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Complex formation of cinnamaldehyde-methyl-β-cyclodextrin and muscone-methyl-β-cyclodextrin by supercritical carbon dioxide processing and sealed heating method

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Abstract

Firstly, the interaction between cinnamaldehyde (CIN) and methyl-β- cyclodextrin (MBCD) was studied in aqueous solution. 1:1 inclusion complex was formed and the association constant was 187 ± 9 M−1. Then the complex of CIN–MBCD and muscone–MBCD was prepared both by sealed heating method and by supercritical carbon dioxide (sc CO2) approach. Complete complex was obtained by both methods for CIN–MBCD. Some CIN molecules was weakly associated with MBCD molecules in products by sealed heating method, all CIN molecules was strongly associated with MBCD molecules in products by sc CO2 processing. Complete complex between muscone and MBCD was not obtained. The choice for the size of guest molecule still existed for MBCD cavity in sealed heating method and sc CO2 processing.

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Acknowledgement

This study is supported by Molecular Science Center of Institute of Chemistry, The Chinese Academy of Science.

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  1. Institute of Chemistry, The Chinese Academy of Science, The First North Street 2, Zhongguancun, Beijing, 100190, People’s Republic of China

    Jun He & Wenjing Li

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Correspondence to Jun He.

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He, J., Li, W. Complex formation of cinnamaldehyde-methyl-β-cyclodextrin and muscone-methyl-β-cyclodextrin by supercritical carbon dioxide processing and sealed heating method. J Incl Phenom Macrocycl Chem 63, 61–68 (2009). https://doi.org/10.1007/s10847-008-9489-2

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