LB, Lundborg G (1999) J Hand Surg Br 24:284

    Article  CAS  Google Scholar 

  182. Ide C, Tohyama K, Tajima K, Endoh K, Sano K (1998) Exp Neurol 154:99

    Article  CAS  Google Scholar 

  183. Ahmed Z, Brown AR (1999) Cell Motil Cytoskel 42:331

    Article  CAS  Google Scholar 

  184. Yoshii S, Oka M, Shima M, Taniguchi A, Akagi M (2002) Brain Res 949:202

    Article  CAS  Google Scholar 

  185. Kauppila T, Jyvasjarvi E, Huopaniemi T, Hujanen E, Liesi P (1993) Exp Neurol 123:181

    Article  CAS  Google Scholar 

  186. Seckel BR, Jones D, Hekimian KJ, Wang KK, Chakalis DP, Costas PD (1995) J Neurosci Res 40:318

    Article  CAS  Google Scholar 

  187. Herbert CB, Nagaswami C, Bittner GD, Hubbell JA, Weisel JW (1998) J Biomed Mater Res 40:551

    Article  CAS  Google Scholar 

  188. Ahmed Z, Underwood S, Brown RA (2000) Cell Motil Cytoskel 46:6

    Article  CAS  Google Scholar 

  189. Balgude AP, Yu X, Szymanski A, Bellamkonda RV (2001) Biomaterials 22:1077

    Article  CAS  Google Scholar 

  190. Hashimoto T, Suzuki Y, Kitada M, Kataoka K, Wu S, Suzuki K, Endo K, Nishimura Y, Ide C (2002) Exp Brain Res 146:356

    Article  CAS  Google Scholar 

  191. Evans GR, Brandt K, Katz S, Chauvin P, Otto L (2002) Biomaterials 23:841

    Article  CAS  Google Scholar 

  192. Dunnen WFA, Meek MF, Grijpma DW, Robinson PH, Schakenraad JM (2000) J Biomed Mater Res 51:575

    Article  Google Scholar 

  193. Soldani G, Varelli G, Dario P, Minnocci A (1998) Biomaterials 19:1919

    Article  CAS  Google Scholar 

  194. Aldini NN, Fini M, Rocca M, Giavaresi G, Giardino R (2000) Int Orthop 24:121

    Article  Google Scholar 

  195. Young RC, Wiberg M, Terenghi G (2002) Br J Plast Surg 55:235

    Article  CAS  Google Scholar 

  196. Lore AB, Hubbell JA, DS BobbJ, Ballinger ML, Loftin KL (1999) J Neurosci 19:2442

    CAS  Google Scholar 

  197. Lenihan DV, Carter AJ, Gilchrist T, Healy DM, Miller IA, Myles LM, Glasby MA (1998) J Hand Surg Br 23:588

    CAS  Google Scholar 

  198. Valentini RF, Vargo TG, Gardella JA, Aebischer P (1993) J Biomat Sci Polym E 5:13

    Article  CAS  Google Scholar 

  199. Alik SW, Jeffries-El M, Xinyan C, Lagenaur CF, Yoky M (2007) Biosens Bioelectron 22:1723

    Article  CAS  Google Scholar 

  200. Dahlin L, Lundborg G (2001) J Hand Surg Br 26:393

    Article  CAS  Google Scholar 

  201. Pitta MC, Wolford LM, Mehra P, Hopkin J (2001) J Oral Maxil Surg 59:493

    Article  CAS  Google Scholar 

  202. Kim DH, Abidan M, Martin DC (2004) J Biomed Mater Res A 71:577

    Article  CAS  Google Scholar 

  203. Rajesh R, Pandey SS, Takashima W, Kaneto K (2004) J Appl Polym Sci 93:927

    Article  CAS  Google Scholar 

  204. Huang Z, Wang PC, Feng J, MacDiarmid AG (1997) Synth Met 85:1375

    Article  CAS  Google Scholar 

  205. Huang Z, Wang PC, MacDiarmid AG (1997) Langmuir 13:6480

    Article  CAS  Google Scholar 

  206. Racicot R, Brown R, Yang SC (1997) Synth Met 85:1263

    Article  CAS  Google Scholar 

  207. Bo L, Suresh S, Lawrence S, Jeffries-EL M, Mihaela CI, Genevieve S, Jessica C, Rui Z, Joseph CR, Aaron GK, Jay LS, Tomasz K, Weiss EL, McCullough RD, Gary KF, David NL (2007) Sensor Actuators B 123:651

    Article  CAS  Google Scholar 

  208. Choi SJ, Kima TH, Shin YK, Lee CS, Park M, Lee HS, Song J (2008) Brain Res 1191:75

    Article  CAS  Google Scholar 

  209. Hiroshi Y, Kazuo A, Masatsugu S (2009) Synth Met 159:762

    Article  CAS  Google Scholar 

  210. Lada AG, Minino-Justelb P, Alois KS (2010) Wear 268:708

    Article  CAS  Google Scholar 

  211. Liaohai C, McBranch DW, Hsing-Lin W, Roger H, Fred W, David GW (1999) Proc Natl Acad Sci USA 96:12287

    Article  Google Scholar 

  212. Moliton A, Hiorns RC (2004) Polym Int 53:1397

    Article  CAS  Google Scholar 

  213. Opik A, Golovtsov I, Lobanov A, Kerm K (1993) Synth Met 57:4924

    Article  CAS  Google Scholar 

  214. Apiwat K, Janvikul W, Wichai U, Rutnakornpituk M (2008) Carbohydr Polym 74:257

    Article  CAS  Google Scholar 

  215. Hyeonseong B, Se YC, Young SY, Hyoung-Joon J (2010) Curr Appl Phys 10:S468

    Article  Google Scholar 

  216. Nambiar S, Yeow JTW (2011) Biosens Bioelectron 26:1825

    Article  CAS  Google Scholar 

  217. Mosconi T, Kruger L (1996) Pain 64:37

    Article  CAS  Google Scholar 

  218. Liu B, Ma J, Gao E, He Y, Cui F, Xu Q (2008) Biosens Bioelectron 23:1221

    Article  CAS  Google Scholar 

  219. Kraljic MR, Duic L (2006) Electrochim Acta 51:6045

    Article  CAS  Google Scholar 

  220. Lovinger A (1983) J Sci 220:1115

    Article  CAS  Google Scholar 

  221. Laizhou S, Zunju Z, Shizhe S, Zhiming G (2007) J Mater Sci Technol 23:55

    Article  CAS  Google Scholar 

  222. Zheng J, Zhu W, Wang D, An Y, Zhang W, Jin L (2008) Chin J Anal Chem 36:1316

    Article  CAS  Google Scholar 

  223. Sailor MJ, Curtis CL (1994) Adv Mater 6:688

    Article  CAS  Google Scholar 

  224. Abdelwahab NA, El-Nashar DE, Abd El-Ghaffar MA (2011) Mater Des 32:238

    Article  CAS  Google Scholar 

  225. Shah PN, Manthe RL, Lopina ST, Yun YH (2009) Polymer 50:2281

    Article  CAS  Google Scholar 

  226. Glenn CG, O’Leary ME, Hansen S, Sun JQ (2003) Appl Acoust 64:229

    Article  Google Scholar 

  227. Harper GP, Barde YA, Burnstock G, Carstairs JR, Dennison ME, Suda K, Vernon CA (1979) Nature 279:160

    Article  CAS  Google Scholar 

  228. Maisonpierre PC, Belluscio L, Squinto S, Ip NY, Furth ME, Lindsay RM, Yancopoulos GD (1990) Science 247:1446

    Article  CAS  Google Scholar 

  229. Grill R, Murai K, Blesch A, Gage FH, Tuszynski MH (1997) J Neurosci 17:5560

    CAS  Google Scholar 

  230. Patel M, Mao L, Wu B, VandeVord PJ (2007) J Tissue Eng Regen Med 1:360

    Article  CAS  Google Scholar 

  231. Yin Q, Kemp GJ, Yu LG, Wagstaff SC, Frostick SP (2001) Muscle Nerve 24:345

    Article  CAS  Google Scholar 

  232. Sahenk Z, Seharaseyon J, Mendell JR (1994) Brain Res 655:246

    Article  CAS  Google Scholar 

  233. Danielsen N, Pettmann B, Vahlsing HL, Manthorpe M, Varon S (1988) J Neurosci Res 320:330

    Google Scholar 

  234. Cordeiro PG, Seckel BR, Lipton SA, D’Amore PA, Wagner J, Madison R (1989) Plast Reconstr Surg 83:1013

    Article  CAS  Google Scholar 

  235. Logan A, Green J, Hunter A, Jackson R, Berry M (1999) Eur J Neurosci 11:2367

    Article  CAS  Google Scholar 

  236. Vogelin E, Baker JM, Gates J, Dixit V, Constantinescu MA, Jones NF (2006) Exp Neurol 199:348

    Article  CAS  Google Scholar 

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Acknowledgements

This research was supported by the Kyungwon University Research Fund in 2011 (KWU 2011-R081).

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  1. Department of Bionanotechnology, Kyungwon University, San 65, Bokjeong-Dong, Sujeong-Gu, Seongnam-Si, 461-701, Gyeonggi, Republic of Korea

    Devasier Bennet & Sanghyo Kim

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Correspondence to Sanghyo Kim.

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Bennet, D., Kim, S. Implantable microdevice for peripheral nerve regeneration: materials and fabrications. J Mater Sci 46, 4723–4740 (2011). https://doi.org/10.1007/s10853-011-5510-z

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