Skip to main content
SpringerLink
Log in

Supercritical CO2 processing of polymers for the production of materials with applications in tissue engineering and drug delivery

  • Published:
Journal of Materials Science Aims and scope Submit manuscript

Abstract

Supercritical carbon dioxide (SCCO2) was used for the preparation of foamed sponges and intermingled fibers of biopolymers with potential applications in tissue engineering and drug delivery. The work was focused on the processing of both biodegradable polylactic acid (l-PLA) and non-biodegradable polymethylmethacrylate (PMMA) homopolymers. Monolithic porous sponges of amorphous PMMA were prepared using SCCO2 as a porogen agent by simple swelling and foaming. Under similar experimental conditions, l-PLA was crystallized. The study also addresses the impregnation of biopolymers with an active agent dispersed in SCCO2. The drug used for impregnation was triflusal, a platelet antiaggregant inhibitor for thrombogenic cardiovascular diseases. Foaming often leads to a closed pore structure after depressurization which is disadvantageous for 3D scaffolds as it does not fulfill the requirement of interconnectivity necessary for cell migration. To overcome these drawbacks, fibers forming macroporous structures were prepared using a semicontinuous antisolvent (SAS) technique.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7

Similar content being viewed by others

References

  1. Hutmacher DW (2000) Biomaterials 21:2529

    Article  CAS  Google Scholar 

  2. Burg KJL, Porter S, Kellam JF (2000) Biomaterials 21:2347

    Article  CAS  Google Scholar 

  3. Shin H, Jo S, Mikos AG (2003) Biomaterials 24:4353

    Article  CAS  Google Scholar 

  4. Liu X, Ma PX (2004) Ann Biomed Eng 32(3):477

    Article  Google Scholar 

  5. Whang K, Thomas CH, Healy KE, Nuber G (1995) Polymer 36:837

    Article  CAS  Google Scholar 

  6. Zhang Y, Lim CT, Ramakrishna S, Huang Z-M (2005) J Mater Sci Mater Med 16:933

    Article  CAS  Google Scholar 

  7. Tuzlakoglu K, Bolgen N, Salgado AJ, Gomes ME, Piskin E, Reis RL (2005) J Mater Sci Mater Med 16:1099

    Article  CAS  Google Scholar 

  8. Cooper JA, Lu HH, Ko FK, Freeman JW, Laurencin CT (2005) Biomaterials 26:1523

    Article  CAS  Google Scholar 

  9. Chen VJ, Ma PX (2004) Biomaterials 25:2065

    Article  CAS  Google Scholar 

  10. Robinson JR, Lee VHL (1987) Controlled drug delivery: fundamentals and applications, 2nd edn. Marcel Dekker, New York

    Book  Google Scholar 

  11. Beckman EJ (2004) J Supercrit Fluids 28:121

    Article  CAS  Google Scholar 

  12. Tomasko DL, Li H, Liu D, Han X, Wingert MJ, Lee LJ, Koelling KW (2003) Ind Eng Chem Res 42:6431

    Article  CAS  Google Scholar 

  13. Cooper AI (2000) J Mater Chem 10:207

    Article  CAS  Google Scholar 

  14. Kazarian SG (2000) Polymer Sci Ser 42:78

    Google Scholar 

  15. Cooper AI (2003) Adv Mater 15:1049

    Article  CAS  Google Scholar 

  16. Mooney DJ, Baldwin DF, Suh NP, Vacanti JP, Langer R (1996) Biomaterials 17:1417

    Article  CAS  Google Scholar 

  17. Quirk RA, France RM, Shakesheff KM, Howdle SM (2004) Curr Opin Solid State Mater Sci 8:313

    Article  CAS  Google Scholar 

  18. Howdle SM, Watson MS, Whitaker MJ, Popov VK, Davies MC, Mandel FS, Don Wang J, Shakesheff KM (2001) Chem Commun 1:109

    Article  Google Scholar 

  19. Xu Q, Chang Y (2004) J Appl Polym Sci 93:742

    Article  CAS  Google Scholar 

  20. Perrut M, Jung J, Leboeuf F (2005) Int J Pharm 288:11

    Article  CAS  Google Scholar 

  21. Kazarian SG, Martirosyan GG (2002) Int J Pharm 232:81

    Article  CAS  Google Scholar 

  22. Sheridan MH, Shea LD, Peters MC, Mooney DJ (2000) J Control Release 64:91

    Article  CAS  Google Scholar 

  23. Kikic I, Vecchione F (2003) Curr Opin Solid State Mater Sci 7(4–5):399

    Article  CAS  Google Scholar 

  24. Woods HM, Silva MCG, Nouvel C, Shakesheff KM, Howdle SM (2004) J Mater Chem 14:1663

    Article  CAS  Google Scholar 

  25. Vega-González A, Domingo C, Elvira C, Subra P (2004) J Appl Polym Sci 91:2422

    Article  Google Scholar 

  26. Reverchon E, Antonacci A (2007) J Supercrit Fluids 39:444

    Article  CAS  Google Scholar 

  27. Thies J, Müller BW (1998) Eur J Pharm Biopharm 45:67

    Article  CAS  Google Scholar 

  28. Randolph TW, Randolph AD, Mebes M, Yeung S (1993) Biotechnol Prog 9:429

    Article  CAS  Google Scholar 

  29. Sproule TL, Lee JA, Li H, Lannutti JJ, Tomasko DL (2004) J Supercrit Fluids 28:241

    Article  CAS  Google Scholar 

  30. Elvira C, Fanovich A, Fernandez M, Fraile J, San Roman J, Domingo C (2004) J Control Release 99:231

    Article  CAS  Google Scholar 

  31. Muth O, Hirth Th, Vogel H (2000) J Supercrit Fluids 17:65

    Article  CAS  Google Scholar 

  32. Condo PD, Johnston KP (1992) Macromolecules 25:6730

    Article  CAS  Google Scholar 

  33. Üzer S, Akman U, Hortaçsu Ö (2006) J Supercrit Fluids 38:119

    Article  Google Scholar 

  34. Kazarian S, Vincent MF, Bright FV, Liotta CL, Eckert CA (1996) J Am Chem Soc 118:1729

    Article  CAS  Google Scholar 

  35. Wissinger RG, Paulatis ME (1987) J Polym Sci Part B Polym Phys 25:2497

    Article  CAS  Google Scholar 

  36. Pantoula M, Panayiotou C (2006) J Supercrit Fluids 37:254

    Article  CAS  Google Scholar 

  37. Goel SK, Beckman EJ (1994) Polym Eng Sci 34:1148

    Article  CAS  Google Scholar 

  38. Barry JJA, Gidda HS, Scotchford CA, Howdle SM (2004) Biomaterials 25:3559

    Article  CAS  Google Scholar 

  39. Krause B, Mettinkhof R, van der Vegt NFA, Wessling M (2001) Macromolecules 34:874

    Article  CAS  Google Scholar 

  40. Sheridan MH, Shea LD, Peters MC, Mooney DJ (2000) J Control Release 64:91

    Article  CAS  Google Scholar 

  41. Takada M, Hasegawa S, Ohshima M (2001) Polym Eng Sci 41:1938

    Article  CAS  Google Scholar 

  42. Fischer EW, Sterzel HJ, Wegner G (1973) Colloid Polym Sci 251:1980

    Google Scholar 

  43. Nalawade SP, Picchioni F, Janssen LPBM (2006) Prog Polym Sci 31:19

    Article  CAS  Google Scholar 

  44. Nauman EB, Ariyapadi MV, Balsara MV, Grocela TA, Furno JS, Liu SH, Mallikarjun R (1988) Chem Eng Commun 66:29

    Article  CAS  Google Scholar 

  45. Baldwin SP, Saltzman WM (1998) Adv Drug Deliv Rev 33:71

    Article  CAS  Google Scholar 

  46. Karageorgiou V, Kaplan D (2005) Biomaterials 26:5474

    Article  CAS  Google Scholar 

  47. Moroni L, de Wijn JR, Blitterswijk CA (2006) Biomaterials 27:974

    Article  CAS  Google Scholar 

  48. Bodmeier R, Wang H, Dixon DJ, Mawson S, Johnston KP (1995) Pharm Res 12:1211

    Article  CAS  Google Scholar 

  49. Elvassore N, Baggio M, Pallado P, Bertucco A (2001) Biotechnol Bioeng 73:449

    Article  CAS  Google Scholar 

  50. Dixon DJ, Johnston KP (1993) J Appl Polym Sci 50:1929

    Article  CAS  Google Scholar 

  51. Gentleman E, Lay AN, Dickerson DA, Nauman EA, Livesay GA, Dee KC (2003) Biomaterials 24:3805

    Article  CAS  Google Scholar 

Download references

Acknowledgements

The financial support of EU Project STRP SurfaceT NMP2-CT-2005-013524 and the Spanish MEC (projects MAT2005-25567-E, MAT-2006-28189-E and MAT2005-25503-E) are greatly acknowledged. A. M. Lopez-Periago and C. A. García-González give acknowledgment to CSIC for its funding support through I3P fellowships.

Author information

Authors and Affiliations

  1. Instituto de Ciencia de Materiales de Barcelona, CSIC, Campus UAB, 08193, Bellaterra, Spain

    Ana M. López-Periago, Carlos A. García-González & Concepcion Domingo

  2. Laboratoire d’Ingénierie des Matériaux et des Hautes Pressions, C.N.R.S., Institut Galilée, Université Paris 13, 99 Avenue Jean Baptiste Clément, 93430, Villetaneuse, France

    Arlette Vega & Pascale Subra

  3. Department of Analytical Chemistry, University of Barcelona, Diagonal 647, 08028, Barcelona, Spain

    Anna Argemí & Javier Saurina

Authors
  1. Ana M. López-Periago
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Arlette Vega
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Pascale Subra
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Anna Argemí
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Javier Saurina
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Carlos A. García-González
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Concepcion Domingo
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ana M. López-Periago.

Rights and permissions

Reprints and permissions

About this article

Cite this article

López-Periago, A.M., Vega, A., Subra, P. et al. Supercritical CO2 processing of polymers for the production of materials with applications in tissue engineering and drug delivery. J Mater Sci 43, 1939–1947 (2008). https://doi.org/10.1007/s10853-008-2461-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10853-008-2461-0

Keywords

Search

Navigation